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Chemistry

D-Index
142
Citations
80170
World Ranking
189
National Ranking
90

Research.com Recognitions

  • 2014 - Fellow, National Academy of Inventors
  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Robert J. Linhardt was affiliated with Rensselaer Polytechnic Institute in the United States. Their research career encompassed a focus on biochemistry, genetics, molecular biology, and medicine, contributing extensively to these fields through numerous publications and collaborations.

Their work primarily involved molecular biology, cell biology, organic chemistry, epidemiology, and infectious diseases. The research topics Linhardt engaged with included:

  • Proteoglycans and glycosaminoglycans research
  • Glycosylation and glycoproteins research
  • Carbohydrate chemistry and synthesis
  • Polysaccharides and plant cell walls
  • Seaweed-derived bioactive compounds
  • Heparin-induced thrombocytopenia and thrombosis
  • Electrospun nanofibers in biomedical applications

The notable papers associated with Linhardt's research include:

  • "Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro," 2020, published in Cell Discovery
  • "Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions," 2020, published in Antiviral Research
  • "Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review," 2020, published in International Journal of Biological Macromolecules
  • "Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives," 2020, published in Journal of Virology
  • "Porphyrin-based compounds and their applications in materials and medicine," 2021, published in Dyes and Pigments

Throughout their career, Linhardt collaborated prominently with several researchers, including:

  • Fuming Zhang
  • Ke Xia
  • Jonathan S. Dordick
  • Jian Liu
  • Yuefan Song

Linhardt's research was published frequently in various venues, with a significant number of papers appearing in:

  • UNC Libraries
  • Carbohydrate Polymers
  • International Journal of Biological Macromolecules
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Molecular Biosciences

Over their scientific career, Linhardt received recognition such as being named a Fellow of the National Academy of Inventors in 2014 and a Fellow of the American Association for the Advancement of Science (AAAS) in 2009.

Best Publications

  • Heparin-protein interactions

    Ishan Capila;Robert J. Linhardt

  • Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

    Joseph Schlessinger;Alexander N. Plotnikov;Omar A. Ibrahimi;Anna V. Eliseenkova

  • Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate

    Yaping Chen;Terry Maguire;Ronald E. Hileman;Jonathan R. Fromm

  • Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis

    Sang Hyun Lee;Thomas V. Doherty;Robert J. Linhardt;Jonathan S. Dordick

  • Heparin structure and interactions with basic fibroblast growth factor.

    S. Faham;R. E. Hileman;J. R. Fromm;R. J. Linhardt

  • Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone

    Judah Folkman;Robert Langer;Robert J. Linhardt;Christian Haudenschild

  • Glycosaminoglycan‐protein interactions: definition of consensus sites in glycosaminoglycan binding proteins

    Ronald E. Hileman;Jonathan R. Fromm;John M. Weiler;Robert J. Linhardt

  • Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation

    RM Nelson;O Cecconi;WG Roberts;A Aruffo

  • Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events.

    Marco Guerrini;Daniela Beccati;Zachary Shriver;Annamaria Naggi

  • Cellular Binding of Hepatitis C Virus Envelope Glycoprotein E2 Requires Cell Surface Heparan Sulfate

    Heidi Barth;Christiane Schäfer;Mohammed I. Adah;Fuming Zhang

  • Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

    Regina Goetz;Andrew Beenken;Omar A. Ibrahimi;Juliya Kalinina

  • 2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity.

    Robert John Linhardt

  • Polysaccharides and phytochemicals: a natural reservoir for the green synthesis of gold and silver nanoparticles

    Y. Park;Y.N. Hong;A. Weyers;Y.S. Kim

  • RECENT ADVANCES IN STEREOSELECTIVE C-GLYCOSIDE SYNTHESIS

    Yuguo Du;Robert J. Linhardt;Iontcho R. Vlahov

  • Bioerodible polyanhydrides for controlled drug delivery

    Robert S. Langer;Howard Rosen;Robert J. Linhardt;Kam Leong

  • Lessons learned from the contamination of heparin

    Haiying Liu;Zhenqing Zhang;Robert J. Linhardt

  • Room Temperature Ionic Liquids as Emerging Solvents for the Pretreatment of Lignocellulosic Biomass

    Mauricio Mora-Pale;Luciana Meli;Thomas V. Doherty;Robert J. Linhardt

  • Electrospinning: A novel nano-encapsulation approach for bioactive compounds

    Peng Wen;Min-Hua Zong;Robert J. Linhardt;Kun Feng

  • Polysaccharide lyases

    R. J. Linhardt;P. M. Galliher;C. L. Cooney

  • Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents.

    A Koenig;K Norgard-Sumnicht;R Linhardt;A Varki

  • Green solvents in carbohydrate chemistry: from raw materials to fine chemicals.

    Angeles Farrán;Chao Cai;Manuel Sandoval;Yongmei Xu

Frequent Co-Authors

Fuming Zhang
Fuming Zhang Rensselaer Polytechnic Institute
Jonathan S. Dordick
Jonathan S. Dordick Rensselaer Polytechnic Institute
Toshihiko Toida
Toshihiko Toida Chiba University
Mattheos A. G. Koffas
Mattheos A. G. Koffas Rensselaer Polytechnic Institute
Shiguo Chen
Shiguo Chen Zhejiang University
Yeong Shik Kim
Yeong Shik Kim Seoul National University
Xingqian Ye
Xingqian Ye Zhejiang University
I. Jonathan Amster
I. Jonathan Amster University of Georgia
Jawed Fareed
Jawed Fareed Loyola University Chicago

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