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Biology and Biochemistry
Chile
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
8870
World Ranking
9421
National Ranking
8

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Chile Leader Award
  • 2025 - Research.com Biology and Biochemistry in Chile Leader Award

Overview

Enrique Brandan is affiliated with San Sebastián University in Chile and has contributed extensively to research in biochemistry, genetics, and molecular biology, with additional work in medicine. Their research primarily centers on molecular biology, cell biology, and genetics, with notable focus areas including muscle physiology and disorders, Hippo pathway signaling and YAP/TAZ, and connective tissue growth factor research.

Their work covers several subfields such as cellular and molecular neuroscience and biochemistry. Brandan's research topics include mesenchymal stem cell research, muscle metabolism and nutrition, hereditary neurological disorders, as well as lipid metabolism and biosynthesis.

Enrique Brandan has published research in a variety of scientific journals, most frequently in:

  • International Journal of Molecular Sciences
  • Matrix Biology
  • Journal of Cell Communication and Signaling
  • Cellular Signalling
  • Journal of Cell Science

Their recent key publications include:

  • "PDGF-PDGFR network differentially regulates the fate, migration, proliferation, and cell cycle progression of myogenic cells," 2021, Cellular Signalling
  • "HIF-hypoxia signaling in skeletal muscle physiology and fibrosis," 2020, Journal of Cell Communication and Signaling
  • "TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα+ fibroblasts," 2020, Journal of Cell Science
  • "Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle," 2020, International Journal of Molecular Sciences
  • "Driving fibrosis in neuromuscular diseases: Role and regulation of Connective tissue growth factor (CCN2/CTGF)," 2021, Matrix Biology Plus

Frequent co-authors collaborating with Brandan include:

  • Adriana Córdova-Casanova
  • Felipe S. Gallardo
  • Juan Carlos Casar
  • Meilyn Cruz-Soca
  • Alexia Bock-Pereda

Best Publications

  • Decorin Core Protein Fragment Leu155-Val260 Interacts with TGF-β but Does Not Compete for Decorin Binding to Type I Collagen

    Elke Schönherr;Marion Broszat;Enrique Brandan;Peter Bruckner

  • ECM is required for skeletal muscle differentiation independently of muscle regulatory factor expression

    Nelson Osses;Enrique Brandan

  • Anchorage of collagen-tailed acetylcholinesterase to the extracellular matrix is mediated by heparan sulfate proteoglycans.

    E Brandan;M Maldonado;J Garrido;N C Inestrosa

  • Mice long-term high-fat diet feeding recapitulates human cardiovascular alterations: an animal model to study the early phases of diabetic cardiomyopathy.

    Sebastián D. Calligaris;Manuel Lecanda;Felipe Solis;Marcelo Ezquer

  • Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling

    María José Acuña;Patrizia Pessina;Hugo Olguin;Daniel Cabrera

  • Extracellular proteoglycans modify TGF-β bio-availability attenuating its signaling during skeletal muscle differentiation

    Rebeca Droguett;Claudio Cabello-Verrugio;Cecilia Riquelme;Enrique Brandan

  • CTGF inhibits BMP-7 signaling in diabetic nephropathy.

    Tri Q. Nguyen;Peggy Roestenberg;Frans A. van Nieuwenhoven;Niels Bovenschen

  • Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation

    Juan Carlos Casar;Claudio Cabello-Verrugio;Hugo Olguin;Rebeca Aldunate

  • Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis

    Osvaldo Contreras;Daniela L. Rebolledo;Juan Esteban Oyarzún;Hugo C. Olguín

  • Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy

    Maria Gabriela Morales;Jaime Gutierrez;Claudio Cabello-Verrugio;Daniel Cabrera

  • A Novel Modulatory Mechanism of Transforming Growth Factor-β Signaling through Decorin and LRP-1

    Claudio Cabello-Verrugio;Enrique Brandan

  • Wnt signaling in skeletal muscle dynamics: myogenesis, neuromuscular synapse and fibrosis.

    Pedro Cisternas;Juan P. Henriquez;Enrique Brandan;Nibaldo C. Inestrosa

  • Extracellular matrix is required for skeletal muscle differentiation but not myogenin expression

    Francisco Melo;David J. Carey;Enrique Brandan

  • Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation

    Cecilia Vial;Lidia Miriam Zúñiga;Claudio Cabello-Verrugio;Pablo Cañón

  • Biglycan is a new extracellular component of the Chordin–BMP4 signaling pathway

    Mauricio Moreno;Rosana Muñoz;Francisco Aroca;Mariana Labarca

  • Antisense inhibition of decorin expression in myoblasts decreases cell responsiveness to transforming growth factor beta and accelerates skeletal muscle differentiation.

    Cecilia Riquelme;Juan Larraı́n;Elke Schönherr;Juan Pablo Henriquez

  • A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation.

    Jaime Gutiérrez;Enrique Brandan

  • Decorin Interacts with Connective Tissue Growth Factor (CTGF)/CCN2 by LRR12 Inhibiting Its Biological Activity

    Cecilia Vial;Jaime Gutiérrez;Cristian Santander;Daniel Cabrera

  • Transient up-regulation of biglycan during skeletal muscle regeneration: delayed fiber growth along with decorin increase in biglycan-deficient mice.

    Juan Carlos Casar;Beth A McKechnie;Justin R Fallon;Marian F Young

  • Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy.

    Enrique Brandan;Claudio Cabello-Verrugio;Cecilia Vial

Frequent Co-Authors

Nibaldo C. Inestrosa
Nibaldo C. Inestrosa Pontificia Universidad Católica de Chile
Robson A.S. Santos
Robson A.S. Santos Universidade Federal de Minas Gerais
David J. Carey
David J. Carey Geisinger Health System
Fabio M.V. Rossi
Fabio M.V. Rossi University of British Columbia
Roel Goldschmeding
Roel Goldschmeding Utrecht University
Michael Bader
Michael Bader Max Delbrück Center for Molecular Medicine
Pura Muñoz-Cánoves
Pura Muñoz-Cánoves Pompeu Fabra University
Hans Kresse
Hans Kresse University of Münster
Carlos B. Hirschberg
Carlos B. Hirschberg Boston University
Juan C. Sáez
Juan C. Sáez University of Valparaíso

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