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Medicine

D-Index
108
Citations
38795
World Ranking
6050
National Ranking
3236

Overview

Peter J. Houghton is affiliated with The University of Texas Health Science Center at San Antonio in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology. The scientist has contributed to fields such as molecular biology, oncology, pulmonary and respiratory medicine, cancer research, and neurology.

Their work covers key topics including:

  • Sarcoma Diagnosis and Treatment
  • CAR-T cell therapy research
  • Neuroblastoma Research and Treatments
  • Cancer-related molecular mechanisms research
  • Cancer, Hypoxia, and Metabolism
  • Cancer Genomics and Diagnostics
  • Protein Degradation and Inhibitors

Among recent publications, notable papers include:

  • The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models, 2021, Clinical Cancer Research
  • Predicting and characterizing a cancer dependency map of tumors with deep learning, 2021, Science Advances
  • Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma, 2022, npj Precision Oncology
  • Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma, 2021, Nature Communications
  • Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease, 2020, Oncotarget

The scientist frequently publishes in these venues:

  • Cancer Research
  • Pediatric Blood & Cancer
  • Cell Reports
  • Molecular Cancer Therapeutics
  • Clinical Cancer Research

Peter J. Houghton collaborates regularly with several researchers, including:

  • Raushan T. Kurmasheva
  • Malcolm A. Smith
  • Stephen W. Erickson
  • Richard Görlick
  • Yidong Chen

Best Publications

  • The tor pathway: a target for cancer therapy

    Mary-Ann Bjornsti;Peter J. Houghton

  • Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

    Gregory J. Brunn;Christine C. Hudson;Aleksandar Sekulić;Aleksandar Sekulić;Aleksandar Sekulić;Josie M. Williams

  • mTOR and cancer therapy.

    J B Easton;P J Houghton

  • Targeting mTOR signaling for cancer therapy.

    Shile Huang;Peter J Houghton

  • Establishment of human tumor xenografts in immunodeficient mice.

    Christopher L Morton;Peter J Houghton

  • The pediatric preclinical testing program: description of models and early testing results.

    Peter J. Houghton;Christopher L. Morton;Chandra Tucker;Debbie Payne

  • Methods to Detect P-Glycoprotein-associated Multidrug Resistance in Patients' Tumors: Consensus Recommendations

    William T. Beck;Thomas M. Grogan;Cheryl L. Willman;Carlos Cordon-Cardo

  • A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

    Sajid Khan;Xuan Zhang;Dongwen Lv;Qi Zhang

  • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors

    Peter J. Houghton;Pamela J. Cheshire;James D. Hallman;Lois Lutz

  • Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro.

    Peter J. Houghton;Glen S. Germain;Franklin C. Harwood;John D. Schuetz

  • Rapamycins: mechanism of action and cellular resistance.

    Shile Huang;Mary Ann Bjornsti;Peter J. Houghton

  • Irinotecan Therapy in Adults With Recurrent or Progressive Malignant Glioma

    Henry S. Friedman;William P. Petros;Allan H. Friedman;Larry J. Schaaf

  • Rapamycin Causes Poorly Reversible Inhibition of mTOR and Induces p53-independent Apoptosis in Human Rhabdomyosarcoma Cells

    Hajime Hosoi;Michael B. Dilling;Takuma Shikata;Linda N. Liu

  • A specific chromosomal abnormality in rhabdomyosarcoma

    Edwin C. Douglass;M. Valentine;E. Etcubanas;D. Parham

  • mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α

    Hakan Cam;John B. Easton;Anthony High;Peter J. Houghton;Peter J. Houghton

  • Potentiation of neuroblastoma metastasis by loss of caspase-8.

    Dwayne G. Stupack;Tal Teitz;Matthew D. Potter;David Mikolon

  • Biochemical Correlates of mTOR Inhibition by the Rapamycin Ester CCI-779 and Tumor Growth Inhibition

    Lorina Dudkin;Michael B. Dilling;Pamela J. Cheshire;Franklin C. Harwood

  • Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors.

    Osama M. El-Badry;Caterina Minniti;Elise C. Kohn;Peter J. Houghton

  • Amplification of the gli Gene in Childhood Sarcomas

    Roberts Wm;Douglass Ec;Peiper Sc;Houghton Pj

  • Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development.

    J.K. Peterson;P.J. Houghton

Frequent Co-Authors

Malcolm A. Smith
Malcolm A. Smith National Institutes of Health
Richard Gorlick
Richard Gorlick The University of Texas MD Anderson Cancer Center
John M. Maris
John M. Maris Children's Hospital of Philadelphia
C. Patrick Reynolds
C. Patrick Reynolds Texas Tech University Health Sciences Center
Janet A. Houghton
Janet A. Houghton Cleveland Clinic
Clinton F. Stewart
Clinton F. Stewart St. Jude Children's Research Hospital
Henry S. Friedman
Henry S. Friedman Duke University
John Easton
John Easton St. Jude Children's Research Hospital
Cheryl A. London
Cheryl A. London Tufts University
Shile Huang
Shile Huang Louisiana State University Health Sciences Center Shreveport

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