D-Index & Metrics Best Publications
Neuroscience
Chile
2023
Biology and Biochemistry
Chile
2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Neuroscience D-index 85 Citations 22,469 362 World Ranking 761 National Ranking 1
Biology and Biochemistry D-index 91 Citations 27,198 426 World Ranking 1505 National Ranking 1

Research.com Recognitions

Awards & Achievements

2023 - Research.com Biology and Biochemistry in Chile Leader Award

2023 - Research.com Neuroscience in Chile Leader Award

2022 - Research.com Biology and Biochemistry in Chile Leader Award

2022 - Research.com Neuroscience in Chile Leader Award

1999 - Fellow of John Simon Guggenheim Memorial Foundation

1997 - Fellow, The World Academy of Sciences

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Biochemistry

Nibaldo C. Inestrosa mostly deals with Neuroscience, Wnt signaling pathway, Cell biology, Biochemistry and Acetylcholinesterase. His Neuroscience research is multidisciplinary, incorporating perspectives in Alzheimer's disease, Disease and Synaptic plasticity. Nibaldo C. Inestrosa has researched Wnt signaling pathway in several fields, including Neurotoxicity, Neurodegeneration and Neuroprotection.

His studies in Cell biology integrate themes in fields like Hippocampal formation, Endocrinology, Internal medicine, Neurotransmission and Synapse. His Biochemistry research focuses on Amyloid and how it connects with P3 peptide, Protein structure, Fibril and Ligand. The Acetylcholinesterase study combines topics in areas such as Cell culture, Basal lamina, Peptide sequence, Intracellular and Pharmacology.

His most cited work include:

  • Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme (847 citations)
  • Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid Cu-DEPENDENT CATALYTIC CONVERSION OF DOPAMINE, CHOLESTEROL, AND BIOLOGICAL REDUCING AGENTS TO NEUROTOXIC H2O2 (512 citations)
  • Emerging roles of Wnts in the adult nervous system (467 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Cell biology, Wnt signaling pathway, Neuroscience, Biochemistry and Acetylcholinesterase. His study in Cell biology is interdisciplinary in nature, drawing from both Hippocampal formation, Synapse, Postsynaptic potential and Neuroprotection. His Wnt signaling pathway study incorporates themes from Endocrinology and Internal medicine.

The study incorporates disciplines such as Synaptic plasticity, Disease, Neurodegeneration and Neurotransmission in addition to Neuroscience. His studies deal with areas such as Amyloid precursor protein and Amyloid as well as Biochemistry. He interconnects Basal lamina, Neuromuscular junction, Cholinergic and Senile plaques in the investigation of issues within Acetylcholinesterase.

He most often published in these fields:

  • Cell biology (62.17%)
  • Wnt signaling pathway (58.24%)
  • Neuroscience (50.94%)

What were the highlights of his more recent work (between 2016-2021)?

  • Cell biology (62.17%)
  • Wnt signaling pathway (58.24%)
  • Neuroscience (50.94%)

In recent papers he was focusing on the following fields of study:

Nibaldo C. Inestrosa spends much of his time researching Cell biology, Wnt signaling pathway, Neuroscience, Neuroprotection and Hippocampal formation. His Cell biology study integrates concerns from other disciplines, such as Synaptic plasticity, Synapse, Postsynaptic potential and Neurotransmission. His Wnt signaling pathway research includes elements of Neurodegeneration and Disease.

His study in Neuroscience is interdisciplinary in nature, drawing from both Identification and Social isolation. In his study, Endoplasmic reticulum, Neurotoxicity and Mitochondrial permeability transition pore is strongly linked to Mitochondrion, which falls under the umbrella field of Neuroprotection. His research in Hippocampal formation intersects with topics in Genetically modified mouse, Transgene, Hippocampus and Toxicity.

Between 2016 and 2021, his most popular works were:

  • Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics (65 citations)
  • Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease (48 citations)
  • Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice (47 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Internal medicine

His primary scientific interests are in Wnt signaling pathway, Cell biology, Neuroprotection, Neurodegeneration and Disease. His work deals with themes such as Carbohydrate metabolism, Central nervous system, Neuroscience and Function, which intersect with Wnt signaling pathway. The various areas that Nibaldo C. Inestrosa examines in his Cell biology study include Synaptic plasticity, Postsynaptic potential, Neurotransmission and Amyloid precursor protein.

His Neuroprotection study integrates concerns from other disciplines, such as Cell growth, PORCN, Hippocampal formation, Alzheimer's disease and Hippocampus. His work investigates the relationship between Hippocampus and topics such as Cathepsin D that intersect with problems in Internal medicine and Endocrinology. His research in Neurodegeneration focuses on subjects like Neurotoxicity, which are connected to Bioinformatics, Parkinson's disease and Paraquat.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

Nibaldo C. Inestrosa;Alejandra Alvarez;Cristián A. Pérez;Ricardo D. Moreno.
Neuron (1996)

1196 Citations

Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid Cu-DEPENDENT CATALYTIC CONVERSION OF DOPAMINE, CHOLESTEROL, AND BIOLOGICAL REDUCING AGENTS TO NEUROTOXIC H2O2

Carlos Opazo;Xudong Huang;Robert A. Cherny;Robert D. Moir.
Journal of Biological Chemistry (2002)

747 Citations

Emerging roles of Wnts in the adult nervous system

Nibaldo C. Inestrosa;Ernest Arenas.
Nature Reviews Neuroscience (2010)

683 Citations

Settlement of benthic marine invertebrates

SR Rodriguez;FP Ojeda;NC Inestrosa.
Marine Ecology Progress Series (1993)

663 Citations

The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer’s disease

Soledad Miranda;Carlos Opazo;Luis F Larrondo;Francisco J Muñoz.
Progress in Neurobiology (2000)

484 Citations

A structural motif of acetylcholinesterase that promotes amyloid β-peptide fibril formation

G. V. De Ferrari;M. A. Canales;I. Shin;L. M. Weiner.
Biochemistry (2001)

473 Citations

The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation.

Claudio Soto;Eduardo M. Castaño;Blas Frangione;Nibaldo C. Inestrosa.
Journal of Biological Chemistry (1995)

451 Citations

Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils

G V De Ferrari;M A Chacón;M I Barría;J L Garrido.
Molecular Psychiatry (2003)

419 Citations

Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils

Alejandra Alvarez;Rodrigo Alarcón;Carlos Opazo;Eliseo O. Campos.
The Journal of Neuroscience (1998)

400 Citations

Wnt signaling function in Alzheimer's disease.

Giancarlo V. De Ferrari and;Nibaldo C. Inestrosa.
Brain Research Reviews (2000)

362 Citations

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