World's Best Scientists 2026 revealed!
Fritz Melchers

Fritz Melchers

D-Index & Metrics

Immunology

D-Index
100
Citations
34182
World Ranking
729
National Ranking
45

Fritz Melchers publication distribution in Immunology in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Immunology in 2026. The highlighted bar marks where Fritz Melchers sits on this spectrum.

62–71 publications: 9 scientists 72–81 publications: 23 scientists 82–91 publications: 40 scientists 92–101 publications: 72 scientists 102–111 publications: 86 scientists 112–121 publications: 108 scientists 122–131 publications: 150 scientists 132–141 publications: 160 scientists 142–151 publications: 159 scientists 152–161 publications: 189 scientists 162–171 publications: 166 scientists 172–181 publications: 181 scientists 182–191 publications: 188 scientists 192–201 publications: 187 scientists 202–211 publications: 178 scientists 212–221 publications: 158 scientists 222–231 publications: 168 scientists 232–241 publications: 159 scientists 242–251 publications: 160 scientists 252–261 publications: 148 scientists 262–271 publications: 116 scientists 272–281 publications: 125 scientists 282–291 publications: 115 scientists 292–301 publications: 111 scientists 302–311 publications: 95 scientists 312–321 publications: 97 scientists 322–331 publications: 97 scientists 332–341 publications: 99 scientists 342–351 publications: 96 scientists 352–361 publications: 68 scientists 362–371 publications: 76 scientists 372–381 publications: 71 scientists 382–391 publications: 71 scientists 392–401 publications: 62 scientists 402–411 publications: 54 scientists 412–421 publications: 41 scientists 422–431 publications: 63 scientists 432–441 publications: 53 scientists 442–451 publications: 31 scientists 452–461 publications: 42 scientists 462–471 publications: 40 scientists 472–481 publications: 29 scientists 482–491 publications: 34 scientists 492–501 publications: 30 scientists 502–511 publications: 23 scientists 512–521 publications: 41 scientists 522–531 publications: 29 scientists 532–541 publications: 28 scientists 542–551 publications: 16 scientists 552–561 publications: 18 scientists 562–571 publications: 18 scientists 572–581 publications: 17 scientists 582–591 publications: 17 scientists 592–601 publications: 17 scientists 602–611 publications: 19 scientists 612–621 publications: 13 scientists 622–631 publications: 12 scientists 632–641 publications: 11 scientists 642–651 publications: 16 scientists 652–661 publications: 9 scientists 662–671 publications: 5 scientists 672–681 publications: 13 scientists 682–691 publications: 12 scientists 692–701 publications: 6 scientists 702–711 publications: 6 scientists 712–721 publications: 9 scientists 722–731 publications: 9 scientists 732–741 publications: 6 scientists 742–751 publications: 11 scientists 752–761 publications: 10 scientists 762–771 publications: 7 scientists 772–781 publications: 12 scientists 782–791 publications: 7 scientists 792–801 publications: 5 scientists 802–806 publications: 1 scientists 807+ publications: 100 scientists
62 publications 807+

This scientist: 394 publications — 80th percentile

80% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 807 publications or more.

Fritz Melchers D-index placement in Immunology in 2026

The chart shows the D-index (discipline H-index) distribution of Immunology scientists ranked by Research.com in 2026. The highlighted bar marks where Fritz Melchers sits on this spectrum.

40–41 D-Index: 28 scientists 42–43 D-Index: 91 scientists 44–45 D-Index: 157 scientists 46–47 D-Index: 192 scientists 48–49 D-Index: 175 scientists 50–51 D-Index: 188 scientists 52–53 D-Index: 177 scientists 54–55 D-Index: 155 scientists 56–57 D-Index: 194 scientists 58–59 D-Index: 201 scientists 60–61 D-Index: 197 scientists 62–63 D-Index: 201 scientists 64–65 D-Index: 173 scientists 66–67 D-Index: 167 scientists 68–69 D-Index: 172 scientists 70–71 D-Index: 199 scientists 72–73 D-Index: 184 scientists 74–75 D-Index: 133 scientists 76–77 D-Index: 162 scientists 78–79 D-Index: 127 scientists 80–81 D-Index: 121 scientists 82–83 D-Index: 125 scientists 84–85 D-Index: 121 scientists 86–87 D-Index: 102 scientists 88–89 D-Index: 96 scientists 90–91 D-Index: 75 scientists 92–93 D-Index: 72 scientists 94–95 D-Index: 74 scientists 96–97 D-Index: 66 scientists 98–99 D-Index: 68 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 60 scientists 104–105 D-Index: 54 scientists 106–107 D-Index: 36 scientists 108–109 D-Index: 23 scientists 110–111 D-Index: 52 scientists 112–113 D-Index: 41 scientists 114–115 D-Index: 34 scientists 116–117 D-Index: 25 scientists 118–119 D-Index: 28 scientists 120–121 D-Index: 11 scientists 122–123 D-Index: 20 scientists 124–125 D-Index: 27 scientists 126–127 D-Index: 19 scientists 128–129 D-Index: 20 scientists 130–131 D-Index: 16 scientists 132–133 D-Index: 17 scientists 134–135 D-Index: 14 scientists 136–137 D-Index: 15 scientists 138–139 D-Index: 9 scientists 140–141 D-Index: 11 scientists 142–143 D-Index: 9 scientists 144–145 D-Index: 9 scientists 146–147 D-Index: 7 scientists 148–149 D-Index: 7 scientists 150–151 D-Index: 7 scientists 152–153 D-Index: 5 scientists 154–155 D-Index: 8 scientists 156 D-Index: 6 scientists 157+ D-Index: 96 scientists
40 D-Index 157+

This scientist: 100 D-Index — 86th percentile

86% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 157 D-Index or more.

Research.com Recognitions

  • 1996 - Robert Koch Prize
  • 1992 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Microbiology and Immunology
  • 1989 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Fritz Melchers was affiliated with the Leibniz Association in Germany and conducted extensive research in immunology and related biomedical fields. Their body of work spanned several interconnected domains including immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology.

The scientist's research focused primarily on immune cell function and interaction, T-cell and B-cell immunology, and monoclonal and polyclonal antibodies research. Other significant topics explored included immune responses and vaccinations, glycosylation and glycoproteins research, immunodeficiency and autoimmune disorders, and clinical studies related to COVID-19.

Melchers contributed publications to a range of reputable journals. Frequent publication venues included:

  • European Journal of Immunology
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zeitschrift für Rheumatologie
  • Cell Reports

Among their recent papers were:

  • "SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself" (2021, Nature Communications)
  • "Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells" (2020, Cell Reports)
  • "The miR-221/222 cluster regulates hematopoietic stem cell quiescence and multipotency by suppressing both Fos/AP-1/IEG pathway activation and stress-like differentiation to granulocytes" (2023, PLoS Biology)
  • "Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow" (2024, Nature Communications)
  • "In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response" (2020, bioRxiv [Cold Spring Harbor Laboratory])

Collaborations were an important aspect of Melchers' work, with frequent coauthors including:

  • Andreas Radbruch
  • Péter K. Jani
  • Mir-Farzin Mashreghi
  • Pawel Durek
  • Frederik Heinrich

Within scientific communities, Melchers was recognized through awards and memberships such as:

  • Robert Koch Prize (1996)
  • Member of the German National Academy of Sciences Leopoldina with a focus on Microbiology and Immunology (1992)
  • Member of Academia Europaea (1989)
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

    Hajime Karasuyama;Fritz Melchers

  • A plaque assay for all cells secreting ig of a given type or class.

    Eva Gronowicz;A. Coutinho;F. Melchers

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Mübeccel Akdis

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • A critical role of λ5 protein in B cell development

    Daisuke Kitamura;Akira Kudo;Stefan Schaal;Werner Müller

  • The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching

    Antonius Rolink;Fritz Melchers;Jan Andersson

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

    Unknown

  • The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

    H Karasuyama;A Kudo;F Melchers

  • Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement.

    Ulf Grawunder;Thomas M.J. Leu;David G. Schatz;Annick Werner

  • Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes

    Unknown

  • The chemokine SDF‐1, stromal cell‐derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4

    Massimo D'Apuzzo;Antonius Rolink;Marcel Loetscher;James A. Hoxie

  • Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

    Antonius G. Rolink;Stephen L. Nutt;Fritz Melchers;Meinrad Busslinger

  • Molecular and cellular origins of B lymphocyte diversity.

    Antonius Rolink;Fritz Melchers

  • Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo.

    A Rolink;A Kudo;H Karasuyama;Y Kikuchi

  • Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization.

    Wong Yu;Hitoshi Nagaoka;Mila Jankovic;Ziva Misulovin

  • Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B lymphocyte

    Jan Andersson;Antonio Coutinho;Waldemar Lernhardt;Fritz Melchers

  • The mitogenic effect of lipopolysaccharide on bone marrow-derived mouse lymphocytes. Lipid A as the mitogenic part of the molecule.

    Jan Andersson;Fritz Melchers;Chris Galanos;Otto Lüderitz

  • A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes.

    A Kudo;F Melchers

  • Lambda 5, a new light-chain-related locus selectively expressed in pre-B lymphocytes.

    Nobuo Sakaguchi;Fritz Melchers

  • Checkpoints in lymphocyte development and autoimmune disease

    Harald von Boehmer;Fritz Melchers

  • The surrogate light chain in B-cell development

    Fritz Melchers;Hajime Karasuyama;Dirk Haasner;Steven Bauer

  • CHARACTERIZATION OF IMMATURE B CELLS BY A NOVEL MONOCLONAL ANTIBODY, BY TURNOVER AND BY MITOGEN REACTIVITY

    Antonius G. Rolink;Jan Andersson;Fritz Melchers

Frequent Co-Authors

Antonius Rolink
Antonius Rolink University of Basel
Hajime Karasuyama
Hajime Karasuyama Tokyo Medical and Dental University
Jan Andersson
Jan Andersson Uppsala University
Thomas H. Winkler
Thomas H. Winkler University of Erlangen-Nuremberg
Akira Kudo
Akira Kudo Tokyo Institute of Technology
Paolo Ghia
Paolo Ghia Vita-Salute San Raffaele University
Andreas Radbruch
Andreas Radbruch German Rheumatism Research Centre
Walter Messer
Walter Messer Max Planck Society
Maria Leptin
Maria Leptin University of Cologne
Antonio Coutinho
Antonio Coutinho Instituto Gulbenkian de Ciência

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