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Microbiology

D-Index
61
Citations
19918
World Ranking
2948
National Ranking
83

Overview

Christopher J. Paige is affiliated with the Princess Margaret Cancer Centre in Canada. Their research spans the fields of Immunology and Microbiology as well as Medicine, with a focus on several specific subfields including Immunology, Oncology, Cellular and Molecular Neuroscience, Surgery, and Radiology, Nuclear Medicine and Imaging.

The primary topics explored in their work include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Neuropeptides and Animal Physiology
  • Cancer Immunotherapy and Biomarkers
  • Bladder and Urothelial Cancer Treatments
  • Cardiovascular Conditions and Treatments
  • Cardiomyopathy and Myosin Studies

Christopher J. Paige has contributed to multiple research papers published in reputable venues. Recent publications include:

  • Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells, 2020, Cell Reports
  • Cytotoxic CD4+ T Cells in Bladder Cancer-A New License to Kill, 2020, Cancer Cell
  • Case Report: Persistent Moderate-to-Severe Creatine Kinase Enzyme Activity Elevation in a Subclinical Dog, 2021, Frontiers in Veterinary Science
  • Engineered murine IL-21-secreting leukemia cells induce granzyme B+ T cells and CD4+CD44+CD62L− effector memory cells while suppressing regulatory T cells, leading to long-term survival, 2023, Cancer Immunology Immunotherapy

The researcher collaborates frequently with several coauthors, including Alexandra Berger, Adrián E. Morelli, Tina L. Sumpter, Darling Rojas-Canales, and Mohna Bandyopadhyay.

Their work has had representation across specific publication venues such as:

  • Cell Reports
  • Cancer Cell
  • Frontiers in Veterinary Science
  • Cancer Immunology Immunotherapy

Christopher J. Paige's research contributions focus particularly on the interactions and functions of immune cells, with strong interests in T-cell and B-cell immunology. The investigations also cover roles of neuropeptides in animal physiology and mechanisms relevant to cancer immunotherapy, especially bladder and urothelial cancers. Additionally, interests extend to cardiovascular conditions, treatments, and related molecular studies.

Best Publications

  • Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

    Scott R. McKercher;Bruce E. Torbett;Karen L. Anderson;Gregory W. Henkel

  • TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

    Mark A. Lomaga;Wen Chen Yeh;Ildiko Sarosi;Gordon S. Duncan

  • Profound block in thymocyte development in mice lacking p56lck.

    T. J. Molina;K. Kishihara;D. P. Siderovskid;W. van Ewijk

  • B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals

    Florienne Loder;Bettina Mutschler;Robert J. Ray;Christopher J. Paige

  • Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

    Haruhiko Suzuki;Haruhiko Suzuki;Thomas M. Kündig;Caren Furlonger;Andrew Wakeham;Andrew Wakeham

  • Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4.

    A. Rahemtulla;W. P. Fung-Leung;M. W. Schilham;T. M. Kündig

  • Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors

    Gordon Keller;Christopher Paige;Eli Gilboa;Erwin F. Wagner

  • Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

    Toshifumi Matsuyama;Toshifumi Matsuyama;Tohru Kimura;Tohru Kimura;Tohru Kimura;Motoo Kitagawa;Klaus Pfeffer;Klaus Pfeffer

  • Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

    Kenji Kishihara;Kenji Kishihara;Josef Penninger;Josef Penninger;Valerie A. Wallace;Valerie A. Wallace;Thomas M. Kündig

  • Murine B Cell Leukemia Line with Inducible Surface Immunoglobulin Expression

    Christopher J. Paige;Paul W. Kincade;Peter Ralph

  • CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity

    Rudolf Schmits;Jorge Filmus;Nicole Gerwin;Giorgio Senaldi

  • Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis

    Yu Zhang;Liwei Lu;Caren Furlonger;Gillian E. Wu

  • Bipotential precursors of B cells and macrophages in murine fetal liver.

    Ana Cumano;Christopher J. Paige;Norman N. Iscove;Gerard Brady

  • Cytokine Signaling and Hematopoietic Homeostasis Are Disrupted in Lnk-deficient Mice

    Laura Velazquez;Alec M. Cheng;Heather E. Fleming;Heather E. Fleming;Caren Furlonger

  • Natural Cytotoxic Cells against Solid Tumors in Mice: I. Strain and Age Distribution and Target Cell Susceptibility

    Osias Stutman;Christopher J. Paige;Elizabeth Feo Figarella

  • Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro

    Robert J. Ray;Caren Furlonger;Douglas E. Williams;Christopher J. Paige

  • The many roles of IL-7 in B cell development; mediator of survival, proliferation and differentiation.

    Steven A. Corfe;Steven A. Corfe;Christopher J. Paige;Christopher J. Paige

  • Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity.

    Minna Woo;Minna Woo;Razqallah Hakem;Razqallah Hakem;Caren Furlonger;Caren Furlonger;Anne Hakem;Anne Hakem

  • Immunoglobulin gene rearrangement in immature B cells.

    Richard Maki;John Kearney;Christopher Paige;Susumu Tonegawa

  • Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway.

    Heather E Fleming;Christopher J Paige

Frequent Co-Authors

Jeffrey A. Medin
Jeffrey A. Medin Medical College of Wisconsin
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Ana Cumano
Ana Cumano Institut Pasteur
Andrew Wakeham
Andrew Wakeham Princess Margaret Cancer Centre
Norman N. Iscove
Norman N. Iscove University of Toronto
Pamela S. Ohashi
Pamela S. Ohashi Princess Margaret Cancer Centre
Thomas M. Kündig
Thomas M. Kündig University of Zurich
Juan Carlos Zúñiga-Pflücker
Juan Carlos Zúñiga-Pflücker University of Toronto
Robert Rottapel
Robert Rottapel University of Toronto
Dale A. Ramsden
Dale A. Ramsden University of North Carolina at Chapel Hill

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