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Neuroscience

D-Index
48
Citations
11084
World Ranking
6131
National Ranking
494

Overview

Patricia C. Salinas is affiliated with University College London in the United Kingdom. Their research spans multiple areas in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these broader fields, Salinas has focused on several subfields including Molecular Biology, Physiology, Cellular and Molecular Neuroscience, Genetics, and Neurology.

The main research topics addressed in Salinas's work consist of:

  • Wnt/β-catenin signaling in development and cancer
  • Alzheimer's disease research and treatments
  • Genetics and Neurodevelopmental Disorders
  • Cancer-related gene regulation
  • Nuclear Receptors and Signaling
  • Neuroscience and Neuropharmacology Research
  • Neuroinflammation and Neurodegeneration Mechanisms

Salinas has published extensively, with notable contributions to key scientific venues. Frequent publication platforms include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Reportes científicos de la FACEN
  • Proceedings of the National Academy of Sciences
  • eLife
  • Journal of Medicinal Chemistry

Key recent papers authored by Salinas or featuring their collaboration are:

  • "Rational design of a conformation-specific antibody for the quantification of Aβ oligomers" (2020), Proceedings of the National Academy of Sciences
  • "Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo" (2020), Proceedings of the National Academy of Sciences
  • "Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters" (2022), Molecular Psychiatry
  • "A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease" (2023), Science Advances
  • "Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation" (2021), Frontiers in Molecular Neuroscience

Salinas has collaborated frequently with several researchers, including:

  • Núria Martín-Flores
  • Paul J. Whiting
  • Marina Podpolny
  • Faye McLeod
  • Ernest Palomer

Best Publications

  • Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling.

    Anita C Hall;Fiona R Lucas;Patricia C Salinas

  • WNTS in the vertebrate nervous system: from patterning to neuronal connectivity

    Lorenza Ciani;Patricia C. Salinas

  • Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development

    Silvana B Rosso;Daniel Sussman;Anthony Wynshaw-Boris;Patricia C Salinas

  • WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons

    Fiona R. Lucas;Patricia C. Salinas

  • Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium

    Fiona R. Lucas;Robert G. Goold;Phillip R. Gordon-Weeks;Patricia C. Salinas

  • Wnt signaling in neural circuit assembly.

    Patricia C. Salinas;Yimin Zou

  • Wnt signaling during synaptic development and plasticity

    Vivian Budnik;Patricia C Salinas

  • WNT signaling in the control of hair growth and structure.

    Sarah E. Millar;Karl Willert;Patricia C. Salinas;Patricia C. Salinas;Henk Roelink;Henk Roelink

  • A divergent canonical WNT-signaling pathway regulates microtubule dynamics: Dishevelled signals locally to stabilize microtubules

    Lorenza Ciani;Olga Y. Krylova;Matthew J. Smalley;Trevor C Dale

  • Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release

    Azlina Ahmad-Annuar;Lorenza Ciani;Iordanis Simeonidis;Judit Herreros

  • Wnt Signaling in the Vertebrate Central Nervous System: From Axon Guidance to Synaptic Function

    Patricia C. Salinas

  • Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea.

    Alain Dabdoub;Maura J. Donohue;Angela Brennan;Vladimir Wolf

  • Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca2+/Calmodulin-dependent protein kinase II

    Lorenza Ciani;Kieran A. Boyle;Ellen Dickins;Macarena Sahores

  • Isolation and Characterization of a Mouse Homolog of the Drosophila Segment Polarity Gene dishevelled

    Daniel J. Sussman;John Klingensmith;Patricia Salinas;Pamela S. Adams

  • Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.

    Ernest Palomer;Johanna Buechler;Patricia C. Salinas

  • The Secreted Wnt Antagonist Dickkopf-1 Is Required for Amyloid β-Mediated Synaptic Loss

    Silvia A Purro;Ellen M Dickins;Patricia C Salinas

  • WNT-3, expressed by motoneurons, regulates terminal arborization of neurotrophin-3-responsive spinal sensory neurons

    Olga Krylova;Judit Herreros;Karen E Cleverley;Elisabeth Ehler

  • Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli

    Silvia A. Purro;Lorenza Ciani;Monica Hoyos-Flight;Eleanna Stamatakou

  • Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons.

    Anita C. Hall;Angela Brennan;Robert G. Goold;Karen Cleverley

  • Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis

    Macarena Sahores;Alasdair Gibb;Patricia C. Salinas

  • Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin

    Juan P. Henriquez;Anna Webb;Matthew Bence;Heidi Bildsoe

Frequent Co-Authors

Jorge H. Crosa
Jorge H. Crosa Oregon Health & Science University
Michael Häusser
Michael Häusser University College London
Richard J. Rodenburg
Richard J. Rodenburg Radboud University
Philip L. Beales
Philip L. Beales University College London
Gregory S. Barsh
Gregory S. Barsh Stanford University
Anthony Wynshaw-Boris
Anthony Wynshaw-Boris Case Western Reserve University
Norbert Perrimon
Norbert Perrimon Harvard University
Neal G. Copeland
Neal G. Copeland The University of Texas MD Anderson Cancer Center
Juan L. Barja
Juan L. Barja University of Santiago de Compostela
Nancy A. Jenkins
Nancy A. Jenkins The University of Texas MD Anderson Cancer Center

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