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Medicine

D-Index
91
Citations
29380
World Ranking
11791
National Ranking
6046

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Lee J. Helman is affiliated with the Children's Hospital of Los Angeles in the United States. Their research focuses on several areas within medicine and biochemistry, genetics, and molecular biology, with a particular emphasis on molecular biology and oncology. Their work spans subfields such as pulmonary and respiratory medicine, pathology and forensic medicine, and cancer research.

The scientist has contributed to topics including sarcoma diagnosis and treatment, cancer-related gene regulation, lymphoma diagnosis and treatment, cell adhesion molecules research, cancer, hypoxia, and metabolism, Hippo pathway signaling and YAP/TAZ, and RNA modifications and cancer.

Frequent publication venues for Lee J. Helman include:

  • Cancer Research
  • Journal of Clinical Oncology
  • Molecular Cancer Therapeutics
  • Clinical Cancer Research
  • Cancer

Co-authors frequently collaborating with Lee J. Helman are:

  • Brigitte C. Widemann
  • John Glod
  • Christine M. Heske
  • Katherine K. Slemmons
  • Paul S. Meltzer

Some recent papers authored or co-authored by Lee J. Helman include:

  • The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer, 2023, Journal of Clinical Oncology
  • SARC025 arms 1 and 2: A phase 1 study of the poly(ADP-ribose) polymerase inhibitor niraparib with temozolomide or irinotecan in patients with advanced Ewing sarcoma, 2020, Cancer
  • EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth, 2020, Molecular Cancer Therapeutics
  • CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma, 2020, Molecular Cancer Therapeutics
  • Results of a Randomized, Double-Blinded, Placebo-Controlled, Phase 2.5 Study of Saracatinib (AZD0530), in Patients with Recurrent Osteosarcoma Localized to the Lung, 2020, Sarcoma

Lee J. Helman is a member of the Association of American Physicians.

Best Publications

  • Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

    Paul F. Robbins;Richard A. Morgan;Steven A. Feldman;James C. Yang

  • The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis.

    Chand Khanna;Xiaolin Wan;Seuli Bose;Ryan Cassaday

  • Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

    X Wan;B Harkavy;N Shen;P Grohar

  • Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators

    Yanlin Yu;Javed Khan;Chand Khanna;Lee Helman

  • Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

    Katherine A. Janeway;Su Young Kim;Maya Lodish;Vânia Nosé

  • Mechanisms of sarcoma development

    Lee J. Helman;Paul Meltzer

  • Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells

    Hua Zhang;Kevin S Chua;Martin Guimond;Veena Kapoor

  • Presurgical Chemotherapy Compared With Immediate Surgery and Adjuvant Chemotherapy for Nonmetastatic Osteosarcoma: Pediatric Oncology Group Study POG-8651

    Allen M. Goorin;Douglas J. Schwartzentruber;Meenakshi Devidas;Mark C. Gebhardt

  • Rhabdomyosarcoma: An Overview

    Ramzi Dagher;Lee Helman

  • Insulin-like Growth Factors and Cancer

    Derek LeRoith;Renato Baserga;Lee Helman;Charles T. Roberts

  • R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study

    Alberto S. Pappo;Shreyaskumar R. Patel;John Crowley;Denise K. Reinke

  • Phase 0 Clinical Trial of the Poly (ADP-Ribose) Polymerase Inhibitor ABT-888 in Patients With Advanced Malignancies

    Shivaani Kummar;Robert Kinders;Martin E. Gutierrez;Larry Rubinstein

  • Metastasis-associated differences in gene expression in a murine model of osteosarcoma.

    Chand Khanna;Javed Khan;Phoungmai Nguyen;Jennifer Prehn

  • Rhabdomyosarcoma--working out the pathways.

    Glenn Merlino;Lee J Helman

  • Molecular Subtypes of KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Gastrointestinal Stromal Tumor Clinic.

    Sosipatros A. Boikos;Alberto S. Pappo;J. Keith Killian;Michael P. LaQuaglia

  • Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.

    James G. Taylor Vi;Adam T. Cheuk;Patricia S. Tsang;Joon-Yong Chung

  • Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor

    J. Keith Killian;Su Young Kim;Markku Miettinen;Carly Smith

  • New Horizons in the Treatment of Osteosarcoma.

    Paul S Meltzer;Lee J Helman

  • Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors.

    Osama M. El-Badry;Caterina Minniti;Elise C. Kohn;Peter J. Houghton

  • Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma.

    Shili Zhan;David N. Shapiro;Lee J. Helman

Frequent Co-Authors

Paul S. Meltzer
Paul S. Meltzer National Institutes of Health
Crystal L. Mackall
Crystal L. Mackall Stanford University
Maria Tsokos
Maria Tsokos Beth Israel Deaconess Medical Center
Seth M. Steinberg
Seth M. Steinberg National Institutes of Health
Javed Khan
Javed Khan National Institutes of Health
Derek LeRoith
Derek LeRoith Icahn School of Medicine at Mount Sinai
Richard Gorlick
Richard Gorlick The University of Texas MD Anderson Cancer Center
Piero Picci
Piero Picci University of Bologna
Natasha J. Caplen
Natasha J. Caplen National Institutes of Health
Jeffrey A. Toretsky
Jeffrey A. Toretsky Georgetown University

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