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Toshikazu Ushijima

Toshikazu Ushijima

D-Index & Metrics

Genetics

D-Index
88
Citations
25846
World Ranking
1178
National Ranking
45

Medicine

D-Index
88
Citations
26363
World Ranking
13239
National Ranking
391

Overview

Toshikazu Ushijima is affiliated with the National Cancer Centre in Japan and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. The main focus of their research lies in molecular biology, with significant work related to cancer research, genetics, and pulmonary and respiratory medicine.

Their primary research topics include:

  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Cancer-related gene regulation
  • Helicobacter pylori-related gastroenterology studies
  • Cancer-related molecular mechanisms research
  • Gastric Cancer Management and Outcomes
  • Cancer Genomics and Diagnostics

Ushijima has been published in several frequent venues, including:

  • Cancer Research
  • Journal of Gastroenterology
  • Gastric Cancer
  • Breast Cancer Research and Treatment
  • Neuro-Oncology

They have collaborated regularly with a group of co-authors, often working with Satoshi Yamashita, Naoko Hattori, Hideyuki Takeshima, Yuyu Liu, and Chihiro Takeuchi.

Among Ushijima's most notable recent papers are:

  • "Hereditary diffuse gastric cancer: updated clinical practice guidelines," 2020, The Lancet Oncology
  • "TET repression and increased DNMT activity synergistically induce aberrant DNA methylation," 2020, Journal of Clinical Investigation
  • "Mapping genomic and epigenomic evolution in cancer ecosystems," 2021, Science
  • "Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis by using the new oral demethylating agent OR-2100," 2020, Blood
  • "12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors," 2021, Neuro-Oncology

Their research contributions span the study of DNA methylation and epigenetic modifications influencing cancer development and progression. This includes investigations into molecular mechanisms underpinning gene regulation in cancer cells and the relationship between infection and gastric diseases.

The body of work spans nearly a hundred publications in biochemistry, genetics, and molecular biology, reflecting sustained engagement with understanding cancer's molecular and cellular foundations.

Best Publications

  • Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer

    Qing Lin Li;Kosei Ito;Chohei Sakakura;Hiroshi Fukamachi

  • High Levels of Aberrant DNA Methylation in Helicobacter pylori–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk

    Takao Maekita;Kazuyuki Nakazawa;Mami Mihara;Takeshi Nakajima

  • Detection and interpretation of altered methylation patterns in cancer cells

    Toshikazu Ushijima

  • The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

    Hendrik G. Stunnenberg;Martin Hirst

  • Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells.

    Tohru Niwa;Tetsuya Tsukamoto;Takeshi Toyoda;Akiko Mori

  • Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation.

    Tsutomu Chiba;Hiroyuki Marusawa;Toshikazu Ushijima

  • Epigenetic mechanisms of chronic pain

    Giannina Descalzi;Daigo Ikegami;Toshikazu Ushijima;Eric J. Nestler

  • Hereditary Diffuse Gastric Cancer: Updated Clinical Practice Guidelines

    Vanessa R. Blair;Maybelle McLeod;Fátima Carneiro;Daniel G. Coit

  • Focus on gastric cancer.

    Toshikazu Ushijima;Mitsuru Sasako

  • DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect.

    Takayuki Ando;Takeichi Yoshida;Shotaro Enomoto;Kiyoshi Asada

  • Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.

    Satoshi Yamashita;Yoshimi Tsujino;Kazuki Moriguchi;Masae Tatematsu

  • Silencing of the thrombomodulin gene in human malignant melanoma.

    Junichi Furuta;Atsushi Kaneda;Yoshihiro Umebayashi;Fujio Otsuka

  • Epigenetic field for cancerization.

    Toshikazu Ushijima

  • Establishment of methylation-sensitive–representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors

    Toshikazu Ushijima;Keiichirou Morimura;Yoko Hosoya;Hideo Okonogi

  • Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment

    Naoko Kuzumaki;Daigo Ikegami;Rie Tamura;Nana Hareyama

  • RUNX3 Suppresses Gastric Epithelial Cell Growth by Inducing p21WAF1/Cip1 Expression in Cooperation with Transforming Growth Factor β-Activated SMAD

    Xin-Zi Chi;Jeung-Ook Yang;Kwang-Youl Lee;Kosei Ito

  • Accumulation of genetic and epigenetic alterations in normal cells and cancer risk.

    Hideyuki Takeshima;Toshikazu Ushijima

  • Identification of silencing of nine genes in human gastric cancers.

    Atsushi Kaneda;Michio Kaminishi;Kazuyoshi Yanagihara;Takashi Sugimura

  • Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas.

    Junichi Furuta;Yoshimasa Nobeyama;Yoshihiro Umebayashi;Fujio Otsuka

  • A chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2’-deoxycytidine treatment and oligonucleotide microarray

    Satoshi Yamashita;Kazuki Moriguchi;Yoshimi Tsujino;Masae Tatematsu

Frequent Co-Authors

Takashi Sugimura
Takashi Sugimura National Cancer Centre
Minako Nagao
Minako Nagao National Cancer Research Institute, UK
Masae Tatematsu
Masae Tatematsu Nagoya University
Minoru Narita
Minoru Narita Hoshi University
Michiko Narita
Michiko Narita Tokyo Medical University
Hitoshi Tsuda
Hitoshi Tsuda National Defense Medical College
Hitoshi Katai
Hitoshi Katai Juntendo University
Toshio Sofuni
Toshio Sofuni National Institutes of Health
Keiji Wakabayashi
Keiji Wakabayashi University of Shizuoka
Takuji Gotoda
Takuji Gotoda Nihon University

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