World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
60
Citations
13259
World Ranking
1960
National Ranking
975

Overview

Toshio Sofuni is affiliated with the National Institutes of Health in the United States. Their research spans multiple disciplines including Veterinary science, Engineering, and Biochemistry, Genetics and Molecular Biology.

The scientist has contributed to areas such as Animal testing and alternatives, 3D Printing in Biomedical Research, and Molecular Biology Techniques and Applications. These topics reflect a cross-disciplinary approach combining biological sciences with technological innovations.

The notable recent paper authored by Toshio Sofuni is titled "Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT)", published in 2020 in the journal Mutation Research/Genetic Toxicology and Environmental Mutagenesis. This paper has received 63 citations.

Frequent co-authors collaborating with Toshio Sofuni include:

  • Stefan Pfuhler
  • Jan van Benthem
  • Rodger Curren
  • Shareen H. Doak
  • Mária Dušinská

The scientist's publications have appeared predominantly in the venue Mutation Research/Genetic Toxicology and Environmental Mutagenesis.

Toshio Sofuni's work integrates experimental models and molecular biology techniques. The focus on in vitro 3D tissue models addresses advances in genotoxicity testing, providing alternatives to traditional animal testing methods.

Their involvement in biomedical engineering subfields and small animal veterinary studies indicates a broad scientific interest bridging engineering and biological applications.

Best Publications

  • Primary mutagenicity screening of food additives currently used in Japan

    M. Ishidate;T. Sofuni;K. Yoshikawa;M. Hayashi

  • The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides.

    Makoto Hayashi;Takeshi Morita;Yukio Kodama;Toshio Sofuni

  • Report from the in vitro micronucleus assay working group

    Micheline Kirsch-Volders;Toshio Sofuni;Marilyn Aardema;Silvio Albertini

  • An application of Acridine Orange fluorescent staining to the micronucleus test.

    M. Hayashi;T. Sofuni;M. Ishidate

  • Multiple pathways for SOS-induced mutagenesis in Escherichia coli: An overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA

    Su-Ryang Kim;Geneviéve Maenhaut-Michel;Masami Yamada;Yoshihiro Yamamoto

  • A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures

    M. Ishidate;M.C. Harnois;T. Sofuni

  • Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B) the summary report of the 6th collaborative study by CSGMT/JEMS MMS. Collaborative Study of the Micronucleus Group Test. Mammalian Mutagenicity Study Group.

    Takeshi Morita;Norihide Asano;Takumi Awogi;Yu F Sasaki

  • Report from the in vitro micronucleus assay working group

    M. Kirsch-Volders;T. Sofuni;M. Aardema;S. Albertini

  • A new transgenic mouse mutagenesis test system using Spi- and 6-thioguanine selections.

    T. Nohmi;M. Katoh;H. Suzuki;M. Matsui

  • Development of genotoxicity assay systems that use aquatic organisms

    M Hayashi;T Ueda;K Uyeno;K Wada

  • Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project

    Michael Fenech;Stefano Bonassi;Julie Turner;Cecilia Lando

  • Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals.

    M. Hayashi;M. Kishi;T. Sofuni;M. Ishidate

  • Specificity and sensitivity of Salmonella typhimurium YG1041 and YG1042 strains possessing elevated levels of both nitroreductase and acetyltransferase activity

    Yuji Hagiwara;Masahiko Watanabe;Yoshimitsu Oda;Toshio Sofuni

  • Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU).

    Taijiro Matsushima;Makoto Hayashi;Atsuko Matsuoka;Motoi Ishidate

  • Report from working group on in vitro tests for chromosomal aberrations.

    Sheila M. Galloway;Marilyn J. Aardema;Motoi Ishidate;James L. Ivett

  • ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact.

    Lutz Müller;Yasumoto Kikuchi;Gregory Probst;Leonard Schechtman

  • Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test.

    A. Matsuoka;N. Yamazaki;T. Suzuki;M. Hayashi

  • Evaluation of the mouse lymphoma tk assay (microwell method) as an alternative to the in vitro chromosomal aberration test

    Masamitsu Honma;Makoto Hayashi;Hiroyasu Shimada;Noriho Tanaka

  • Kinetics of micronucleus formation in relation to chromosomal aberrations in mouse bone marrow

    Makoto Hayashi;Toshio Sofuni;Motoi Ishidate

  • Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests: I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards

    D.J. Tweats;D. Blakey;R.H. Heflich;A. Jacobs

Frequent Co-Authors

Makoto Hayashi
Makoto Hayashi makoto international consulting
Takehiko Nohmi
Takehiko Nohmi Gifu University
Masahiko Watanabe
Masahiko Watanabe Hokkaido University
Takayoshi Suzuki
Takayoshi Suzuki Osaka University
Toshikazu Ushijima
Toshikazu Ushijima National Cancer Centre
Minako Nagao
Minako Nagao National Cancer Research Institute, UK
Hiroshi Suzuki
Hiroshi Suzuki Obihiro University of Agriculture and Veterinary Medicine
Keiji Wakabayashi
Keiji Wakabayashi University of Shizuoka
Takashi Sugimura
Takashi Sugimura National Cancer Centre
Micheline Kirsch-Volders
Micheline Kirsch-Volders Vrije Universiteit Brussel

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Interested in molecular biology but want to explore flexible study options or related fields? There are diverse online programs that can enhance your knowledge and open up unique career pathways in science and allied disciplines.

For those seeking a broader impact on community health and wellness, a human services bachelors degree online can complement a science background and prepare you for roles in outreach, support, or counseling. If you already have teaching experience and are looking for a new direction, learn how to transition from teacher to speech pathologist—a field offering excellent opportunities at the intersection of science, healthcare, and communication.

Those interested in how design and biology interact can consider an architecture online degree, exploring areas like bio-inspired design or sustainable structures. Strong analytical skills also play a vital role in biology. An online degree mathematics can boost your credentials for data-driven research, bioinformatics, or advanced lab work.

With so many online and interdisciplinary study options, students of molecular biology can expand their career possibilities and tailor their education to fit their unique goals.

Best Scientists Citing Toshio Sofuni

Trending Scientists