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Anastasis Stephanou

Anastasis Stephanou

D-Index & Metrics

Molecular Biology

D-Index
57
Citations
17516
World Ranking
2130
National Ranking
1

Overview

Anastasis Stephanou is affiliated with the European University Cyprus in Cyprus and conducts research primarily in the fields of biochemistry, genetics, and molecular biology. Their scholarly work spans several interrelated disciplines, including molecular biology, cancer research, modeling and simulation, biomedical engineering, and cell biology.

Their recent publication record includes a variety of topics related to cancer, metabolism, and mathematical biology. Noteworthy papers include:

  • On the Importance of Acidity in Cancer Cells and Therapy (2024, Biology)
  • Searching for the Metabolic Signature of Cancer: A Review from Warburg's Time to Now (2022, Biomolecules)
  • Metabolic Reprogramming, Questioning, and Implications for Cancer (2021, Biology)
  • Characterization of the Intracellular Acidity Regulation of Brain Tumor Cells and Consequences for Therapeutic Optimization of Temozolomide (2023, Biology)
  • Modeling the role of HIF in the regulation of metabolic key genes LDH and PDH: Emergence of Warburg phenotype (2022, Computational and Systems Oncology)

The main research topics covered by their work include:

  • Cancer, Hypoxia, and Metabolism
  • Mathematical Biology Tumor Growth
  • ATP Synthase and ATPases Research
  • Metabolism, Diabetes, and Cancer
  • Mitochondrial Function and Pathology
  • Bioinformatics and Genomic Networks
  • Cellular Mechanics and Interactions

Frequent coauthors collaborating with Anastasis Stephanou are:

  • Pierre Jacquet
  • Gibin Powathil
  • Alaa Tafech
  • Kévin Spinicci
  • Éric Fanchon

Stephanou has published repeatedly in selected academic venues, including:

  • Biology
  • Biomolecules
  • Cancers
  • Mathematical Modelling of Natural Phenomena
  • Computer Methods in Biomechanics & Biomedical Engineering

Their research integrates experimental and computational approaches to understand metabolic pathways and acidity regulation in cancer cells, aiming to explore therapeutic implications and mathematical modeling of tumor growth. This interdisciplinary focus is evident in the merging of biochemical and engineering techniques in the study of cancer metabolism and cellular microenvironments.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Apoptosis of Endothelial Cells Precedes Myocyte Cell Apoptosis in Ischemia/Reperfusion Injury

    Tiziano Scarabelli;Anastasis Stephanou;Neil Rayment;Evasio Pasini

  • Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury

    Lauren Valentim;Kevin M. Laurence;Paul A. Townsend;Christopher J. Carroll

  • STAT-1 Interacts with p53 to Enhance DNA Damage-induced Apoptosis

    Paul A. Townsend;Tiziano M. Scarabelli;Sean M. Davidson;Richard A. Knight

  • Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway.

    Bhawanjit K. Brar;Anna K. Jonassen;Anastasis Stephanou;Giorgia Santilli

  • Ischemia-induced STAT-1 Expression and Activation Play a Critical Role in Cardiomyocyte Apoptosis

    Anastasis Stephanou;Bhawanjit K. Brar;Tiziano M. Scarabelli;Anna K. Jonassen

  • Induction of Apoptosis and Fas Receptor/Fas Ligand Expression by Ischemia/Reperfusion in Cardiac Myocytes Requires Serine 727 of the STAT-1 Transcription Factor but Not Tyrosine 701

    Anastasis Stephanou;Tiziano M. Scarabelli;Bhawanjit K. Brar;Yoshinobu Nakanishi

  • Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis

    Paul A. Townsend;Paul A. Townsend;Tiziano M. Scarabelli;Evasio Pasini;Gianluca Gitti

  • Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters.

    A Stephanou;B K Brar;R A Knight;D S Latchman

  • Different Signaling Pathways Induce Apoptosis in Endothelial Cells and Cardiac Myocytes During Ischemia/Reperfusion Injury

    Tiziano M. Scarabelli;Anastasis Stephanou;Evasio Pasini;Laura Comini

  • Role of the JAK–STAT pathway in myocardial injury

    Seán P. Barry;Paul A. Townsend;David S. Latchman;Anastasis Stephanou

  • Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO

    Tiziano M. Scarabelli;Anastasis Stephanou;Evasio Pasini;Gianluca Gitti

  • Opposing actions of STAT-1 and STAT-3.

    A Stephanou;D S Latchman

  • STAT-1: a novel regulator of apoptosis.

    Anastasis Stephanou;David S. Latchman

  • Heat shock proteins delivered with a virus vector can protect cardiac cells against apoptosis as well as against thermal or hypoxic stress.

    B.K. Brar;A. Stephanou;M.J.D. Wagstaff;R.S. Coffin

  • Corticotrophin-releasing factor-like immunoreactivity and mRNA in human leukocytes.

    A Stephanou;D S Jessop;R A Knight;S L Lightman

  • The effects of recombinant human interleukin (IL)-1α, IL-1β or IL-6 on hypothalamo-pituitary-adrenal axis activation

    M. S. Harbuz;A. Stephanou;N. Sarlis;S. L. Lightman

  • Activation of Protein Kinase B/Akt by Urocortin is Essential for its Ability to Protect Cardiac Cells Against Hypoxia/Reoxygenation-induced Cell Death

    Bhawanjit K. Brar;Anastasis Stephanou;Richard Knight;David S. Latchman

  • Signal Transducer and Activator of Transcription-1 and Heat Shock Factor-1 Interact and Activate the Transcription of the Hsp-70 and Hsp-90β Gene Promoters

    Anastasis Stephanou;David A. Isenberg;Koichi Nakajima;David S. Latchman

  • Expression and protective effects of urocortin in cardiac myocytes

    A Okosi;B.K Brar;M Chan;L D'Souza

Frequent Co-Authors

David S. Latchman
David S. Latchman University College London
Richard A. Knight
Richard A. Knight University College London
Paul A. Townsend
Paul A. Townsend University of Manchester
Sean M. Davidson
Sean M. Davidson University College London
David A. Isenberg
David A. Isenberg University College London
Gerry Melino
Gerry Melino University of Rome Tor Vergata
Mike Hubank
Mike Hubank Royal Marsden NHS Foundation Trust
Derek M. Yellon
Derek M. Yellon University College London
Jagat Narula
Jagat Narula Icahn School of Medicine at Mount Sinai
Christoph Thiemermann
Christoph Thiemermann Queen Mary University of London

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