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Immunology

D-Index
52
Citations
12799
World Ranking
4036
National Ranking
159

Overview

Marij J. P. Welters is affiliated with the Leiden University Medical Center in the Netherlands. Their research predominantly spans the fields of medicine and immunology and microbiology, with a particular focus on oncology and immunology. Their work engages with various subfields including epidemiology, molecular biology, and obstetrics and gynecology.

The core topics of Welters' research include cancer immunotherapy and biomarkers, immunotherapy and immune responses, CAR-T cell therapy research, cervical cancer and HPV research, immune cell function and interaction, endometrial and cervical cancer treatments, as well as single-cell and spatial transcriptomics.

Frequent publication venues for their research include:

  • Journal for ImmunoTherapy of Cancer
  • Nature Communications
  • Cancer Immunology Research
  • Cancers
  • Cancer Immunology Immunotherapy

Welters has collaborated extensively with several coauthors such as Sjoerd H. van der Burg, Saskia J. Santegoets, Mariëtte I.E. van Poelgeest, Judith R. Kroep, and Els M.E. Verdegaal.

Among their recent publications are the following papers:

  • Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial, 2020, Nature Communications
  • CD39 Identifies the CD4+ Tumor-Specific T-cell Population in Human Cancer, 2020, Cancer Immunology Research
  • Strong vaccine responses during chemotherapy are associated with prolonged cancer survival, 2020, Science Translational Medicine
  • Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment, 2023, Nature Communications
  • CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors, 2024, Cellular and Molecular Immunology

Best Publications

  • Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

    Gemma G Kenter;Marij J P Welters;A Rob P M Valentijn;Margriet J G Lowik

  • Actively personalized vaccination trial for newly diagnosed glioblastoma

    Norbert Hilf;Sabrina Kuttruff-Coqui;Katrin Frenzel;Valesca Bukur

  • Induction of tumor-specific CD4+ and CD8+ T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine.

    Marij J P Welters;Gemma G Kenter;Sytse J Piersma;Annelies P G Vloon

  • Phase I immunotherapeutic trial with long peptides spanning the E6 and E7 sequences of high-risk human papillomavirus 16 in end-stage cervical cancer patients shows low toxicity and robust immunogenicity

    Gemma G Kenter;Marij J P Welters;A Rob P M Valentijn;Margriet J G Lowik

  • Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.

    Pia Kvistborg;Daisy Philips;Sander Kelderman;Lois Hageman

  • Chemotherapy alters monocyte differentiation to favor generation of cancer-supporting M2 macrophages in the tumor microenvironment

    Eveline M. Dijkgraaf;Moniek Heusinkveld;Bart Tummers;Lisa T.C. Vogelpoel

  • M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells.

    Moniek Heusinkveld;Peggy J. de Vos van Steenwijk;Renske Goedemans;Tamara H. Ramwadhdoebe

  • Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses

    Marij J. P. Welters;Gemma G. Kenter;Peggy J. de Vos van Steenwijk;Margriet J. G. Löwik

  • NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines.

    Nadine van Montfoort;Linda Borst;Michael J. Korrer;Marjolein Sluijter

  • Frequent display of human papillomavirus type 16 E6-specific memory t-Helper cells in the healthy population as witness of previous viral encounter.

    Marij J. P. Welters;Annemieke de Jong;Susan J. F. van den Eeden;Jeanette M. van der Hulst

  • Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens

    Sjoerd H. van der Burg;Sytse J. Piersma;Annemieke de Jong;Jeanette M. van der Hulst

  • Response definition criteria for ELISPOT assays revisited.

    Z. Moodie;L. Price;C. Gouttefangeas;A Mander

  • Induction of p53-specific immunity by a p53 synthetic long peptide vaccine in patients treated for metastatic colorectal cancer.

    Frank M. Speetjens;Peter J.K. Kuppen;Marij J.P. Welters;Farah Essahsah

  • HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial

    Mariette I E van Poelgeest;Marij J P Welters;Edith M G van Esch;Linda F M Stynenbosch

  • Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study

    Susanna Mandruzzato;Sven Brandau;Cedrik M. Britten;Cedrik M. Britten;Vincenzo Bronte

  • Vaccination during myeloid cell depletion by cancer chemotherapy fosters robust T cell responses.

    Marij J. Welters;Tetje C. van der Sluis;Hélène van Meir;Nikki M. Loof

  • Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry.

    Saskia J. A. M. Santegoets;Eveline M. Dijkgraaf;Alessandra Battaglia;Philipp Beckhove

  • A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer

    E. M. Dijkgraaf;S. J. A. M. Santegoets;An Reyners;R. Goedemans

  • Defining the critical hurdles in cancer immunotherapy

    Bernard A. Fox;Bernard A. Fox;Dolores J. Schendel;Lisa H. Butterfield;Steinar Aamdal

  • Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response

    Mariëtte I E van Poelgeest;Marij J P Welters;Renee Vermeij;Linda F M Stynenbosch

  • The CIMT-monitoring panel: a two-step approach to harmonize the enumeration of antigen-specific CD8+ T lymphocytes by structural and functional assays.

    C. M. Britten;C. Gouttefangeas;M. J. P. Welters;G. Pawelec

Frequent Co-Authors

Sjoerd H. van der Burg
Sjoerd H. van der Burg Leiden University Medical Center
Cornelis J. M. Melief
Cornelis J. M. Melief ISA Pharmaceuticals (Netherlands)
Gemma G. Kenter
Gemma G. Kenter Vrije Universiteit Amsterdam
Gert Jan Fleuren
Gert Jan Fleuren Leiden University Medical Center
Christian H. Ottensmeier
Christian H. Ottensmeier University of Southampton
Rienk Offringa
Rienk Offringa German Cancer Research Center
Jan W. Drijfhout
Jan W. Drijfhout Leiden University Medical Center
Ekaterina S. Jordanova
Ekaterina S. Jordanova Vrije Universiteit Amsterdam
Kees L. M. C. Franken
Kees L. M. C. Franken Leiden University Medical Center
Per thor Straten
Per thor Straten University of Copenhagen

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