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Vincent M. Christoffels

Vincent M. Christoffels

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
20873
World Ranking
4348
National Ranking
103

Overview

Vincent M. Christoffels is affiliated with the University of Amsterdam in the Netherlands. Their research focuses extensively on biochemistry, genetics, and molecular biology, with substantial contributions to the fields of medicine and cardiology. The primary areas of study include molecular biology, cardiology and cardiovascular medicine, epidemiology, cellular and molecular neuroscience, and genetics.

The scientist's work covers multiple main research topics: congenital heart defects research, cardiomyopathy and myosin studies, congenital heart disease studies, cardiac electrophysiology and arrhythmias, RNA research and splicing, CRISPR and genetic engineering, and cardiovascular function and risk factors.

Vincent M. Christoffels has authored numerous papers, some of which include:

  • Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation, 2020, Circulation Research
  • Sodium Glucose Cotransporter-2 Inhibitor Empagliflozin Reduces Infarct Size Independently of Sodium Glucose Cotransporter-2, 2023, Circulation
  • Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells, 2021, Stem Cell Reports
  • Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart, 2020, Circulation Research
  • Cardiac Morphogenesis: Specification of the Four-Chambered Heart, 2020, Cold Spring Harbor Perspectives in Biology

Frequent collaborators in their research include Gerard J.J. Boink, Arie O. Verkerk, Fernanda M. Bosada, Karel van Duijvenboden, and Mischa Klerk.

The scientist publishes regularly in several research venues with high volume contributions to:

  • Cardiovascular Research
  • Heart Rhythm
  • Circulation Research
  • European Heart Journal
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Cardiac Chamber Formation: Development, Genes, and Evolution

    Antoon F. M. Moorman;Vincent M. Christoffels

  • Chamber formation and morphogenesis in the developing mammalian heart.

    Vincent M. Christoffels;Petra E.M.H. Habets;Diego Franco;Marina Campione

  • Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

    Connie R Bezzina;Julien Barc;Yuka Mizusawa;Carol Ann Remme

  • Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

    Willem M.H. Hoogaars;Angela Engel;Janynke F. Brons;Arie O. Verkerk

  • Lineage and Morphogenetic Analysis of the Cardiac Valves

    Frederik J. de Lange;Antoon F.M. Moorman;Robert H. Anderson;Jörg Männer

  • Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation

    Petra E.M.H. Habets;Antoon F.M. Moorman;Danielle E.W. Clout;Marian A. van Roon

  • Molecular Pathway for the Localized Formation of the Sinoatrial Node

    Mathilda T.M. Mommersteeg;Willem M.H. Hoogaars;Owen W.J. Prall;Corrie de Gier-de Vries

  • The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart

    Willem M.H Hoogaars;Alessandra Tessari;Antoon F.M Moorman;Piet A.J de Boer

  • Formation of the Sinus Node Head and Differentiation of Sinus Node Myocardium Are Independently Regulated by Tbx18 and Tbx3

    Cornelia Wiese;Thomas Grieskamp;Rannar Airik;Mathilda T.M. Mommersteeg

  • Formation of the Venous Pole of the Heart From an Nkx2–5–Negative Precursor Population Requires Tbx18

    Vincent M. Christoffels;Mathilda T.M. Mommersteeg;Mark-Oliver Trowe;Owen W.J. Prall

  • Sensitive Nonradioactive Detection of mRNA in Tissue Sections: Novel Application of the Whole-mount In Situ Hybridization Protocol:

    Antoon F. M. Moorman;Arjan C. Houweling;Piet A. J. de Boer;Vincent M. Christoffels

  • Development of the Pacemaker Tissues of the Heart

    Vincent M. Christoffels;Gertien J. Smits;Andreas Kispert;Antoon F. M. Moorman

  • T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers.

    Vincent M. Christoffels;Willem M.H. Hoogaars;Alessandra Tessari;Danielle E.W. Clout

  • The formation and function of the cardiac conduction system

    Jan Hendrik van Weerd;Vincent M. Christoffels

  • Transcription Factor Tbx3 Is Required for the Specification of the Atrioventricular Conduction System

    Martijn L. Bakker;Bastiaan J. Boukens;Mathilda T.M. Mommersteeg;Janynke F. Brons

  • Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

    Malou van den Boogaard;L.Y. Elaine Wong;Federico Tessadori;Martijn L. Bakker

  • A common genetic variant within SCN10A modulates cardiac SCN5A expression

    Malou van den Boogaard;Scott Smemo;Ozanna Burnicka-Turek;David E. Arnolds

  • The sinus venosus progenitors separate and diversify from the first and second heart fields early in development.

    Mathilda T.M. Mommersteeg;Jorge N. Domínguez;Cornelia Wiese;Julia Norden

  • Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart

    Vincent M. Christoffels;Astrid G.M. Keijser;Arjan C. Houweling;Danielle E.W. Clout

  • A Gain-of-Function TBX5 Mutation Is Associated With Atypical Holt–Oram Syndrome and Paroxysmal Atrial Fibrillation

    Alex V. Postma;Judith B.A. van de Meerakker;Inge B. Mathijssen;Phil Barnett

Frequent Co-Authors

Antoon F.M. Moorman
Antoon F.M. Moorman University of Amsterdam
Andreas Kispert
Andreas Kispert Hannover Medical School
Jeroen Bakkers
Jeroen Bakkers Utrecht University
Connie R. Bezzina
Connie R. Bezzina University of Amsterdam
Robert H. Anderson
Robert H. Anderson Newcastle University
Maurice J.B. van den Hoff
Maurice J.B. van den Hoff University of Amsterdam
James F. Martin
James F. Martin Baylor College of Medicine
Wouter H. Lamers
Wouter H. Lamers Maastricht University
Patrick T. Ellinor
Patrick T. Ellinor Harvard University
Axel Visel
Axel Visel Lawrence Berkeley National Laboratory

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