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Biology and Biochemistry

D-Index
63
Citations
11965
World Ranking
10392
National Ranking
793

Overview

Paul A. Townsend is affiliated with the University of Manchester in the United Kingdom. Their research spans across multiple fields with a focus on biochemistry, genetics, molecular biology, and medicine. The main subfields of their work include molecular biology, spectroscopy, genetics, pulmonary and respiratory medicine, and oncology.

Their research covers a range of scientific topics, emphasizing genetic associations and epidemiology, prostate cancer treatment and research, mass spectrometry techniques and applications, advanced proteomics techniques, metabolomics and mass spectrometry studies, RNA interference and gene delivery, as well as statistical methods in clinical trials.

Paul A. Townsend has co-authored studies with several frequent collaborators, including Hermann Brenner, Jyotsna Batra, Catharine West, Esther M. John, and Eli Marie Grindedal. Their publications are commonly found in journals and venues such as Hypertension, Cancers, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, and The Journal of Sexual Medicine.

Their recent notable papers demonstrate a focus on cancer biology and genetic epidemiology. These include:

  • 'An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk,' 2020, Nature Communications
  • 'BH3-mimetics: recent developments in cancer therapy,' 2021, Journal of Experimental & Clinical Cancer Research
  • 'Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation,' 2020, International Journal of Cancer
  • 'Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan,' 2020, Nature Communications
  • 'Polygenic hazard score is associated with prostate cancer in multi-ethnic populations,' 2021, Nature Communications

Paul A. Townsend's research integrates molecular biology techniques with clinical applications, particularly in oncology and genetic epidemiology. The work on prostate cancer biomarkers and therapeutics reflects interdisciplinary approaches involving multi-omics analysis and genetic risk assessment in diverse populations.

Their involvement in mass spectrometry and proteomics research indicates expertise in advanced analytical techniques applied to biological systems. This is complemented by studies in pulmonary and respiratory medicine, suggesting a breadth of interest in both molecular and systemic physiological processes.

Best Publications

  • Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

    Fredrick R. Schumacher;Ali Amin Al Olama;Sonja I. Berndt;Sara Benlloch

  • Molecular regulation of cardiac hypertrophy

    Sean P. Barry;Sean M. Davidson;Paul A. Townsend

  • Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

    David V. Conti;Burcu F. Darst;Lilit C. Moss;Edward J. Saunders

  • Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury

    Lauren Valentim;Kevin M. Laurence;Paul A. Townsend;Christopher J. Carroll

  • STAT-1 Interacts with p53 to Enhance DNA Damage-induced Apoptosis

    Paul A. Townsend;Tiziano M. Scarabelli;Sean M. Davidson;Richard A. Knight

  • Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

    Panagiotis Galanos;Konstantinos Vougas;David Walter;Alexander Polyzos

  • An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk.

    Lang Wu;Yaohua Yang;Xingyi Guo;Xiao Ou Shu

  • Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis

    Paul A. Townsend;Paul A. Townsend;Tiziano M. Scarabelli;Evasio Pasini;Gianluca Gitti

  • Robust, universal biomarker assay to detect senescent cells in biological specimens

    Konstantinos Evangelou;Nikolaos Lougiakis;Sophia V. Rizou;Athanassios Kotsinas

  • Role of the JAK–STAT pathway in myocardial injury

    Seán P. Barry;Paul A. Townsend;David S. Latchman;Anastasis Stephanou

  • A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells

    Elena Miranda;Ida K. Nordgren;Abigail L. Male;Charlotte E. Lawrence

  • BAG-1: a multifunctional regulator of cell growth and survival

    Paul A Townsend;Ramsey I Cutress;Adam Sharp;Matthew Brimmell

  • Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO

    Tiziano M. Scarabelli;Anastasis Stephanou;Evasio Pasini;Gianluca Gitti

  • A Deep Learning Framework for Predicting Response to Therapy in Cancer.

    Theodore Sakellaropoulos;Konstantinos Vougas;Konstantinos Vougas;Sonali Narang;Filippos Koinis

  • Clinical Implications of Apoptosis in Ischemic Myocardium

    Tiziano M. Scarabelli;Richard Knight;Anastasis Stephanou;Paul Townsend

  • Identification of markers of prostate cancer progression using candidate gene expression.

    S.E.T. Larkin;S.E.T. Larkin;S. Holmes;I.A. Cree;T. Walker

  • Binding of pulmonary surfactant proteins to carbon nanotubes; potential for damage to lung immune defense mechanisms

    Carolina Salvador-Morales;Paul Townsend;Emmanuel Flahaut;Catherine Vénien-Bryan

  • The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where

    Ioannis S Pateras;Sophia Havaki;Xenia Nikitopoulou;Konstantinos Vougas

  • BAG-1 expression and function in human cancer

    R I Cutress;P A Townsend;P A Townsend;M Brimmell;A C Bateman

  • STAT3 modulates the DNA damage response pathway.

    Seán P. Barry;Paul A. Townsend;Richard A. Knight;Tiziano M. Scarabelli

Frequent Co-Authors

Graham Packham
Graham Packham University of Southampton
Anastasis Stephanou
Anastasis Stephanou European University Cyprus
David S. Latchman
David S. Latchman University College London
David E. Neal
David E. Neal University of Cambridge
Johanna Schleutker
Johanna Schleutker Turku University Hospital
Kenneth W. Muir
Kenneth W. Muir University of Manchester
Janet L. Stanford
Janet L. Stanford Fred Hutchinson Cancer Research Center
Jyotsna Batra
Jyotsna Batra Queensland University of Technology
Graham G. Giles
Graham G. Giles University of Melbourne
Lisa A. Cannon-Albright
Lisa A. Cannon-Albright University of Utah

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