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Lena Kjellén

Lena Kjellén

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
14859
World Ranking
11841
National Ranking
174

Overview

Lena Kjellén is a scientist affiliated with Uppsala University in Sweden, specializing in biochemistry, genetics, and molecular biology. Their research primarily focuses on the study of proteoglycans and glycosaminoglycans, with a particular interest in glycosylation processes and mast cell biology.

Their recent published works include the following papers:

  • Landscape of mast cell populations across organs in mice and humans, 2023, The Journal of Experimental Medicine
  • Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate, 2020, Matrix Biology
  • A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation, 2022, Glycobiology
  • Heparin and heparan sulfate-The essence of sequence, 2024, Proteoglycan Research
  • Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development, 2022, PLoS Genetics

The scientist has collaborated with several frequent coauthors, including Tabea Dierker, M. Tauber, Lilian Basso, J.-C. Martin, and Luciana Bostan. Their work spans multiple respected journals with repeated publications in The Journal of Experimental Medicine and Matrix Biology, as well as contributions to Proteoglycan Research, Glycobiology, and PLoS Genetics.

Kjellén's research covers several subfields within biochemistry and molecular biology:

  • Cell Biology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy
  • Organic Chemistry

The main scientific topics addressed in their work include:

  • Proteoglycans and glycosaminoglycans research
  • Glycosylation and glycoproteins research
  • Mast cells and histamine
  • Allergic rhinitis and sensitization
  • Fibroblast growth factor research
  • Hippo pathway signaling and YAP/TAZ
  • Carbohydrate chemistry and synthesis

Best Publications

  • Proteoglycans: structures and interactions.

    Lena Kjellén;Ulf Lindahl

  • Regulated diversity of heparan sulfate.

    Ulf Lindahl;Marion Kusche-Gullberg;Lena Kjellén

  • Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme

    Erik Forsberg;Gunnar Pejler;Maria Ringvall;Carolina Lunderius

  • More to “heparin” than anticoagulation

    Ulf Lindahl;Kerstin Lidholt;Dorothe Spillmann;Lena Kjellén

  • Sulfotransferases in glycosaminoglycan biosynthesis.

    Marion Kusche-Gullberg;Lena Kjellén

  • Heparan sulfate biosynthesis: regulation and variability.

    Johan Kreuger;Lena Kjellén

  • Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis.

    Lars Jakobsson;Johan Kreuger;Katarina Holmborn;Lars Lundin

  • Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1

    Maria Ringvall;Johan Ledin;Katarina Holmborn;Toin van Kuppevelt

  • Heparan Sulfate Structure in Mice with Genetically Modified Heparan Sulfate Production

    Johan Ledin;William Staatz;Jin Ping Li;Martin Götte

  • The viability of cells grown or centrifuged in a new density gradient medium, Percoll(TM).

    Håkan Pertoft;Kristofer Rubin;Lena Kjellén;Torvard C. Laurent

  • Cell-surface heparan sulfate. Mechanisms of proteoglycan-cell association.

    L Kjellén;A Oldberg;M Höök

  • Heparan sulfate: lessons from knockout mice

    Erik Forsberg;Lena Kjellén

  • Contribution of EXT1, EXT2, and EXTL3 to Heparan Sulfate Chain Elongation

    Marta Busse;Almir Feta;Jenny Presto;Maria Wilén

  • Cell-surface heparan sulfate. Isolation and characterization of a proteoglycan from rat liver membranes.

    A. Oldberg;L. Kjellen;Magnus Hook

  • Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

    Jenny Presto;Maria Thuveson;Pernilla Carlsson;Marta Busse

  • Pathophysiology of heparan sulphate: many diseases, few drugs

    Ulf Lindahl;Lena Kjellén

  • Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development

    Alexandra Abramsson;Sindhulakshmi Kurup;Marta Busse;Shuhei Yamada

  • cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin.

    I. Eriksson;D. Sandbäck;B. Ek;U. Lindahl

  • Relationship of heparan sulfate proteoglycans to the cytoskeleton and extracellular matrix of cultured fibroblasts.

    A. Woods;Magnus Hook;L. Kjellen;C. G. Smith

  • Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes.

    Kay Grobe;Johan Ledin;Maria Ringvall;Katarina Holmborn

Frequent Co-Authors

Ulf Lindahl
Ulf Lindahl Uppsala University
Gunnar Pejler
Gunnar Pejler Uppsala University
Dorothe Spillmann
Dorothe Spillmann Uppsala University
Jin-Ping Li
Jin-Ping Li Uppsala University
Magnus Höök
Magnus Höök Texas A&M Health Science Center
Magnus Åbrink
Magnus Åbrink Swedish University of Agricultural Sciences
Åke Oldberg
Åke Oldberg Lund University
Lena Claesson-Welsh
Lena Claesson-Welsh Uppsala University
Lars Hellman
Lars Hellman Uppsala University
Kristofer Rubin
Kristofer Rubin Uppsala University

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