His primary areas of investigation include Molecular biology, Immunology, Antibody, B cell and Autoantibody. His studies in Molecular biology integrate themes in fields like Gene rearrangement, Gene, Cellular differentiation, Receptor and Bone marrow. His study connects Systemic lupus erythematosus and Immunology.
Thomas H. Winkler does research in Antibody, focusing on Lupus erythematosus specifically. His Lupus erythematosus study incorporates themes from Severe combined immunodeficiency and Antigen. His B cell study integrates concerns from other disciplines, such as Immunoglobulin heavy chain and Anti-SSA/Ro autoantibodies.
His scientific interests lie mostly in Immunology, Antibody, Molecular biology, B cell and Immune system. His research ties Systemic lupus erythematosus and Immunology together. His Antibody research includes themes of Lupus nephritis and Virology.
His studies deal with areas such as Immunoglobulin light chain, Receptor, Gene, B-cell receptor and Bone marrow as well as Molecular biology. The study incorporates disciplines such as Cell culture, Naive B cell and Cell biology in addition to B cell. His study looks at the intersection of Immune system and topics like Inflammation with Cancer research.
Thomas H. Winkler mainly focuses on Immunology, Immune system, Antibody, Severe acute respiratory syndrome coronavirus 2 and Virology. His study on Antigen, Pathogenesis and Memory B cell is often connected to CCR4 as part of broader study in Immunology. His Immune system research includes elements of Inflammation, Cytotoxic T cell and Downregulation and upregulation.
Thomas H. Winkler works in the field of Antibody, focusing on B cell in particular. Thomas H. Winkler combines subjects such as Cell signaling, Receptor, FCGR2B, Allelic exclusion and Immunoglobulin light chain with his study of B cell. In his work, DNA sequencing, Gene, Disease, Mutant and Transgene is strongly intertwined with Monoclonal antibody, which is a subfield of Virology.
His main research concerns Antibody, Phosphorylation, Germinal center, Immune system and Cell biology. B cell and Toxoid are the primary areas of interest in his Antibody study. His primary area of study in B cell is in the field of B-cell receptor.
His Germinal center research is classified as research in Immunology. Thomas H. Winkler works mostly in the field of Immune system, limiting it down to concerns involving Conditional gene knockout and, occasionally, Inflammation. Thomas H. Winkler interconnects Immunoglobulin light chain, Cell culture, Receptor and Allelic exclusion in the investigation of issues within Cell biology.
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The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis.
Kirsten Neubert;Silke Meister;Katrin Moser;Florian Weisel.
Nature Medicine (2008)
The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer
Angela M. Krebs;Julia Mitschke;María Lasierra Losada;Otto Schmalhofer.
Nature Cell Biology (2017)
Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement.
Ulf Grawunder;Thomas M.J. Leu;David G. Schatz;Annick Werner.
Clearance deficiency and systemic lupus erythematosus (SLE).
Udo S. Gaipl;Luis E. Munoz;Gerhard Grossmayer;Kirsten Lauber.
Journal of Autoimmunity (2007)
IL-2 receptor α chain (CD25JAC) expression defines a crucial stage in pre-B cell development
Antonius Rolink;Ulf Grawunder;Thomas H. Winkler;Hajime Karasuyama.
International Immunology (1994)
Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas.
Thomas H. Winkler;Holger Fehr;Joachim R. Kalden.
European Journal of Immunology (1992)
Positive and negative selection events during B lymphopoiesis.
Fritz Melchers;Antonius Rolink;Ulf Grawunder;Thomas H Winkler.
Current Opinion in Immunology (1995)
Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice.
Michael R. Ehrenstein;David R. Katz;Meryl H. Griffiths;Lucienne Papadaki.
Kidney International (1995)
Etiopathogenesis of Systemic Lupus Erythematosus
Martin Herrmann;Thomas Winkler;Udo Gaipl;Hanns-Martin Lorenz.
International Archives of Allergy and Immunology (2000)
Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment.
Antonius G. Rolink;Thomas Winkler;Fritz Melchers;Jan Andersson.
Journal of Experimental Medicine (2000)
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