World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
129
Citations
90966
World Ranking
411
National Ranking
266

Medicine

D-Index
129
Citations
91121
World Ranking
2528
National Ranking
1424

Overview

Junichi Sadoshima is affiliated with Rutgers, The State University of New Jersey in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on molecular mechanisms relevant to cardiovascular health and disease.

The scientist has published extensively in several key areas of study, including the following subfields:

  • Molecular Biology
  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Epidemiology
  • Cell Biology

The main topics of Sadoshima's research include:

  • Autophagy in Disease and Therapy
  • Mitochondrial Function and Pathology
  • Adipose Tissue and Metabolism
  • Cardiovascular Function and Risk Factors
  • Hippo pathway signaling and YAP/TAZ
  • Cardiac Ischemia and Reperfusion
  • Calcium signaling and nucleotide metabolism

Sadoshima has contributed to numerous publications in prominent scientific journals. Frequent publication venues include:

  • Circulation Research
  • Circulation
  • Journal of Molecular and Cellular Cardiology
  • Cardiovascular Research
  • JACC Basic to Translational Science

Some of the recent papers authored or co-authored by Sadoshima are:

  • "International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis," 2024, published in Autophagy
  • "Autophagy in major human diseases," 2021, published in The EMBO Journal
  • "The role of Drp1 in mitophagy and cell death in the heart," 2020, published in Journal of Molecular and Cellular Cardiology
  • "Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury," 2020, published in Journal of Clinical Investigation
  • "KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy," 2020, published in Circulation Research

Frequent collaborators include:

  • Peiyong Zhai
  • Shinichi Oka
  • Eun-Ah Sung
  • Risa Mukai
  • Jihoon Nah

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.

    Jun Ichi Sadoshima;Seigo Izumo

  • Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

    Jun Ichi Sadoshima;Yuhui Xu;Henry S. Slayter;Seigo Izumo

  • Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy

    Yutaka Matsui;Hiromitsu Takagi;Xueping Qu;Maha Abdellatif

  • Autophagy in major human diseases

    Daniel J. Klionsky;Giulia Petroni;Ravi K. Amaravadi;Eric H. Baehrecke

  • Mechanisms of physiological and pathological cardiac hypertrophy

    Michinari Nakamura;Junichi Sadoshima

  • THE CELLULAR AND MOLECULAR RESPONSE OF CARDIAC MYOCYTES TO MECHANICAL STRESS

    Junichi Sadoshima;Seigo Izumo

  • Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart

    Ralph R. Alcendor;Shumin Gao;Peiyong Zhai;Daniela Zablocki

  • Cardioprotection and lifespan extension by the natural polyamine spermidine

    Tobias Eisenberg;Mahmoud Abdellatif;Sabrina Schroeder;Uwe Primessnig;Uwe Primessnig

  • Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

    J.-I. Sadoshima;S. Izumo

  • NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

    Junya Kuroda;Tetsuro Ago;Shouji Matsushima;Peiyong Zhai

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy.

    J.-I. Sadoshima;L. Jahn;T. Takahashi;T. J. Kulik

  • Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction

    Weiping Qin;Tianle Yang;Lap Ho;Lap Ho;Zhong Zhao

  • Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes

    Shweta Rane;Minzhen He;Danish Sayed;Himanshu Vashistha

  • AUTOPHAGY IN CHRONICALLY ISCHEMIC MYOCARDIUM

    Lin Yan;Dorothy E. Vatner;Song-Jung Kim;Hui Ge

  • Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes

    Nirmala Hariharan;Yasuhiro Maejima;Jun Nakae;Jihye Paik

Frequent Co-Authors

Dorothy E. Vatner
Dorothy E. Vatner Rutgers, The State University of New Jersey
Stephen F. Vatner
Stephen F. Vatner Rutgers, The State University of New Jersey
Seigo Izumo
Seigo Izumo Beth Israel Deaconess Medical Center
Hong Li
Hong Li Rutgers, The State University of New Jersey
Bin Tian
Bin Tian The Wistar Institute
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Massimo Volpe
Massimo Volpe Sapienza University of Rome
Guido Kroemer
Guido Kroemer Université Paris Cité
Hiroyuki Tsutsui
Hiroyuki Tsutsui Kyushu University
Joseph A. Hill
Joseph A. Hill The University of Texas Southwestern Medical Center

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