His primary areas of study are Internal medicine, Endocrinology, Cell biology, Signal transduction and Muscle hypertrophy. His Internal medicine research incorporates themes from Endothelial stem cell, Gene expression and Myosin. His Endocrinology study integrates concerns from other disciplines, such as Downregulation and upregulation and Growth factor.
His Cell biology research is multidisciplinary, incorporating elements of Phenotype, Molecular biology and Programmed cell death. As part of the same scientific family, Seigo Izumo usually focuses on Signal transduction, concentrating on Autocrine signalling and intersecting with Mediator. In his study, Heat shock protein, Cardiac Myosins and Tropomyosin is inextricably linked to Skeletal muscle, which falls within the broad field of Muscle hypertrophy.
His primary areas of investigation include Internal medicine, Endocrinology, Cell biology, Molecular biology and Myocyte. His Internal medicine research integrates issues from PI3K/AKT/mTOR pathway and Cardiology. The various areas that Seigo Izumo examines in his Endocrinology study include Cardiac function curve, Genetically modified mouse, Signal transduction and Gene expression.
His Cell biology research is multidisciplinary, incorporating perspectives in Regulation of gene expression, Myofibril, Cellular differentiation and Microfilament. The Molecular biology study combines topics in areas such as Homeobox, Transcription factor, Gene, Gene isoform and Binding site. The concepts of his Muscle hypertrophy study are interwoven with issues in Cardiac muscle, Left ventricular hypertrophy, Downregulation and upregulation, Circulatory system and Diastole.
Seigo Izumo mainly focuses on Internal medicine, Endocrinology, PI3K/AKT/mTOR pathway, Cell biology and Protein kinase B. While the research belongs to areas of Internal medicine, Seigo Izumo spends his time largely on the problem of Cardiology, intersecting his research to questions surrounding P110α. The study incorporates disciplines such as Genetically modified mouse, Signal transduction and Transcription factor in addition to Endocrinology.
His Mesoderm formation and Stem cell study in the realm of Cell biology connects with subjects such as Electrical conduction system of the heart and Embryoid body. His Protein kinase B study incorporates themes from Anesthesia and Protein kinase C, Kinase. His Cardiac function curve study combines topics in areas such as Fibrosis and Dilated cardiomyopathy.
Seigo Izumo mainly investigates Fibrosis, Pressure overload, Muscle hypertrophy, Internal medicine and Dilated cardiomyopathy. His research in Fibrosis intersects with topics in Mesenchymal stem cell, Extracellular matrix and Bone morphogenetic protein 7, Bone morphogenetic protein. His Pressure overload research is multidisciplinary, relying on both Embryonic heart and Cardiac fibrosis.
His research integrates issues of Circulatory system, Everolimus and Sirolimus in his study of Muscle hypertrophy. His PI3K/AKT/mTOR pathway research extends to Internal medicine, which is thematically connected. His work deals with themes such as Cardiac function curve, Hypertrophic cardiomyopathy, Heart disease and Endocrinology, which intersect with Dilated cardiomyopathy.
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Hemodynamic shear stress and its role in atherosclerosis.
Adel M. Malek;Seth L. Alper;Seigo Izumo.
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
Elisabeth M Zeisberg;Oleg Tarnavski;Michael Zeisberg;Adam L Dorfman.
Nature Medicine (2007)
Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.
Jun Ichi Sadoshima;Seigo Izumo.
Circulation Research (1993)
Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro
Jun Ichi Sadoshima;Yuhui Xu;Henry S. Slayter;Seigo Izumo.
THE CELLULAR AND MOLECULAR RESPONSE OF CARDIAC MYOCYTES TO MECHANICAL STRESS
Junichi Sadoshima;Seigo Izumo.
Annual Review of Physiology (1997)
Apoptosis: Basic Mechanisms and Implications for Cardiovascular Disease
Armin Haunstetter;Seigo Izumo.
Circulation Research (1998)
Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload
Seigo Izumo;Bernardo Nadal-Ginard;Vijak Mahdavi.
Proceedings of the National Academy of Sciences of the United States of America (1988)
Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.
J.-I. Sadoshima;S. Izumo.
The EMBO Journal (1993)
Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy.
J.-I. Sadoshima;L. Jahn;T. Takahashi;T. J. Kulik.
Journal of Biological Chemistry (1992)
All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner
Seigo Izumo;Bernardo Nadal-Ginard;Vijak Mahdavi.
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