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Immunology

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76
Citations
28765
World Ranking
1868
National Ranking
127

Medicine

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76
Citations
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World Ranking
18644
National Ranking
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Overview

Falk Hiepe is affiliated with Charité - University Medicine Berlin in Germany and has contributed extensively to medical research, with a primary focus on immunology and rheumatology. Their body of work spans over 100 publications in the broader field of medicine, including 46 focused on immunology and microbiology. Subfields of study that characterize their research include immunology, rheumatology, physiology, molecular biology, and genetics.

The research topics Hiepe has engaged in cover a range of areas centered on immune system function and autoimmune diseases. Key topics include systemic lupus erythematosus research, T-cell and B-cell immunology, immune cell function and interaction, monoclonal and polyclonal antibodies research, systemic sclerosis and related diseases, atherosclerosis and cardiovascular diseases, and chronic lymphocytic leukemia research.

Hiepe's recent publications include the following papers:

  • Targeting CD38 with Daratumumab in Refractory Systemic Lupus Erythematosus (2020) published in New England Journal of Medicine
  • A new molecular classification to drive precision treatment strategies in primary Sjögren's syndrome (2021) published in Nature Communications
  • European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) SLE classification criteria item performance (2021) published in Annals of the Rheumatic Diseases
  • Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells (2020) published in Cell Reports
  • Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities (2020) published in Annals of the Rheumatic Diseases

Frequent co-authors in Hiepe's research include Tobias Alexander, Philipp Enghard, Robert Biesen, Lennard Ostendorf, and Ricard Cervera. Collaborations with these individuals have been recorded across multiple publications, indicating ongoing research partnerships.

Publications have appeared predominantly in the following venues:

  • Annals of the Rheumatic Diseases
  • Scientific Reports
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zeitschrift für Rheumatologie
  • Nature Communications

Falk Hiepe's research contributions focus on autoimmune diseases and immune system regulation, reflected through both the scope of topics and the specialized journals in which the work is published. Their work includes extensive investigations into systemic lupus erythematosus and related autoimmune conditions, positioning them within the interconnected disciplines of immunology and rheumatology.

Best Publications

  • 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus

    Martin Aringer;Karen Costenbader;David Daikh;Ralph Brinks

  • Mycophenolate Mofetil versus Cyclophosphamide for Induction Treatment of Lupus Nephritis

    Gerald B. Appel;Gabriel Contreras;Mary Anne Dooley;Ellen M. Ginzler

  • Competence and competition : the challenge of becoming a long-lived plasma cell

    Andreas Radbruch;Gwendolin Muehlinghaus;Elke O. Luger;Ayako Inamine

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Mübeccel Akdis

  • Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus.

    Marcus Odendahl;Annett Jacobi;Arne Hansen;Eugen Feist

  • MAINTENANCE OF SERUM ANTIBODY LEVELS

    Rudolf A. Manz;Anja E. Hauser;Falk Hiepe;Andreas Radbruch

  • Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response.

    Marcus Odendahl;Henrik Mei;Bimba F. Hoyer;Annett M. Jacobi

  • Short-lived Plasmablasts and Long-lived Plasma Cells Contribute to Chronic Humoral Autoimmunity in NZB/W Mice

    Bimba F. Hoyer;Katrin Moser;Anja E. Hauser;Anette Peddinghaus

  • Type I interferon inhibitor anifrolumab in active systemic lupus erythematosus (TULIP-1): a randomised, controlled, phase 3 trial

    Richard A Furie;Eric F Morand;Ian N Bruce;Susan Manzi

  • Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus.

    William Stohl;Falk Hiepe;Kevin M. Latinis;Mathew Thomas

  • Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95.

    Annett M. Jacobi;Karin Reiter;Meggan Mackay;Cynthia Aranow

  • Long-lived autoreactive plasma cells drive persistent autoimmune inflammation

    Falk Hiepe;Thomas Dörner;Anja E. Hauser;Bimba F. Hoyer

  • Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system.

    Tobias Alexander;Andreas Thiel;Oliver Rosen;Gero Massenkeil

  • Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjögren's syndrome.

    D I Stott;F Hiepe;M Hummel;G Steinhauser

  • The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus

    Tobias Alexander;Ramona Sarfert;Jens Klotsche;Anja A. Kühl

  • Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients

    Katharina Hanke;Claudia S Brückner;Cornelia Dähnrich;Dörte Huscher

  • γ-secretase directly sheds the survival receptor BCMA from plasma cells

    Sarah A. Laurent;Franziska S. Hoffmann;Peer-Hendrik Kuhn;Qingyu Cheng

  • Memory B and memory plasma cells.

    Taketoshi Yoshida;Henrik Mei;Thomas Dörner;Falk Hiepe

  • Phase I/II trial of autologous stem cell transplantation in systemic sclerosis: procedure related mortality and impact on skin disease.

    M Binks;J. R. Passweg;D. Furst;P. Mcsweeney

  • Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus

    Caroline von Spee-Mayer;Elise Siegert;Dimas Abdirama;Angelika Rose

Frequent Co-Authors

Andreas Radbruch
Andreas Radbruch German Rheumatism Research Centre
Thomas Dörner
Thomas Dörner Charité - University Medicine Berlin
Gerd R. Burmester
Gerd R. Burmester Charité - University Medicine Berlin
Gabriela Riemekasten
Gabriela Riemekasten University of Lübeck
Rudolf A. Manz
Rudolf A. Manz University of Lübeck
Frank Buttgereit
Frank Buttgereit Charité - University Medicine Berlin
Andreas Meisel
Andreas Meisel Charité - University Medicine Berlin
Martin Aringer
Martin Aringer TU Dresden
Andreas Grützkau
Andreas Grützkau German Rheumatism Research Centre
Claudia Berek
Claudia Berek Leibniz Association

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