World's Best Scientists 2026 revealed!

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Biology and Biochemistry

D-Index
95
Citations
30540
World Ranking
1917
National Ranking
1052

Medicine

D-Index
96
Citations
30696
World Ranking
9754
National Ranking
5016

Research.com Recognitions

  • 2013 - E. Mead Johnson Award, Society for Pediatric Research

Overview

William T. Pu is affiliated with Boston Children's Hospital in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans several subfields, including molecular biology, cardiology and cardiovascular medicine, genetics, surgery, and cell biology.

Pu's research focuses on multiple topics, notably congenital heart defects research, cardiomyopathy and myosin studies, CRISPR and genetic engineering, cardiac electrophysiology and arrhythmias, RNA research and splicing, viral infections and immunology research, and mitochondrial function and pathology.

Recent papers authored by Pu highlight a range of research areas:

  • "Cardiomyocyte Maturation," 2020, Circulation Research
  • "Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles," 2023, Nature Materials
  • "Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA," 2020, Science Advances
  • "Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease," 2020, Developmental Cell
  • "AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome," 2020, Circulation Research

Pu collaborates frequently with several researchers, including Vassilios J. Bezzerides, Qing Ma, Michael A. Trembley, Yuxuan Guo, and Maksymilian Prondzynski. These collaborations reflect an active engagement in interdisciplinary and multi-author projects.

Their work has been published in various journals, with recurrent contributions to bioRxiv (Cold Spring Harbor Laboratory), Circulation Research, Circulation, Nature Communications, and Nature Cardiovascular Research.

Pu received the E. Mead Johnson Award from the Society for Pediatric Research in 2013, acknowledging contributions in their field.

Best Publications

  • Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

    Elisabeth M Zeisberg;Oleg Tarnavski;Michael Zeisberg;Adam L Dorfman

  • Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart

    Bin Zhou;Qing Ma;Qing Ma;Satish Rajagopal;Satish Rajagopal;Sean M. Wu

  • Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

    Gang Wang;Megan L. McCain;Luhan Yang;Aibin He

  • Altered microRNA expression in human heart disease

    Sadakatsu Ikeda;Sek Won Kong;Jun Lu;Egbert Bisping

  • De novo cardiomyocytes from within the activated adult heart after injury

    Nicola Smart;Sveva Bollini;Karina N. Dubé;Joaquim M. Vieira

  • Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction.

    Lior Zangi;Kathy O Lui;Kathy O Lui;Alexander von Gise;Alexander von Gise;Qing Ma;Qing Ma

  • YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy

    Alexander von Gise;Zhiqiang Lin;Karin Schlegelmilch;Leah B. Honor

  • Adult mouse epicardium modulates myocardial injury by secreting paracrine factors

    Bin Zhou;Leah B. Honor;Huamei He;Qing Ma

  • Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association.

    Mary Ella Pierpont;Martina Brueckner;Wendy K Chung;Vidu Garg

  • MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes.

    Sadakatsu Ikeda;Aibin He;Sek Won Kong;Jun Lu

  • Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin

    James J.H. Chong;Vashe Chandrakanthan;Vashe Chandrakanthan;Munira Xaymardan;Munira Xaymardan;Munira Xaymardan;Naisana S. Asli

  • Cardiomyocyte Maturation: New Phase in Development.

    Yuxuan Guo;William T Pu

  • Endocardial and Epicardial Epithelial to Mesenchymal Transitions in Heart Development and Disease

    Alexander von Gise;William T. Pu

  • Single-Cell Resolution of Temporal Gene Expression during Heart Development.

    Daniel M. DeLaughter;Alexander G. Bick;Hiroko Wakimoto;David McKean

  • Recounting Cardiac Cellular Composition

    Pingzhu Zhou;William T. Pu

  • Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart

    Aibin He;Sek Won Kong;Qing Ma;William T. Pu

  • Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model

    Zhiqiang Lin;Alexander von Gise;Pingzhu Zhou;Fei Gu

  • Septum Transversum-Derived Mesothelium Gives Rise to Hepatic Stellate Cells and Perivascular Mesenchymal Cells in Developing Mouse Liver

    Kinji Asahina;Bin Zhou;Bin Zhou;William T. Pu;William T. Pu;Hidekazu Tsukamoto;Hidekazu Tsukamoto

  • Morphogenesis of the right ventricle requires myocardial expression of Gata4

    Elisabeth M. Zeisberg;Qing Ma;Amy L. Juraszek;Kelvin Moses

  • PRC2 directly methylates GATA4 and represses its transcriptional activity

    Aibin He;Xiaohua Shen;Qing Ma;Jingjing Cao

Frequent Co-Authors

Bin Zhou
Bin Zhou Chinese Academy of Sciences
Da-Zhi Wang
Da-Zhi Wang Boston Children's Hospital
Christine E. Seidman
Christine E. Seidman Harvard University
Jonathan G. Seidman
Jonathan G. Seidman Harvard University
Seigo Izumo
Seigo Izumo Beth Israel Deaconess Medical Center
Guo-Cheng Yuan
Guo-Cheng Yuan Icahn School of Medicine at Mount Sinai
Stuart H. Orkin
Stuart H. Orkin Harvard University
David E. Clapham
David E. Clapham Howard Hughes Medical Institute
George M. Church
George M. Church Harvard University
Christer Betsholtz
Christer Betsholtz Uppsala University

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