Fritz Melchers

Research.com Recognitions

• 1996 - Robert Koch Prize
• 1992 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Microbiology and Immunology
• 1989 - Member of Academia Europaea
• Member of the European Molecular Biology Organization (EMBO)
• Member of the European Molecular Biology Organization (EMBO)

Overview

Best Publications

• Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

  Hajime Karasuyama;Fritz Melchers

  1587
  Citations

• A plaque assay for all cells secreting ig of a given type or class.

  Eva Gronowicz;A. Coutinho;F. Melchers

  1498
  Citations

• Guidelines for the use of flow cytometry and cell sorting in immunological studies

  Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Mübeccel Akdis

  1078
  Citations

• Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

  Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  914
  Citations

• A critical role of λ5 protein in B cell development

  Daisuke Kitamura;Akira Kudo;Stefan Schaal;Werner Müller

  824
  Citations

• The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching

  Antonius Rolink;Fritz Melchers;Jan Andersson

  616
  Citations

• Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

  Unknown

  589
  Citations

• The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

  H Karasuyama;A Kudo;F Melchers

  507
  Citations

• Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement.

  Ulf Grawunder;Thomas M.J. Leu;David G. Schatz;Annick Werner

  500
  Citations

• Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes

  Unknown

  492
  Citations

• The chemokine SDF‐1, stromal cell‐derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4

  Massimo D'Apuzzo;Antonius Rolink;Marcel Loetscher;James A. Hoxie

  490
  Citations

• Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

  Antonius G. Rolink;Stephen L. Nutt;Fritz Melchers;Meinrad Busslinger

  471
  Citations

• Molecular and cellular origins of B lymphocyte diversity.

  Antonius Rolink;Fritz Melchers

  466
  Citations

• Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo.

  A Rolink;A Kudo;H Karasuyama;Y Kikuchi

  445
  Citations

• Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization.

  Wong Yu;Hitoshi Nagaoka;Mila Jankovic;Ziva Misulovin

  436
  Citations

• Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B lymphocyte

  Jan Andersson;Antonio Coutinho;Waldemar Lernhardt;Fritz Melchers

  419
  Citations

• The mitogenic effect of lipopolysaccharide on bone marrow-derived mouse lymphocytes. Lipid A as the mitogenic part of the molecule.

  Jan Andersson;Fritz Melchers;Chris Galanos;Otto Lüderitz

  419
  Citations

• A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes.

  A Kudo;F Melchers

  416
  Citations

• Lambda 5, a new light-chain-related locus selectively expressed in pre-B lymphocytes.

  Nobuo Sakaguchi;Fritz Melchers

  407
  Citations

• Checkpoints in lymphocyte development and autoimmune disease

  Harald von Boehmer;Fritz Melchers

  402
  Citations

• The surrogate light chain in B-cell development

  Fritz Melchers;Hajime Karasuyama;Dirk Haasner;Steven Bauer

  394
  Citations

• CHARACTERIZATION OF IMMATURE B CELLS BY A NOVEL MONOCLONAL ANTIBODY, BY TURNOVER AND BY MITOGEN REACTIVITY

  Antonius G. Rolink;Jan Andersson;Fritz Melchers

  386
  Citations