World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
8892
World Ranking
17651
National Ranking
7243

Overview

Marilyn J. Aardema is a researcher affiliated with Procter & Gamble in the United States, with a focus on toxicology and related biochemistry fields. Their work spans several areas within biochemistry, genetics, molecular biology, and environmental science.

Their research encompasses multiple subfields, including molecular biology, cancer research, health, toxicology and mutagenesis, small animals, and materials chemistry. Key topics addressed in their work include carcinogens and genotoxicity assessment, effects and risks of endocrine disrupting chemicals, animal testing and alternatives, nanoparticles synthesis and applications, microplastics and plastic pollution, genomics, phytochemicals and oxidative stress, as well as glutathione transferases and polymorphisms.

Marilyn J. Aardema has contributed to scientific publications in a variety of venues, notably:

  • Mutagenesis
  • Regulatory Toxicology and Pharmacology
  • Food and Chemical Toxicology
  • Critical Reviews in Toxicology
  • UNC Libraries

Their recent notable papers include:

  • A weight of evidence review of the genotoxicity of titanium dioxide (TiO2), 2022, Regulatory Toxicology and Pharmacology
  • Validation of the 3D reconstructed human skin micronucleus (RSMN) assay: an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays, 2020, Mutagenesis
  • A weight of evidence assessment of the genotoxic potential of 4-methylimidazole as a possible mode of action for the formation of lung tumors in exposed mice, 2020, Food and Chemical Toxicology
  • A review of mammalian in vivo genotoxicity of hexavalent chromium: implications for oral carcinogenicity risk assessment, 2021, Critical Reviews in Toxicology
  • Use of the EpiDermTM 3D reconstructed skin micronucleus assay for fragrance materials, 2021, Mutagenesis

Collaborations have been a part of Aardema's work, with frequent coauthors including Stefan Pfuhler, David Kirkland, Shambhu Roy, R. V. Battersby, and Carol Beevers.

Best Publications

  • Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: I. Sensitivity, specificity and relative predictivity

    David Kirkland;Marilyn Aardema;Leigh Henderson;Lutz Müller

  • Report from the in vitro micronucleus assay working group

    Micheline Kirsch-Volders;Toshio Sofuni;Marilyn Aardema;Silvio Albertini

  • Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies.

    Marilyn J. Aardema;James T. MacGregor

  • How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.

    David Kirkland;Stefan Pfuhler;David Tweats;Marilyn Aardema

  • Report from the in vitro micronucleus assay working group

    M. Kirsch-Volders;T. Sofuni;M. Aardema;S. Albertini

  • Report from working group on in vitro tests for chromosomal aberrations.

    Sheila M. Galloway;Marilyn J. Aardema;Motoi Ishidate;James L. Ivett

  • Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens II. Further analysis of mammalian cell results, relative predictivity and tumour profiles.

    David Kirkland;Marilyn Aardema;Lutz Müller;Hayashi Makoto

  • In vitro genotoxicity testing using the micronucleus assay in cell lines, human lymphocytes and 3D human skin models.

    Micheline Kirsch-Volders;Ilse Decordier;Azeddine Elhajouji;Gina Plas

  • SFTG international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study.

    Elisabeth Lorge;Veronique Thybaud;Marilyn J Aardema;Jo Oliver

  • Concepts of threshold in mutagenesis and carcinogenesis.

    Micheline Kirsch-Volders;Marilyn Aardema;Azeddine Elhajouji

  • Strategy for genotoxicity testing: hazard identification and risk assessment in relation to in vitro testing

    V. Thybaud;M. Aardema;J. Clements;K. Dearfield

  • Characterization of p53 in Chinese hamster cell lines CHO-K1, CHO-WBL, and CHL: Implications for genotoxicity testing.

    Ting Hu;Cathy M Miller;Gregg M Ridder;Marilyn J Aardema

  • The utility of DNA microarrays for characterizing genotoxicity.

    Ronald K Newton;Marilyn Aardema;Jiri Aubrecht

  • In vitro approaches to develop weight of evidence (WoE) and mode of action (MoA) discussions with positive in vitro genotoxicity results

    D. J. Kirkland;M. Aardema;N. Banduhn;P. Carmichael

  • Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm).

    Rodger D. Curren;Greg C. Mun;David P. Gibson;Marilyn J. Aardema

  • The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals

    R.A. LeBoeuf;G.A. Kerckaert;M.J. Aardema;D.P. Gibson

  • A review of the carcinogenic potential of glyphosate by four independent expert panels and comparison to the IARC assessment

    Gary M. Williams;Marilyn Aardema;John Acquavella;Sir Colin Berry

  • SFTG international collaborative study on in vitro micronucleus test III. Using CHO cells.

    Marilyn J. Aardema;Ronald D. Snyder;Carol Spicer;Katyayini Divi

  • Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins.

    Ting Hu;David P Gibson;Gregory J Carr;Suzanne M Torontali

  • Improvement of in vivo genotoxicity assessment: Combination of acute tests and integration into standard toxicity testing

    Andreas Rothfuss;Masamitu Honma;Andreas Czich;Marilyn J. Aardema

Frequent Co-Authors

David Kirkland
David Kirkland Covance (United States)
Micheline Kirsch-Volders
Micheline Kirsch-Volders Vrije Universiteit Brussel
Errol Zeiger
Errol Zeiger National Institutes of Health
James T. MacGregor
James T. MacGregor United States Food and Drug Administration
Michael Fenech
Michael Fenech University of South Australia
Toshio Sofuni
Toshio Sofuni National Institutes of Health
Makoto Hayashi
Makoto Hayashi makoto international consulting
Hannu Norppa
Hannu Norppa Finnish Institute of Occupational Health
Jordi Surrallés
Jordi Surrallés Autonomous University of Barcelona
Daniel A. Casciano
Daniel A. Casciano University of Arkansas at Little Rock

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Marilyn J. Aardema

Trending Scientists

Recently Published Articles