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Immunology

D-Index
78
Citations
25876
World Ranking
1734
National Ranking
119

Overview

Andreas Mackensen is affiliated with the University of Erlangen-Nuremberg in Germany and specializes in medicine with a strong focus on immunology and microbiology. Their research primarily addresses immunology, oncology, molecular biology, genetics, and hematology. The work notably revolves around CAR-T cell therapy research, immune cell function and interaction, and T-cell and B-cell immunology, alongside studies in viral infectious diseases and gene expression in insects, biosimilars and bioanalytical methods, cancer immunotherapy and biomarkers, and hematopoietic stem cell transplantation.

The scientist has contributed to a variety of publications across multiple esteemed venues. Their frequent publication outlets include Blood, Annals of the Rheumatic Diseases, Cancers, Journal for ImmunoTherapy of Cancer, and The Lancet.

Recent notable papers authored or co-authored by Andreas Mackensen are:

  • Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus (2022, Nature Medicine)
  • CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up (2024, New England Journal of Medicine)
  • CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus (2021, New England Journal of Medicine)
  • CAR-HEMATOTOX: a model for CAR T-cell-related hematologic toxicity in relapsed/refractory large B-cell lymphoma (2021, Blood)
  • CAR T-cell therapy in autoimmune diseases (2023, The Lancet)

Their collaborative network includes frequent co-authors such as Simon Völkl, Fabian Müller, Michael Aigner, Dimitrios Mougiakakos, and Georg Schett.

Andreas Mackensen's research domains intersect immunological cell therapies and hematology with a particular interest in CAR-T cell therapy applications in both oncology and autoimmune diseases. Their work contributes to understanding the mechanisms behind immune cell function and interaction as well as providing insights into the clinical implications of CAR-T therapies.

Best Publications

  • Inhibitory effect of tumor cell–derived lactic acid on human T cells

    Karin Fischer;Petra Hoffmann;Simon Voelkl;Norbert Meidenbauer

  • LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.

    Almut Brand;Katrin Singer;Gudrun E. Koehl;Marlene Kolitzus

  • Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy.

    Christian Blank;Thomas F. Gajewski;Andreas Mackensen

  • CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up

    Unknown

  • Tumor-derived lactic acid modulates dendritic cell activation and antigen expression

    Eva Gottfried;Leoni A. Kunz-Schughart;Leoni A. Kunz-Schughart;Stephanie Ebner;Stephanie Ebner;Wolfgang Mueller-Klieser;Wolfgang Mueller-Klieser

  • Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion.

    Christian Blank;Andreas Mackensen

  • CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus

    Dimitrios Mougiakakos;Gerhard Krönke;Simon Völkl;Sascha Kretschmann

  • Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells.

    Andreas Mackensen;Birgit Herbst;Ji-Li Chen;Gabriele Köhler

  • Effector Function of Human Tumor-Specific CD8 T Cells in Melanoma Lesions: A State of Local Functional Tolerance

    Alfred Zippelius;Pascal Batard;Verena Rubio-Godoy;Gilles Bioley

  • Bispecific T-Cell Engager (BiTE) Antibody Construct Blinatumomab for the Treatment of Patients With Relapsed/Refractory Non-Hodgkin Lymphoma: Final Results From a Phase I Study

    Maria-Elisabeth Goebeler;Stefan Knop;Andreas Viardot;Peter Kufer

  • Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro.

    Christian Blank;Juergen Kuball;Simon Voelkl;Heinz Wiendl

  • Phase I Study of Adoptive T-Cell Therapy Using Antigen-Specific CD8+ T Cells for the Treatment of Patients With Metastatic Melanoma

    Andreas Mackensen;Norbert Meidenbauer;Sandra Vogl;Monika Laumer

  • Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig–coated artificial antigen-presenting cells

    Mathias Oelke;Marcela V. Maus;Dominic Didiano;Carl H. June

  • CAR-HEMATOTOX: A model for CAR T-cell related hematological toxicity in relapsed/refractory large B-cell lymphoma.

    Kai Rejeski;Ariel Perez Perez;Pierre Sesques;Eva Hoster

  • Isolation and characterization of human antigen-specific TCRαβ+ CD4-CD8- double-negative regulatory T cells

    Karin Fischer;Simon Voelkl;Jana Heymann;Grzegorz K. Przybylski

  • Presence of IgE antibodies to bovine serum albumin in a patient developing anaphylaxis after vaccination with human peptide-pulsed dendritic cells.

    Andreas Mackensen;Ruth Dräger;Michael Schlesier;Roland Mertelsmann

  • Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

    Nimitha R Mathew;Nimitha R Mathew;Francis Baumgartner;Lukas Braun;David O'Sullivan

  • CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs.

    Regina Jitschin;Martina Braun;Maike Büttner;Katja Dettmer-Wilde

  • Pembrolizumab plus lenalidomide and dexamethasone for patients with treatment-naive multiple myeloma (KEYNOTE-185): a randomised, open-label, phase 3 trial

    Saad Zafar Usmani;Fredrik Schjesvold;Albert Oriol;Lionel Karlin

  • Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cells

    Karin Fischer;Simon Voelkl;Jana Berger;Reinhard Andreesen

  • Direct evidence to support the immunosurveillance concept in a human regressive melanoma.

    A Mackensen;G Carcelain;S Viel;M C Raynal

  • Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia.

    Regina Jitschin;Andreas D Hofmann;Heiko Bruns;Andreas Giessl

Frequent Co-Authors

Reinhard Andreesen
Reinhard Andreesen University of Regensburg
Marina Kreutz
Marina Kreutz University of Regensburg
Gabriele Köhler
Gabriele Köhler University of Münster
Axel Hauschild
Axel Hauschild Kiel University
Dirk Schadendorf
Dirk Schadendorf University of Duisburg-Essen
Michael Rehli
Michael Rehli University of Regensburg
Richard D. Pancost
Richard D. Pancost University of Bristol
Gerold Schuler
Gerold Schuler University of Erlangen-Nuremberg
Claus Garbe
Claus Garbe University of Tübingen
Gavin L. Foster
Gavin L. Foster University of Southampton

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