2026 Nibaldo C. Inestrosa: Neuroscience Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Neuroscience	97	833	746	1	1	447	31013
Biology and Biochemistry	99	1601	1445	1	1	456	32466

Research.com Recognitions

2026 - Research.com Biology and Biochemistry in Chile Leader Award
2026 - Research.com Neuroscience in Chile Leader Award
2025 - Research.com Biology and Biochemistry in Chile Leader Award
2025 - Research.com Neuroscience in Chile Leader Award
2023 - Research.com Biology and Biochemistry in Chile Leader Award
2023 - Research.com Neuroscience in Chile Leader Award
2022 - Research.com Biology and Biochemistry in Chile Leader Award
2022 - Research.com Neuroscience in Chile Leader Award
1999 - Fellow of John Simon Guggenheim Memorial Foundation
1997 - Fellow, The World Academy of Sciences

Overview

Nibaldo C. Inestrosa is affiliated with the Pontificia Universidad Católica de Chile in Chile. The main fields of their research include Medicine and Biochemistry, Genetics and Molecular Biology. Their work focuses on several subfields such as Physiology, Cellular and Molecular Neuroscience, Complementary and Alternative Medicine, Molecular Biology, and Aging.

The scientist has contributed primarily to topics including Alzheimer's disease research and treatments, medicinal plants and neuroprotection, neuroscience and neuropharmacology research, genetics, aging, and longevity in model organisms, cholinesterase and neurodegenerative diseases, computational drug discovery methods, and mitochondrial function and pathology.

Nibaldo C. Inestrosa has published research in a variety of venues, including:

Biological Research
Journal of Medicinal Chemistry
Journal of Alzheimer s Disease
Neuroscience & Biobehavioral Reviews
International Journal of Molecular Sciences

Selected recent papers by the scientist include:

Inflammation context in Alzheimer's disease, a relationship intricate to define (2022) - Biological Research
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice (2020) - Journal of Medicinal Chemistry
Synaptic Mitochondria: An Early Target of Amyloid-β and Tau in Alzheimer's Disease (2021) - Journal of Alzheimer s Disease
The transcriptional landscape of Alzheimer's disease and its association with Wnt signaling pathway (2021) - Neuroscience & Biobehavioral Reviews
Lithium Enhances Hippocampal Glucose Metabolism in an In Vitro Mice Model of Alzheimer's Disease (2022) - International Journal of Molecular Sciences

Frequent co-authors collaborating with Nibaldo C. Inestrosa include Pedro Cisternas, Camila Gherardelli, Juan M. Zolezzi, Paulina Salazar, and Angie K. Torres.

Among the recognitions received by the scientist are the Fellow of John Simon Guggenheim Memorial Foundation awarded in 1999 and Fellow of The World Academy of Sciences awarded in 1997.

Best Publications

Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

Nibaldo C. Inestrosa;Alejandra Alvarez;Cristián A. Pérez;Ricardo D. Moreno

1297
Citations
Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid Cu-DEPENDENT CATALYTIC CONVERSION OF DOPAMINE, CHOLESTEROL, AND BIOLOGICAL REDUCING AGENTS TO NEUROTOXIC H2O2

Carlos Opazo;Xudong Huang;Robert A. Cherny;Robert D. Moir

780
Citations
Settlement of benthic marine invertebrates

SR Rodriguez;FP Ojeda;NC Inestrosa

771
Citations
Emerging roles of Wnts in the adult nervous system

Nibaldo C. Inestrosa;Ernest Arenas

756
Citations
A structural motif of acetylcholinesterase that promotes amyloid β-peptide fibril formation

G. V. De Ferrari;M. A. Canales;I. Shin;L. M. Weiner

524
Citations
The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer’s disease

Soledad Miranda;Carlos Opazo;Luis F Larrondo;Francisco J Muñoz

515
Citations
Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils

G V De Ferrari;M A Chacón;M I Barría;J L Garrido

449
Citations
Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils

Alejandra Alvarez;Rodrigo Alarcón;Carlos Opazo;Eliseo O. Campos

445
Citations
The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation.

Claudio Soto;Eduardo M. Castaño;Blas Frangione;Nibaldo C. Inestrosa

427
Citations
Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils.

Alejandra Alvarez;Carlos Opazo;Rodrigo Alarcón;Jorge Garrido

377
Citations
Wnt signaling function in Alzheimer's disease.

Giancarlo V. De Ferrari and;Nibaldo C. Inestrosa

375
Citations
Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease

E M Toledo;N C Inestrosa

360
Citations
Wnt signaling in the nervous system and in Alzheimer's disease

Nibaldo C. Inestrosa;Lorena Varela-Nallar

355
Citations
Peroxisome Proliferator-activated Receptor γ Up-regulates the Bcl-2 Anti-apoptotic Protein in Neurons and Induces Mitochondrial Stabilization and Protection against Oxidative Stress and Apoptosis

Karen Fuenzalida;Rodrigo Quintanilla;Patricio Ramos;Daniela Piderit

350
Citations
WNT signaling in neuronal maturation and synaptogenesis.

Silvana Beatriz Rosso;Nibaldo C. Inestrosa

341
Citations
Amyloid–cholinesterase interactions

Nibaldo C. Inestrosa;Margarita C. Dinamarca;Alejandra Alvarez

332
Citations
Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons.

Alejandra R Alvarez;Juan A Godoy;Karin Mullendorff;Gonzalo H Olivares

306
Citations
Wnt signaling in neuroprotection and stem cell differentiation.

Enrique M. Toledo;Marcela Colombres;Nibaldo C. Inestrosa

295
Citations
Fatty acid oxidation by human liver peroxisomes

Miguel Bronfman;Nibaldo C. Inestrosa;Federico Leighton

282
Citations
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

Amado Carreras-Sureda;Fabián Jaña;Hery Urra;Sylvere Durand;Sylvere Durand

260
Citations
Intracellular Amyloid Formation in Muscle Cells of Aβ-Transgenic Caenorhabditis Elegans: Determinants and Physiological Role in Copper Detoxification

Alicia N Minniti;Daniela L Rebolledo;Paula M Grez;Ricardo Fadic

44
Citations