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Immunology

D-Index
83
Citations
25286
World Ranking
1441
National Ranking
122

Medicine

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83
Citations
25311
World Ranking
15609
National Ranking
1439

Overview

Freda K. Stevenson is affiliated with the University of Southampton in the United Kingdom. Their research primarily focuses on medicine, with particular expertise in immunology and microbiology. Their scholarly work spans various subfields including genetics, immunology, pathology and forensic medicine, radiology, nuclear medicine and imaging, and molecular biology.

The researcher has contributed extensively to topics related to chronic lymphocytic leukemia, lymphoma diagnosis and treatment, monoclonal and polyclonal antibodies, immunodeficiency and autoimmune disorders, glycosylation and glycoproteins, immune cell function and interaction, as well as signaling pathways such as PI3K/AKT/mTOR in cancer.

Frequent co-authors who have collaborated on publications include:

  • Francesco Forconi
  • Graham Packham
  • Dean Bryant
  • Andrew J. Steele
  • Giorgia Chiodin

They have published predominantly in the journal Blood, with eleven publications, followed by contributions to HemaSphere, Cellular Signalling, Cellular and Molecular Life Sciences, and Scientific Reports.

Selected recent papers authored or co-authored by Freda K. Stevenson include:

  • Exploring the pathways to chronic lymphocytic leukemia, 2021, Blood
  • IGHV sequencing reveals acquired N-glycosylation sites as a clonal and stable event during follicular lymphoma evolution, 2020, Blood
  • Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells, 2021, Cellular and Molecular Life Sciences
  • Insertion of atypical glycans into the tumor antigen-binding site identifies DLBCLs with distinct origin and behavior, 2021, Blood
  • Celebrating 20 Years of IGHV Mutation Analysis in CLL, 2020, HemaSphere

Best Publications

  • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

    Terry J. Hamblin;Zadie Davis;Zadie Davis;Anne Gardiner;Anne Gardiner;David G. Oscier;David G. Oscier

  • CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease.

    Terry J. Hamblin;Jenny A. Orchard;Rachel E. Ibbotson;Zadie Davis

  • Chronic lymphocytic leukaemia.

    Thomas J. Kipps;Freda K. Stevenson;Catherine J. Wu;Carlo M. Croce

  • Chronic lymphocytic leukemia : revelations from the B-cell receptor

    Freda K. Stevenson;Federico Caligaris-Cappio

  • DNA vaccines: precision tools for activating effective immunity against cancer.

    Jason Rice;Christian H. Ottensmeier;Freda K. Stevenson

  • B-cell receptor signaling in chronic lymphocytic leukemia

    Freda K. Stevenson;Sergey Krysov;Andrew J. Davies;Andrew J. Steele

  • DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma

    Catherine A. King;Myfanwy B. Spellerberg;Delin Zhu;Jason Rice

  • Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia.

    Stuart Lanham;Terry Hamblin;David Oscier;Rachel Ibbotson

  • Differential Rates of Somatic Hypermutation in VH Genes Among Subsets of Chronic Lymphocytic Leukemia Defined by Chromosomal Abnormalities

    David G. Oscier;Andrew Thompsett;Andrew Thompsett;Delin Zhu;Delin Zhu;Freda K. Stevenson;Freda K. Stevenson

  • Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma

    Delin Zhu;Helen McCarthy;Christian H. Ottensmeier;Peter Johnson

  • Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status.

    C. Ian Mockridge;Kathleen N. Potter;Isla Wheatley;Louise A. Neville

  • ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia.

    Paolo Ghia;K. Stamatopoulos;C. Belessi;C. Moreno

  • VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities.

    V Pascual;K Victor;M Spellerberg;T J Hamblin

  • Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype.

    V Pascual;K Victor;D Lelsz;M B Spellerberg

  • Immunoglobulin V genes and CD38 expression in CLL

    T. J. Hamblin;J. A. Orchard;A. Gardiner;D. G. Oscier

  • Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression.

    Christian H. Ottensmeier;Andrew R. Thompsett;Delin Zhu;Bridget S. Wilkins

  • Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia

    Graham Packham;Freda K. Stevenson

  • Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins

    Vania Coelho;Sergey Krysov;Amir M. Ghaemmaghami;Mohamed Emara

  • DNA vaccination with electroporation induces increased antibody responses in patients with prostate cancer.

    Lindsey Low;Ann Mander;Katy McCann;David Dearnaley

  • Idiotypic vaccination against human B-cell lymphoma. Rescue of variable region gene sequences from biopsy material for assembly as single-chain Fv personal vaccines.

    Robert E. Hawkins;Delin Zhu;Milan Ovecka;Greg Winter

  • Correction: Chronic lymphocytic leukaemia

    Thomas J. Kipps;Freda K. Stevenson;Catherine J. Wu;Carlo M. Croce

Frequent Co-Authors

Graham Packham
Graham Packham University of Southampton
Christian H. Ottensmeier
Christian H. Ottensmeier University of Southampton
Peter Johnson
Peter Johnson University of Southampton
Martin J. Glennie
Martin J. Glennie University of Southampton
Andrew J. T. George
Andrew J. T. George Imperial College London
David Oscier
David Oscier Royal Bournemouth Hospital
Mark S. Cragg
Mark S. Cragg University of Southampton
Robert E. Hawkins
Robert E. Hawkins University of Manchester
Jacob B. Natvig
Jacob B. Natvig University of Oslo
Stephen T. Holgate
Stephen T. Holgate University of Southampton

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