World's Best Scientists 2026 revealed!
Kenneth R. Chien

Kenneth R. Chien

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Biology and Biochemistry
Sweden
2026
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Medicine
Sweden
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
146
Citations
75007
World Ranking
209
National Ranking
4

Medicine

D-Index
147
Citations
75416
World Ranking
1297
National Ranking
26

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Sweden Leader Award
  • 2025 - Research.com Biology and Biochemistry in Sweden Leader Award
  • 2023 - Research.com Biology and Biochemistry in Sweden Leader Award
  • 2023 - Research.com Medicine in Sweden Leader Award
  • 2022 - Research.com Biology and Biochemistry in Sweden Leader Award
  • 1995 - Robert J. and Claire Pasarow Foundation Medical Research Award

Overview

Kenneth R. Chien is affiliated with the Karolinska Institute in Sweden, with a research focus at the intersection of biochemistry, genetics, molecular biology, and medicine. Their work spans several specialized subfields including molecular biology, cardiology and cardiovascular medicine, surgery, genetics, and biomaterials.

The scientist's research primarily addresses topics related to congenital heart defects, pluripotent stem cells, single-cell and spatial transcriptomics, tissue engineering and regenerative medicine, cardiac fibrosis and remodeling, RNA interference and gene delivery, and the application of electrospun nanofibers in biomedical contexts.

Among recent publications, notable papers include:

  • Unlocking the promise of mRNA therapeutics, 2022, Nature Biotechnology
  • Amnion signals are essential for mesoderm formation in primates, 2021, Nature Communications
  • BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways, 2021, Communications Biology
  • Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy, 2021, Nature Communications
  • VEGFA mRNA for regenerative treatment of heart failure, 2021, Nature Reviews Drug Discovery

Chien has frequently collaborated with the following researchers:

  • Nevin Witman (11 co-authored papers)
  • Chikai Zhou (7 co-authored papers)
  • Regina Fritsche-Danielson (7 co-authored papers)
  • Makoto Sahara (7 co-authored papers)
  • Eduarde Rohner (5 co-authored papers)

The scientist's work has been published predominantly in the following venues:

  • Nature Communications (6 publications)
  • Molecular Therapy (3 publications)
  • Nature Cell Biology (3 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (2 publications)
  • Stem Cells (2 publications)

Kenneth R. Chien's research contributions lie mainly in the fields of biochemistry, genetics, and molecular biology with 46 publications, supplemented by 23 publications in the field of medicine. Their scholarly output reflects extensive engagement in molecular biology as well as cardiovascular medicine and surgical research.

In 1995, Chien received the Robert J. and Claire Pasarow Foundation Medical Research Award.

Best Publications

  • PPAR gamma is required for placental, cardiac, and adipose tissue development.

    Yaacov Barak;Michael C Nelson;Michael C Nelson;Estelita S Ong;Estelita S Ong;Ying Z Jones

  • Postnatal isl1 + cardioblasts enter fully differentiated cardiomyocyte lineages

    Karl Ludwig Laugwitz;Alessandra Moretti;Jason Lam;Peter Gruber

  • Multipotent Embryonic Isl1+ Progenitor Cells Lead to Cardiac, Smooth Muscle, and Endothelial Cell Diversification

    Alessandra Moretti;Leslie Caron;Atsushi Nakano;Jason T. Lam;Jason T. Lam

  • Signaling Pathways for Cardiac Hypertrophy and Failure

    John J. Hunter;Kenneth R. Chien

  • Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart

    Bin Zhou;Qing Ma;Qing Ma;Satish Rajagopal;Satish Rajagopal;Sean M. Wu

  • Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

    Yibin Wang;Shuang Huang;Valerie P. Sah;John Ross

  • ErbB2 is essential in the prevention of dilated cardiomyopathy

    Steven A. Crone;You Yang Zhao;Lian Fan;Yusu Gu

  • Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response.

    K. R. Chien;K. U. Knowlton;Hong Zhu;Shu Chien

  • MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure

    Silvia Arber;John J Hunter;John Ross;Minoru Hongo

  • Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy

    Howard A. Rockman;Robert S. Ross;Adrienne N. Harris;Kirk U. Knowlton

  • Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy.

    H E Shubeita;P M McDonough;A N Harris;K U Knowlton

  • IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.

    Hideo Yasukawa;Masanobu Ohishi;Hiroyuki Mori;Masaaki Murakami

  • Marked differences in differentiation propensity among human embryonic stem cell lines

    Kenji Osafune;Kenji Osafune;Leslie Caron;Malgorzata Borowiak;Malgorzata Borowiak;Rita J Martinez;Rita J Martinez

  • The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy

    Ralph Knöll;Masahiko Hoshijima;Hal M. Hoffman;Veronika Person

  • Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor

    C. A. Milano;L. F. Allen;H. A. Rockman;P. C. Dolber

  • Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

    Gang Wang;Megan L. McCain;Luhan Yang;Aibin He

  • Conduction Slowing and Sudden Arrhythmic Death in Mice With Cardiac-Restricted Inactivation of Connexin43

    David E. Gutstein;Gregory E. Morley;Houman Tamaddon;Dhananjay Vaidya

  • Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

    Hisao Hirota;Ju Chen;Ulrich A.K Betz;Klaus Rajewsky

  • Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.

    D Pennica;K L King;K J Shaw;E Luis

  • Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein

    Yibin Wang;Shuang Huang;Valerie P. Sah;Joan Heller Brown

Frequent Co-Authors

John Ross
John Ross University of California, San Diego
Ju Chen
Ju Chen University of California, San Diego
Yibin Wang
Yibin Wang University of California, Los Angeles
L. M. Buja
L. M. Buja The University of Texas Health Science Center at Houston
John Ross
John Ross University of Tasmania
Joan Heller Brown
Joan Heller Brown University of California, San Diego
Diane Pennica
Diane Pennica Genentech
Howard A. Rockman
Howard A. Rockman Duke University
Sylvia M. Evans
Sylvia M. Evans University of Montana
Ronald A. Li
Ronald A. Li University of Hong Kong

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