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Christian H. Ottensmeier

Christian H. Ottensmeier

D-Index & Metrics

Immunology

D-Index
78
Citations
38681
World Ranking
1714
National Ranking
150

Overview

Christian H. Ottensmeier is affiliated with the University of Southampton in the United Kingdom. Their research spans primarily the fields of Medicine and Immunology and Microbiology, with significant contributions across Oncology, Immunology, Pulmonary and Respiratory Medicine, Molecular Biology, and Infectious Diseases.

The main topics of Christian H. Ottensmeier's work include:

  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Lung Cancer Treatments and Mutations
  • Vaccines and immunoinformatics approaches
  • COVID-19 Clinical Research Studies

Recent publications reflect a focus on immune responses in cancer and infectious diseases. Select papers include:

  • "Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19" (2020), published in Cell
  • "NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors" (2020), Cancer Research
  • "Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2-reactive CD8 + T cells" (2021), Science Immunology
  • "Nivolumab versus placebo in patients with relapsed malignant mesothelioma (CONFIRM): a multicentre, double-blind, randomised, phase 3 trial" (2021), The Lancet Oncology
  • "M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer" (2020), Journal for ImmunoTherapy of Cancer

Christian H. Ottensmeier frequently collaborates with several researchers in their field, including:

  • Gareth J. Thomas
  • Pandurangan Vijayanand
  • Serena Chee
  • Adrian von Witzleben
  • Simon Laban

Publication venues where Christian H. Ottensmeier's work appears regularly include:

  • Journal of Clinical Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Regular and Young Investigator Award Abstracts
  • Laryngo-Rhino-Otologie

Best Publications

  • Improved Survival with Ipilimumab in Patients with Metastatic Melanoma.

    F. Stephen Hodi;Steven J. O'Day;David F. McDermott;Robert W. Weber

  • Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

    Nicholas McGranahan;Rachel Rosenthal;Crispin T. Hiley;Crispin T. Hiley;Andrew J. Rowan

  • Cancer classification using the Immunoscore: a worldwide task force

    Jérôme Galon;Franck Pagès;Francesco M Marincola;Francesco M Marincola;Helen K Angell;Helen K Angell

  • Actively personalized vaccination trial for newly diagnosed glioblastoma

    Norbert Hilf;Sabrina Kuttruff-Coqui;Katrin Frenzel;Valesca Bukur

  • Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

    Frederick Arce Vargas;Andrew J S Furness;Kevin Litchfield;Kroopa Joshi

  • Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer

    Anusha-Preethi Ganesan;James Clarke;James Clarke;Oliver Wood;Eva M Garrido-Martin

  • Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4 + T Cells in COVID-19.

    Benjamin J. Meckiff;Ciro Ramírez-Suástegui;Vicente Fajardo;Serena J. Chee

  • DNA vaccines: precision tools for activating effective immunity against cancer.

    Jason Rice;Christian H. Ottensmeier;Freda K. Stevenson

  • Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.

    Frederick Arce Vargas;Andrew J.S. Furness;Andrew J.S. Furness;Isabelle Solomon;Kroopa Joshi;Kroopa Joshi

  • Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer

    M J Ward;S M Thirdborough;T Mellows;C Riley

  • Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.

    Pia Kvistborg;Daisy Philips;Sander Kelderman;Lois Hageman

  • NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

    Kirsty Ford;Christopher J Hanley;Massimiliano Mellone;Cedric Szyndralewiez

  • Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma

    Delin Zhu;Helen McCarthy;Christian H. Ottensmeier;Peter Johnson

  • Binding of Ovarian Cancer Cells to Peritoneal Mesothelium in Vitro Is Partly Mediated by CD44H

    Stephen A. Cannistra;Geoffrey S. Kansas;Jonathan Niloff;Brenda DeFranzo

  • Geospatial immune variability illuminates differential evolution of lung adenocarcinoma

    Khalid AbdulJabbar;Shan E. Ahmed Raza;Rachel Rosenthal;Rachel Rosenthal;Mariam Jamal-Hanjani;Mariam Jamal-Hanjani

  • A Phase I/II, Multiple-Dose, Dose-Escalation Study of Siltuximab, an Anti-Interleukin-6 Monoclonal Antibody, in Patients with Advanced Solid Tumors

    Eric E. Angevin;Josep Tabernero;Elena E. Elez;Steven Cohen

  • Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8 + T cells.

    Anthony Kusnadi;Ciro Ramírez-Suástegui;Vicente Fajardo;Serena J Chee

  • Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer.

    James Clarke;James Clarke;Bharat Panwar;Ariel Madrigal;Divya Singh

  • Response definition criteria for ELISPOT assays revisited.

    Z. Moodie;L. Price;C. Gouttefangeas;A Mander

  • Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression.

    Christian H. Ottensmeier;Andrew R. Thompsett;Delin Zhu;Bridget S. Wilkins

  • Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study

    Susanna Mandruzzato;Sven Brandau;Cedrik M. Britten;Cedrik M. Britten;Vincenzo Bronte

  • DNA vaccination with electroporation induces increased antibody responses in patients with prostate cancer.

    Lindsey Low;Ann Mander;Katy McCann;David Dearnaley

Frequent Co-Authors

Pandurangan Vijayanand
Pandurangan Vijayanand La Jolla Institute For Allergy & Immunology
Freda K. Stevenson
Freda K. Stevenson University of Southampton
Paul Lorigan
Paul Lorigan University of Manchester
Sjoerd H. van der Burg
Sjoerd H. van der Burg Leiden University Medical Center
Marij J. P. Welters
Marij J. P. Welters Leiden University Medical Center
Grégory Seumois
Grégory Seumois La Jolla Institute For Allergy & Immunology
Ugur Sahin
Ugur Sahin Johannes Gutenberg University of Mainz
Hans-Georg Rammensee
Hans-Georg Rammensee University of Tübingen
Peter Johnson
Peter Johnson University of Southampton
Ferhat Ay
Ferhat Ay La Jolla Institute For Allergy & Immunology

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