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Biology and Biochemistry

D-Index
53
Citations
11118
World Ranking
16088
National Ranking
6668

Overview

Maxwell P. Lee is affiliated with the National Institutes of Health in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a significant focus on topics related to cancer genomics, immunotherapy, and molecular mechanisms in oncology.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of study highlight a concentration in:

  • Molecular Biology
  • Oncology
  • Immunology
  • Cancer Research
  • Pulmonary and Respiratory Medicine

Maxwell P. Lee's research covers several key topics, including:

  • Cancer Genomics and Diagnostics
  • Cancer Immunotherapy and Biomarkers
  • Single-cell and Spatial Transcriptomics
  • Immune Cells in Cancer
  • Immunotherapy and Immune Responses
  • RNA Modifications and Cancer
  • RNA Research and Splicing

Recent publications from Maxwell P. Lee demonstrate involvement in diverse investigative areas. Some of the notable papers include:

  • "Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment" (2021, Cell)
  • "Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy" (2020, Nature Medicine)
  • "Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis" (2020, Nature Communications)
  • "Integrated analysis of genome-wide miRNAs and targeted gene expression in esophageal squamous cell carcinoma (ESCC) and relation to prognosis" (2020, BMC Cancer)
  • "Apoptosis-induced nuclear expulsion in tumor cells drives S100a4-mediated metastatic outgrowth through the RAGE pathway" (2023, Nature Cancer)

Publications by Maxwell P. Lee have appeared frequently in the following journals and venues:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature Medicine
  • BMC Cancer

Collaborations form an important part of Maxwell P. Lee's research output. Frequent co-authors include:

  • Howard H. Yang
  • Eva Pérez-Guijarro
  • Glenn Merlino
  • Huaitian Liu
  • Chi-Ping Day

Best Publications

  • Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

    Takuro Nakamura;David A. Largaespada;Maxwell P. Lee;Laura A. Johnson

  • Allelic Variation in Gene Expression Is Common in the Human Genome

    H. Shuen Lo;Zhining Wang;Ying Hu;Howard H. Yang

  • A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma

    Christian C. Abnet;Neal D. Freedman;Nan Hu;Zhaoming Wang;Zhaoming Wang

  • Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith–Wiedemann syndrome and is independent of insulin-like growth factor II imprinting

    Maxwell P. Lee;Michael R. DeBaun;Kohzoh Mitsuya;Heidi L. Galonek

  • Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements.

    Maxwell P. Lee;Ren-JuHu Hu;Laura A. Johnson;Andrew P. Feinberg

  • Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects.

    Michael R. DeBaun;Michael R. DeBaun;Emily L. Niemitz;D. Elizabeth McNeil;Sheri A. Brandenburg

  • Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment

    Khiem C. Lam;Romina E. Araya;April Huang;Quanyi Chen

  • Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice

    Maxwell P. Lee;Jason D. Ravenel;Ren-Ju Hu;Lawrence R. Lustig

  • LIT1, an Imprinted Antisense RNA in the Human KvLQT1 Locus Identified by Screening for Differentially Expressed Transcripts Using Monochromosomal Hybrids

    Kohzoh Mitsuya;Makiko Meguro;Maxwell P. Lee;Motonobu Katoh

  • Bromodomain 4 activation predicts breast cancer survival

    Nigel P. S. Crawford;Jude Alsarraj;Luanne Lukes;Renard C. Walker

  • Global gene expression profiling and validation in esophageal squamous cell carcinoma and its association with clinical phenotypes

    Hua Su;Nan Hu;Howard H Yang;Chaoyu Wang

  • Structure of the Drosophila DNA topoisomerase II gene: Nucleotide sequence and homology among topoisomerases II

    Elizabeth E Wyckoff;Donna Natalie;James M. Nolan;Maxwell Lee

  • DNA topoisomerase I is essential in Drosophila melanogaster

    Maxwell P. Lee;Sheryl D. Brown;Alice Chen;Tao-Shih Hsieh

  • Low Frequency of p57KIP2 Mutation in Beckwith-Wiedemann Syndrome

    Maxwell P. Lee;Michael DeBaun;Gurvaneet Randhawa;Betty A. Reichard

  • Computational Analysis and Experimental Validation of Tumor-associated Alternative RNA Splicing in Human Cancer

    Zhining Wang;H. Shuen Lo;Howard Yang;Sheryl Gere

  • Delineating Genetic Alterations for Tumor Progression in the MCF10A Series of Breast Cancer Cell Lines

    Mitsutaka Kadota;Howard H. Yang;Bianca Gomez;Misako Sato

  • Genome wide analysis of DNA copy number neutral loss of heterozygosity (CNNLOH) and its relation to gene expression in esophageal squamous cell carcinoma

    Nan Hu;Robert J Clifford;Howard H Yang;Chaoyu Wang

  • Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations

    Chen Wu;Zhaoming Wang;Zhaoming Wang;Xin Song;Xin Song;Xiao-Shan Feng

  • Aberrant Splicing but not Mutations of TSG101 in Human Breast Cancer

    Maxwell P. Lee;Andrew P. Feinberg

  • Identification of Novel Gene Amplifications in Breast Cancer and Coexistence of Gene Amplification with an Activating Mutation of PIK3CA

    Mitsutaka Kadota;Misako Sato;Beverly Duncan;Akira Ooshima

Frequent Co-Authors

Alisa M. Goldstein
Alisa M. Goldstein National Institutes of Health
Andrew P. Feinberg
Andrew P. Feinberg Johns Hopkins University
Kent W. Hunter
Kent W. Hunter National Institutes of Health
Ying Hu
Ying Hu National Institutes of Health
Glenn Merlino
Glenn Merlino National Institutes of Health
Kenneth H. Buetow
Kenneth H. Buetow Arizona State University
Philip R. Taylor
Philip R. Taylor Cardiff University
Amy Hutchinson
Amy Hutchinson National Cancer Institute
Zhaoming Wang
Zhaoming Wang St. Jude Children's Research Hospital
Meredith Yeager
Meredith Yeager Hood College

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