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Biology and Biochemistry

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Medicine

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80
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17315
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Overview

Graham Packham is affiliated with the University of Southampton in the United Kingdom. Their research primarily spans the fields of medicine and biochemistry, genetics, and molecular biology, with significant contributions to subfields such as molecular biology, genetics, ocean engineering, pathology and forensic medicine, and immunology.

The scientist's work concentrates on topics including chronic lymphocytic leukemia research, lymphoma diagnosis and treatment, protein degradation and inhibitors, drilling and well engineering, oil and gas production techniques, hydraulic fracturing and reservoir analysis, and cancer-related gene regulation.

Notable recent papers authored by Graham Packham include:

  • BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression (2020), published in Blood Advances
  • KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas (2021), published in Blood
  • Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment (2022), published in Blood
  • Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells (2021), published in Cellular and Molecular Life Sciences
  • Insertion of atypical glycans into the tumor antigen-binding site identifies DLBCLs with distinct origin and behavior (2021), published in Blood

Frequent collaborators include:

  • Francesco Forconi
  • Beatriz Valle-Argos
  • Freda K. Stevenson
  • Andrew J. Steele
  • Dean Bryant

The scientist has published extensively in several academic venues, notably:

  • Blood
  • Exploration of Targeted Anti-tumor Therapy
  • Cellular Signalling
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)

Best Publications

  • The ornithine decarboxylase gene is a transcriptional target of c-Myc.

    Concha Bello-Fernandez;Graham Packham;John L. Cleveland

  • Chronic lymphocytic leukaemia.

    Thomas J. Kipps;Freda K. Stevenson;Catherine J. Wu;Carlo M. Croce

  • High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers.

    Steffen Fredersdorf;Jorges Burns;Alistair M. Milne;Graham Packham

  • B-cell receptor signaling in chronic lymphocytic leukemia

    Freda K. Stevenson;Sergey Krysov;Andrew J. Davies;Andrew J. Steele

  • Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia.

    Stuart Lanham;Terry Hamblin;David Oscier;Rachel Ibbotson

  • Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma.

    Thomas Armstrong;Graham Packham;Lindsay B. Murphy;Adrian C. Bateman

  • c-Myc and apoptosis.

    Graham Packham;John L. Cleveland;John L. Cleveland

  • Ornithine decarboxylase is a mediator of c-Myc-induced apoptosis.

    G Packham;J L Cleveland

  • Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status.

    C. Ian Mockridge;Kathleen N. Potter;Isla Wheatley;Louise A. Neville

  • Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia.

    L S Young;R Lau;M Rowe;G Niedobitek

  • Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia

    Graham Packham;Freda K. Stevenson

  • E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis.

    S W Hiebert;G Packham;D K Strom;R Haffner

  • Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation.

    Graham Packham;Graham Packham;Matthew Brimmell;L. John Cleveland;L. John Cleveland

  • Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins

    Vania Coelho;Sergey Krysov;Amir M. Ghaemmaghami;Mohamed Emara

  • BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability.

    Matthew Brimmell;Rezzeline Mendiola;Jonathan Mangion;Graham Packham;Graham Packham

  • Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

    Jessica Okosun;Rachel L Wolfson;Jun Wang;Shamzah Araf

  • Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1

    Christine M Eischen;Graham Packham;John Nip;Brian E Fee

  • Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling.

    Claire A. Walshe;Stephen A. Beers;Ruth R. French;Claude H.T. Chan

  • BAG-1: a multifunctional regulator of cell growth and survival

    Paul A Townsend;Ramsey I Cutress;Adam Sharp;Matthew Brimmell

  • Correction: Chronic lymphocytic leukaemia

    Thomas J. Kipps;Freda K. Stevenson;Catherine J. Wu;Carlo M. Croce

Frequent Co-Authors

Freda K. Stevenson
Freda K. Stevenson University of Southampton
Paul A. Townsend
Paul A. Townsend University of Manchester
Peter Johnson
Peter Johnson University of Southampton
Arasu Ganesan
Arasu Ganesan University of East Anglia
John L. Cleveland
John L. Cleveland Moffitt Cancer Center
Mark S. Cragg
Mark S. Cragg University of Southampton
Barry V. L. Potter
Barry V. L. Potter University of Oxford
Paul J. Farrell
Paul J. Farrell Imperial College London
Anne E. Willis
Anne E. Willis University of Cambridge
Jude Fitzgibbon
Jude Fitzgibbon Queen Mary University of London

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