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Biology and Biochemistry

D-Index
62
Citations
16865
World Ranking
10641
National Ranking
365

Overview

Jorge Filmus is affiliated with Sunnybrook Health Science Centre in Canada and has contributed to research primarily within the field of Biochemistry, Genetics and Molecular Biology. Their work is notably concentrated in several key subfields including Molecular Biology, Cell Biology, Organic Chemistry, Oncology, and Genetics.

The main research topics addressed by Filmus include:

  • Proteoglycans and glycosaminoglycans research
  • Wnt/β-catenin signaling in development and cancer
  • Glycosylation and Glycoproteins Research
  • Congenital heart defects research
  • Carbohydrate Chemistry and Synthesis
  • Peptidase Inhibition and Analysis
  • Genetic Syndromes and Imprinting

Recent publications authored or co-authored by Jorge Filmus showcase involvement in diverse biological research topics. Notable papers include:

  • "Glypicans, 35 years later" (2023) published in Proteoglycan Research
  • "The function of glypicans in the mammalian embryo" (2022) published in American Journal of Physiology-Cell Physiology

Additional recent papers relevant to Filmus's network of research and co-authors, though not direct authorship, are:

  • "Assembling custom side chains on proteoglycans to interrogate their function in living cells" (2020) in Nature Communications
  • "Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling" (2022) in Developmental Dynamics
  • "Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development" (2024) in Matrix Biology

Frequent co-authors collaborating with Filmus include:

  • Wen Shi
  • Wenshuang Wang
  • Naihan Han
  • Yingying Xu
  • Yunxue Zhao

The scientist's publications have appeared in multiple specialized venues such as Proteoglycan Research, Nature Communications, Matrix Biology, American Journal of Physiology-Cell Physiology, and Developmental Dynamics, indicating a focus on molecular and developmental biology topics related to proteoglycans and signaling pathways.

Best Publications

  • Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

    Gregory E. Hannigan;Chungyee Leung-Hagesteijn;Linda Fitz-Gibbon;Marc G. Coppolino;Marc G. Coppolino

  • Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma

    Mariana Capurro;Ian R Wanless;Morris Sherman;Gerrit J DeBoer

  • Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

    J. Rak;Y. Mitsuhashi;L. Bayko;J. Filmus

  • Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling.

    Mariana I. Capurro;Yun-Yan Xiang;Corrinne Lobe;Jorge Filmus

  • Glypicans: proteoglycans with a surprise.

    Jorge Filmus;Scott B. Selleck

  • CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity

    Rudolf Schmits;Jorge Filmus;Nicole Gerwin;Giorgio Senaldi

  • Inhibition of nuclear hormone receptor activity by calreticulin

    Shoukat Dedhar;Paul S. Rennie;Mary Shago;Chung-Yee Leung Hagesteijn

  • MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF.

    Jorge Filmus;Jorge Filmus;Michael N. Pollak;Michael N. Pollak;Relda Cailleau;Ronald N. Buick;Ronald N. Buick

  • Induction of cyclin D1 overexpression by activated ras.

    J. Filmus;A. I. Robles;Wen Shi;M. J. Wong

  • Glypican-3 Inhibits Hedgehog Signaling during Development by Competing with Patched for Hedgehog Binding

    Mariana I. Capurro;Ping Xu;Wen Shi;Fuchuan Li

  • Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome

    Danielle F. Cano-Gauci;Danielle F. Cano-Gauci;Howard H. Song;Howard H. Song;Huiling Yang;Huiling Yang;Colin McKerlie

  • OVEREXPRESSION OF THE INTEGRIN-LINKED KINASE PROMOTES ANCHORAGE-INDEPENDENT CELL CYCLE PROGRESSION

    Galina Radeva;Teresa Petrocelli;Elke Behrend;Chungyee Leung-Hagesteijn

  • Oncogenes as inducers of tumor angiogenesis

    J. Rak;J. Filmus;J. Filmus;G. Finkenzeller;S. Grugel

  • Oncogenes and Tumor Angiogenesis: Differential Modes of Vascular Endothelial Growth Factor Up-Regulation in ras-transformed Epithelial Cells and Fibroblasts

    Janusz Rak;Yoshihiro Mitsuhashi;Cap Sheehan;Ami Tamir

  • Glypicans in growth control and cancer.

    Jorge Filmus

  • Transforming Growth Factor-α Prevents Detachment-induced Inhibition of c-Src Kinase Activity, Bcl-XLDown-regulation, and Apoptosis of Intestinal Epithelial Cells

    Kirill Rosen;Mariano Loza Coll;Alwin Li;Jorge Filmus

  • Reciprocal paracrine interactions between tumour cells and endothelial cells: the ‘angiogenesis progression’ hypothesis

    J. Rak;J. Filmus;R.S. Kerbel

  • The Loss of Glypican-3 Induces Alterations in Wnt Signaling

    Howard H. Song;Wen Shi;Yun-Yan Xiang;Jorge Filmus

  • Glypican-3 expression is silenced in human breast cancer.

    Yun-Yan Xiang;Yun-Yan Xiang;Virginia Ladeda;Virginia Ladeda;Jorge Filmus;Jorge Filmus

  • Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface.

    Alexandra Traister;Alexandra Traister;Wen Shi;Wen Shi;Jorge Filmus;Jorge Filmus

Frequent Co-Authors

Robert S. Kerbel
Robert S. Kerbel University of Toronto
Michael Pollak
Michael Pollak McGill University
Eiji Miyoshi
Eiji Miyoshi Osaka University
Peter J. Anderson
Peter J. Anderson Monash University
Akira Miyauchi
Akira Miyauchi Tokai University
Linda Z. Penn
Linda Z. Penn University of Toronto
Jean Gariépy
Jean Gariépy University of Toronto
Rafael Roesler
Rafael Roesler Federal University of Rio Grande do Sul
Christopher J. Paige
Christopher J. Paige Princess Margaret Cancer Centre
Pamela S. Ohashi
Pamela S. Ohashi Princess Margaret Cancer Centre

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