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Toin H. van Kuppevelt

Toin H. van Kuppevelt

D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
19433
World Ranking
4824
National Ranking
112

Overview

Toin H. van Kuppevelt is affiliated with Radboud University in the Netherlands. Their research focuses primarily on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with particular expertise in Cell Biology, Molecular Biology, Genetics, Nephrology, and Biomaterials. The scientist's work covers a range of topics including proteoglycans and glycosaminoglycans research, wound healing and treatments, neonatal respiratory health research, connective tissue disorders, platelet disorders and treatments, fibroblast growth factor research, and peptidase inhibition and analysis.

Van Kuppevelt has contributed to multiple recent publications spanning various biomedical research areas. Among these are:

  • Evaluation and Refinement of Sample Preparation Methods for Extracellular Matrix Proteome Coverage, 2021, Molecular & Cellular Proteomics
  • Hypoxic Induction of Exosome Uptake through Proteoglycan-Dependent Endocytosis Fuels the Lipid Droplet Phenotype in Glioma, 2020, Molecular Cancer Research
  • The role of MMP-14 in ovarian cancer: a systematic review, 2021, Journal of Ovarian Research
  • Oncolytic Virus Therapy with HSV-1 for Hematological Malignancies, 2020, Molecular Therapy
  • Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema, 2021, American Journal of Physiology-Lung Cellular and Molecular Physiology

The scientist collaborates frequently with several researchers, including Willeke F. Daamen, Elly M. M. Versteeg, Danique J. Hof, Roman Krymchenko, and Nancy Avila-Martinez. These collaborations have resulted in multiple co-authored publications across related research areas.

Van Kuppevelt's work is published in various scientific venues, with multiple contributions to journals such as Frontiers in Immunology, Nature Communications, Glycobiology, Molecular & Cellular Proteomics, and Advanced Healthcare Materials. These outlets reflect the interdisciplinary nature of their research spanning immunology, molecular biology, and material sciences relevant to health and disease.

The scientist's research topics include a heavy emphasis on proteoglycans and glycosaminoglycans, which are critical components of extracellular matrix biology. Their exploration into wound healing and connective tissue disorders indicates a focus on tissue repair mechanisms and biomolecular factors influencing regenerative processes. Contributions to neonatal respiratory health research and platelet disorder studies broaden the biomedical impact of their work, further supported by investigations into growth factors and peptidase activities linked to cellular regulation and pathology.

Best Publications

  • Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

    Helena C. Christianson;Katrin J. Svensson;Toin H. van Kuppevelt;Jin-Ping Li

  • Cellular Binding of Hepatitis C Virus Envelope Glycoprotein E2 Requires Cell Surface Heparan Sulfate

    Heidi Barth;Christiane Schäfer;Mohammed I. Adah;Fuming Zhang

  • Increased angiogenesis and blood vessel maturation in acellular collagen-heparin scaffolds containing both FGF2 and VEGF.

    Suzan T.M. Nillesen;Paul J. Geutjes;Ronnie Wismans;Joost Schalkwijk

  • Generation and Application of Type-specific Anti-Heparan Sulfate Antibodies Using Phage Display Technology FURTHER EVIDENCE FOR HEPARAN SULFATE HETEROGENEITY IN THE KIDNEY

    A.H.M.S.M. van Kuppevelt;M.A.B.A. Dennissen;W.J.W. van Venrooij;R.M.A. Hoet

  • Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1

    Maria Ringvall;Johan Ledin;Katarina Holmborn;Toin van Kuppevelt

  • The performance of human dental pulp stem cells on different three-dimensional scaffold materials.

    Weibo Zhang;X. Frank Walboomers;Toin H. van Kuppevelt;Willeke F. Daamen

  • Linkage of chondroitin-sulfate to type I collagen scaffolds stimulates the bioactivity of seeded chondrocytes in vitro.

    Job L.C van Susante;Jeroen Pieper;Pieter Buma;Toin H van Kuppevelt

  • Chondroitin 6-sulphate synthesis is up-regulated in injured CNS, induced by injury-related cytokines and enhanced in axon-growth inhibitory glia.

    Francesca Properzi;Daniela Carulli;Richard A Asher;Elizabeth Muir

  • Large, tissue-regulated domain diversity of heparan sulfates demonstrated by phage display antibodies.

    Michel A.B.A. Dennissen;Guido J. Jenniskens;Martijn Pieffers;Elly M.M. Versteeg

  • Parietal Epithelial Cells Participate in the Formation of Sclerotic Lesions in Focal Segmental Glomerulosclerosis

    Bart Smeets;Christoph Kuppe;Eva Maria Sicking;Astrid Fuss

  • Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum

    Theo G.M.F. Gorgels;Xiaofeng Hu;George L. Scheffer;Allard C. van der Wal

  • Cross-linked type I and type II collagenous matrices for the repair of full-thickness articular cartilage defects--a study in rabbits.

    Pieter Buma;Jeroen S. Pieper;Tony van Tienen;Job L.C. van Susante

  • Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

    Natali Gil;Rachel Goldberg;Tzahi Neuman;Marjolein Garsen

  • Preferential uptake of L- versus D-amino acid cell-penetrating peptides in a cell type-dependent manner

    Wouter P.R. Verdurmen;Petra H. Bovee-Geurts;Parvesh Wadhwani;Anne S. Ulrich

  • Tissue engineering of blood vessels: characterization of smooth-muscle cells for culturing on collagen-and-elastin-based scaffolds.

    Paula Buijtenhuijs;Laura Buttafoco;Andre A. Poot;Willeke F. Daamen

  • Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate

    Martha L Escobar Galvis;Juan Jia;Xiao Zhang;Nadja Jastrebova

  • Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity

    William C. Lamanna;Rebecca J. Baldwin;Michael Padva;Ina Kalus

  • Heparan sulfate heterogeneity in skeletal muscle basal lamina: demonstration by phage display-derived antibodies

    Guido J. Jenniskens;Arie Oosterhof;Ricardo Brandwijk;Jacques H. Veerkamp

  • Antibody GD3G7 Selected against Embryonic Glycosaminoglycans Defines Chondroitin Sulfate-E Domains Highly Up-Regulated in Ovarian Cancer and Involved in Vascular Endothelial Growth Factor Binding

    Gerdy B. ten Dam;Els M.A. van de Westerlo;Anurag Purushothaman;Radu V. Stan

  • Heparan sulfate proteoglycans in glomerular inflammation

    Angelique L.W.M.M. Rops;Johan van der Vlag;Joost F.M. Lensen;Tessa J.M. Wijnhoven

Frequent Co-Authors

Johan van der Vlag
Johan van der Vlag Radboud University
Jacques H. Veerkamp
Jacques H. Veerkamp Radboud University
Leon F.A.G. Massuger
Leon F.A.G. Massuger Radboud University
Lambert P. van den Heuvel
Lambert P. van den Heuvel Radboud University
Kazuyuki Sugahara
Kazuyuki Sugahara Hokkaido University
Jin-Ping Li
Jin-Ping Li Uppsala University
Mattias Belting
Mattias Belting Lund University
Dorothe Spillmann
Dorothe Spillmann Uppsala University
Joost Schalkwijk
Joost Schalkwijk Radboud University
Ulf Lindahl
Ulf Lindahl Uppsala University

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