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Overview

David Oscier is affiliated with the Royal Bournemouth Hospital in the United Kingdom and focuses primarily on medical research. Their work spans several interconnected fields, with a concentration on genetics, pathology and forensic medicine, immunology, oncology, and pulmonary and respiratory medicine.

The main topics covered in their research include chronic lymphocytic leukemia research, lymphoma diagnosis and treatment, immunodeficiency and autoimmune disorders, advanced breast cancer therapies, genomic variations and chromosomal abnormalities, cancer genomics and diagnostics, and monoclonal and polyclonal antibodies research.

Throughout their career, David Oscier has contributed to a significant number of publications, frequently appearing in well-regarded venues such as Blood, Leukemia, HemaSphere, Haematologica, and Cancers. The following are some recent papers authored or co-authored by them:

  • Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL, 2020, Blood
  • Genetic and phenotypic attributes of splenic marginal zone lymphoma, 2021, Blood
  • Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center study, 2020, Haematologica
  • Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial, 2020, Leukemia
  • Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY, 2022, Leukemia

Collaboration has been an important aspect of their work, with frequent co-authors including:

  • Zadie Davis
  • Κώστας Σταματόπουλος
  • Paolo Ghia
  • Jonathan C. Strefford
  • Lydia Scarfò

David Oscier's research contributes to better understanding of hematological malignancies, particularly chronic lymphocytic leukemia and related lymphomas. Their focus on genetic and phenotypic attributes aids in refining disease classification and prognosis.

Best Publications

  • International Scoring System for Evaluating Prognosis in Myelodysplastic Syndromes

    Peter Greenberg;Christopher Cox;Michelle M. LeBeau;Pierre Fenaux

  • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

    Terry J. Hamblin;Zadie Davis;Zadie Davis;Anne Gardiner;Anne Gardiner;David G. Oscier;David G. Oscier

  • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

    Thomas Ernst;Andrew J Chase;Andrew J Chase;Joannah Score;Joannah Score;Claire E Hidalgo-Curtis;Claire E Hidalgo-Curtis

  • Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders

    Amy V. Jones;Sebastian Kreil;Katerina Zoi;Katherine Waghorn

  • ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile

    Adrian Wiestner;Andreas Rosenwald;Todd S. Barry;George Wright

  • CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease.

    Terry J. Hamblin;Jenny A. Orchard;Rachel E. Ibbotson;Zadie Davis

  • Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial

    D Catovsky;S Richards;E Matutes;D Oscier

  • Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities.

    Gunnar Juliusson;David G. Oscier;Margaret Fitchett;Fiona M. Ross

  • ZAP-70 expression and prognosis in chronic lymphocytic leukaemia

    Jenny A Orchard;Rachel E Ibbotson;Zadie Davis;Adrian Wiestner

  • Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

    Giulia Fabbri;Silvia Rasi;Davide Rossi;Vladimir A. Trifonov

  • Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors.

    David G. Oscier;Anne C. Gardiner;Sarah J. Mould;Sharron Glide

  • Myelodysplastic syndromes: a scoring system with prognostic significance

    G. J. Mufti;J. R. Stevens;D. G. Oscier;T. J. Hamblin

  • Eradication of Minimal Residual Disease in B-Cell Chronic Lymphocytic Leukemia After Alemtuzumab Therapy Is Associated With Prolonged Survival

    Paul Moreton;Ben Kennedy;Guy Lucas;Michael Leach

  • Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies

    Andreas Agathangelidis;Nikos Darzentas;Anastasia Hadzidimitriou;Xavier Brochet

  • JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms.

    Amy V Jones;Andrew Chase;Richard T Silver;David Oscier

  • Guidelines for the diagnosis, investigation and management of polycythaemia/erythrocytosis

    Mary F. McMullin;D. Bareford;P. Campbell;A. R. Green

  • Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms.

    Francis H. Grand;Claire E. Hidalgo-Curtis;Thomas Ernst;Katerina Zoi

  • Guidelines for the diagnosis and therapy of adult myelodysplastic syndromes.

    David Bowen;Dominic Culligan;Simon Jowitt;Stephen Kelsey

  • The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo

    Victoria J. Weston;Ceri E. Oldreive;Anna Skowronska;David G. Oscier

  • Inactivating mutations of the histone methyltransferase EZH2 in myeloid disorders

    T Ernst;A Chase;J Score;C Hidalgo-Curtis

Frequent Co-Authors

Richard Rosenquist
Richard Rosenquist Karolinska Institute
Paolo Ghia
Paolo Ghia Vita-Salute San Raffaele University
Kostas Stamatopoulos
Kostas Stamatopoulos Centre for Research and Technology Hellas
Šárka Pospíšilová
Šárka Pospíšilová Masaryk University
Daniel Catovsky
Daniel Catovsky Institute of Cancer Research
Frederic Davi
Frederic Davi Assistance Publique – Hôpitaux de Paris
Martin J. S. Dyer
Martin J. S. Dyer University of Leicester
Gunnar Juliusson
Gunnar Juliusson Lund University
Estella Matutes
Estella Matutes University of Barcelona
Nicholas Chiorazzi
Nicholas Chiorazzi Feinstein Institute for Medical Research

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