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Biology and Biochemistry

D-Index
99
Citations
33476
World Ranking
1596
National Ranking
894

Research.com Recognitions

  • 2016 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Glenn Merlino is affiliated with the National Institutes of Health in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work primarily focuses on molecular biology, oncology, immunology, cancer research, and biomedical engineering.

The scientist's main topics of research include:

  • Immunotherapy and Immune Responses
  • Single-cell and spatial transcriptomics
  • Cancer Immunotherapy and Biomarkers
  • Cancer Genomics and Diagnostics
  • CAR-T cell therapy research
  • Melanoma and MAPK Pathways
  • Immune cells in cancer

Glenn Merlino has published frequently in highly regarded journals. The main venues for their publications include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Medicine
  • Clinical Cancer Research
  • Cancer Cell

Notable recent publications by Merlino cover melanoma and cancer immunotherapy:

  • "Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response" (2021) published in Science
  • "Melanoma models for the next generation of therapies" (2021) published in Cancer Cell
  • "Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy" (2020) published in Nature Medicine
  • "The State of Melanoma: Emergent Challenges and Opportunities" (2021) published in Clinical Cancer Research
  • "Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis" (2020) published in Nature Communications

Frequent coauthors in their work include:

  • Chi-Ping Day
  • Eva Pérez-Guijarro
  • Kerrie L. Marie
  • Maxwell P. Lee
  • Salem Malikić

Glenn Merlino was awarded the designation of Fellow of the American Association for the Advancement of Science (AAAS) in 2016.

Best Publications

  • The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection

    Cornelia M. Gorman;Glenn T. Merlino;Mark C. Willingham;Ira Pastan

  • TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas.

    Chamelli Jhappan;Cheryl Stahle;Richard N. Harkins;Nelson Fausto

  • Identification of essential genes for cancer immunotherapy

    Shashank J. Patel;Neville E. Sanjana;Rigel J. Kishton;Arash Eidizadeh

  • Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators

    Yanlin Yu;Javed Khan;Chand Khanna;Lee Helman

  • The Two Faces of Interferon-γ in Cancer

    M. Raza Zaidi;Glenn Merlino

  • Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor

    Hisashi Takayama;William J. LaRochelle;Richard Sharp;Toshiyuki Otsuka

  • Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges

    Chi Ping Day;Glenn Merlino;Terry Van Dyke

  • Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene.

    Thierry J. Velu;Laura Beguinot;William C. Vass;Mark C. Willingham

  • Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

    Yu An Yang;Oksana Dukhanina;Binwu Tang;Mizuko Mamura

  • Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning

    Giulia Celli;William J. LaRochelle;Susan Mackem;Richard Sharp

  • Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

    Xiaodong Feng;Xiaodong Feng;Maria Sol Degese;Ramiro Iglesias-Bartolome;Jose P. Vaque

  • Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands.

    C Jhappan;D Gallahan;C Stahle;E Chu

  • Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene

    Shunsuke Ishii;Young-Hua Xu;Randy H. Stratton;Bruce A. Roe

  • Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells

    Glenn T. Merlino;Young Hua Xu;Shunsuke Ishii;Adrian J.L. Clark

  • Neonatal sunburn and melanoma in mice

    Frances P. Noonan;Juan A. Recio;Hisashi Takayama;Paul Duray

  • Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells.

    Young-hua Xu;Shunsuke Ishii;Adrian J. L. Clark;Margery Sullivan

  • Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha.

    Justina C. Wu;Glenn Merlino;Nelson Fausto

  • Rhabdomyosarcoma--working out the pathways.

    Glenn Merlino;Lee J Helman

  • Ultraviolet radiation and cutaneous malignant melanoma.

    Chamelli Jhappan;Frances P Noonan;Glenn Merlino

  • Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.

    James G. Taylor Vi;Adam T. Cheuk;Patricia S. Tsang;Joon-Yong Chung

Frequent Co-Authors

Ira Pastan
Ira Pastan Center for Cancer Research
Maxwell P. Lee
Maxwell P. Lee National Institutes of Health
Paul S. Meltzer
Paul S. Meltzer National Institutes of Health
Sean Davis
Sean Davis National Institutes of Health
David E. Fisher
David E. Fisher Harvard University
Gilbert H. Smith
Gilbert H. Smith National Institutes of Health
Heinz Arnheiter
Heinz Arnheiter National Institutes of Health
Lee J. Helman
Lee J. Helman Children's Hospital of Los Angeles
Robert B. Dickson
Robert B. Dickson Georgetown University Medical Center

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