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Biology and Biochemistry

D-Index
65
Citations
16002
World Ranking
9114
National Ranking
4048

Overview

Pearlly S. Yan is a researcher affiliated with The Ohio State University in the United States. Their work primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in subfields such as Molecular Biology, Genetics, Immunology, Oncology, and Neurology.

The scientist has produced multiple publications covering topics including Chronic Lymphocytic Leukemia Research, Neuroinflammation and Neurodegeneration Mechanisms, Immune cells in cancer, Epigenetics and DNA Methylation, Advanced Breast Cancer Therapies, Lymphoma Diagnosis and Treatment, and Cancer-related gene regulation.

Key research articles by Pearlly S. Yan include:

  • Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer, 2020, Microbiome
  • Targeting OCT3 attenuates doxorubicin-induced cardiac injury, 2021, Proceedings of the National Academy of Sciences
  • Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelial-mesenchymal transition, 2022, Journal of Clinical Investigation
  • VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia, 2022, Leukemia
  • PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia, 2021, Blood

Frequent co-authors collaborating with Pearlly S. Yan include Ralf Bundschuh, Rosa Lapalombella, Steven Sher, Larry Beaver, and James S. Blachly.

The scientist's research has appeared regularly in several publication venues, with the most frequent being:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Journal of Clinical Investigation
  • Nature Communications

Best Publications

  • Identification and characterization of ovarian cancer-initiating cells from primary human tumors.

    Shu Zhang;Curt Balch;Michael W. Chan;Hung Cheng Lai

  • Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis

    Amy S. Weinmann;Pearlly S. Yan;Matthew J. Oberley;Tim Hui Ming Huang

  • A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis

    Gira Bhabha;Jeeyeon Lee;Damian C. Ekiert;Jongsik Gam

  • Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

    Gi Bang Koo;Michael J. Morgan;Da Gyum Lee;Woo Jung Kim

  • Methylation-Specific Oligonucleotide Microarray: A New Potential for High-Throughput Methylation Analysis

    Raad S. Gitan;Huidong Shi;Chuan Mu Chen;Pearlly S. Yan

  • Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis.

    Yan Wu;Gloria Halverson;Zainab Basir;Estil Strawn

  • Dissecting Complex Epigenetic Alterations in Breast Cancer Using CpG Island Microarrays

    Pearlly S. Yan;Chuan-Mu Chen;Huidong Shi;Farahnaz Rahmatpanah

  • LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability.

    Marcos R.H. Estécio;Vazganush Gharibyan;Lanlan Shen;Ashraf E.K. Ibrahim

  • Epigenetic Profiling of Cutaneous T-Cell Lymphoma: Promoter Hypermethylation of Multiple Tumor Suppressor Genes Including BCL7a, PTPRG, and p73

    Remco van Doorn;Willem H. Zoutman;Remco Dijkman;Renee X. de Menezes

  • Diverse Gene Expression and DNA Methylation Profiles Correlate with Differential Adaptation of Breast Cancer Cells to the Antiestrogens Tamoxifen and Fulvestrant

    Meiyun Fan;Pearlly S. Yan;Cori Hartman-Frey;Lei Chen

  • Epigenetic Regulation of miR-17∼92 Contributes to the Pathogenesis of Pulmonary Fibrosis

    Duaa Dakhlallah;Kara Batte;Yijie Wang;Carmen Z. Cantemir-Stone

  • Mutations in U4atac snRNA, a Component of the Minor Spliceosome, in the Developmental Disorder MOPD I

    Huiling He;Sandya Liyanarachchi;Keiko Akagi;Rebecca Nagy

  • Identification of novel DNA methylation markers in cervical cancer.

    Hung Cheng Lai;Ya Wen Lin;Tim H M Huang;Pearlly Yan

  • Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression.

    Daniel Y.L. Mao;Daniel Y.L. Mao;John D. Watson;Pearlly S. Yan;Dalia Barsyte-Lovejoy;Dalia Barsyte-Lovejoy

  • Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer

    Meng Li;Curt Balch;John S Montgomery;Mikyoung Jeong

  • Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue.

    Pearlly S. Yan;Chinnambally Venkataramu;Ashraf Ibrahim;Joseph C. Liu

  • Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers

    Susan H. Wei;Chuan Mu Chen;Gordon Strathdee;Jaturon Harnsomburana

  • High-throughput methylation profiling by MCA coupled to CpG island microarray

    Marcos R H Estécio;Pearlly S. Yan;Ashraf E K Ibrahim;Carmen S. Tellez

  • Expression and prognostic impact of lncRNAs in acute myeloid leukemia.

    Ramiro Garzon;Stefano Volinia;Dimitrios Papaioannou;Deedra Nicolet

  • Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer

    Yu Wei Leu;Pearlly S. Yan;Meiyun Fan;Victor X. Jin

Frequent Co-Authors

Tim H M Huang
Tim H M Huang The University of Texas Health Science Center at San Antonio
Kenneth P. Nephew
Kenneth P. Nephew Indiana University
John C. Byrd
John C. Byrd University of Pittsburgh Cancer Institute
Guido Marcucci
Guido Marcucci City Of Hope National Medical Center
Huidong Shi
Huidong Shi Augusta University
Ramana V. Davuluri
Ramana V. Davuluri Stony Brook University
Victor X. Jin
Victor X. Jin Medical College of Wisconsin
Sandya Liyanarachchi
Sandya Liyanarachchi The Ohio State University
Michael A. Caligiuri
Michael A. Caligiuri City Of Hope National Medical Center
Christoph Plass
Christoph Plass German Cancer Research Center

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