Member of the Association of American Physicians
His primary areas of study are Internal medicine, Endocrinology, Insulin-like growth factor, Insulin and Insulin receptor. His research combines Type 2 diabetes and Internal medicine. His biological study spans a wide range of topics, including Gene expression and Phosphorylation, Cell biology.
Derek LeRoith combines subjects such as Autocrine signalling, Cell growth, Growth hormone, Molecular biology and Messenger RNA with his study of Insulin-like growth factor. His study in Insulin is interdisciplinary in nature, drawing from both Protein kinase B, AMPK and Type 2 Diabetes Mellitus. His studies in Insulin receptor integrate themes in fields like Insulin-like growth factor 1 receptor and Signal transduction, Biochemistry.
Derek LeRoith mainly investigates Internal medicine, Endocrinology, Insulin, Receptor and Diabetes mellitus. As a member of one scientific family, Derek LeRoith mostly works in the field of Internal medicine, focusing on Type 2 diabetes and, on occasion, Cognition. His Endocrinology research includes themes of Gene expression, Signal transduction and Growth factor.
He focuses mostly in the field of Receptor, narrowing it down to matters related to Cancer research and, in some cases, Cancer cell. The study incorporates disciplines such as Obesity, Disease, Bioinformatics and Intensive care medicine in addition to Diabetes mellitus. Derek LeRoith has researched Insulin receptor in several fields, including Insulin-like growth factor 1 receptor and Phosphorylation, Cell biology.
His primary areas of investigation include Internal medicine, Type 2 diabetes, Endocrinology, Diabetes mellitus and Insulin. His work in Internal medicine tackles topics such as Oncology which are related to areas like Epidemiology. His work on Adipose tissue as part of general Endocrinology study is frequently linked to Caspase 3, bridging the gap between disciplines.
His work deals with themes such as Surgery, Disease, Haptoglobin and Intensive care medicine, which intersect with Diabetes mellitus. Derek LeRoith studies Insulin, focusing on Insulin receptor in particular. His research integrates issues of Insulin-like growth factor 1 receptor, Cancer research and Receptor in his study of Insulin receptor.
The scientist’s investigation covers issues in Internal medicine, Endocrinology, Type 2 diabetes, Diabetes mellitus and Hyperinsulinemia. His Internal medicine research is multidisciplinary, relying on both Oncology and Bioinformatics. His Endocrinology study combines topics from a wide range of disciplines, such as Mammary tumor and Bone marrow.
His Type 2 diabetes study incorporates themes from Type 1 diabetes, Cognition, Cognitive decline and Glycemic. His Diabetes mellitus research is multidisciplinary, incorporating perspectives in Adverse effect, Surgery and Intensive care medicine. His Hyperinsulinemia research incorporates elements of Cancer, Dyslipidemia and PI3K/AKT/mTOR pathway.
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Molecular and cellular aspects of the insulin-like growth factor I receptor
Derek LeRoith;Haim Werner;Dana Beitner-Johnson;Charles T. Roberts.
Endocrine Reviews (1995)
Normal growth and development in the absence of hepatic insulin-like growth factor I
Shoshana Yakar;Jun L.I. Liu;Bethel Stannard;Andrew Butler.
Proceedings of the National Academy of Sciences of the United States of America (1999)
The insulin-like growth factor system and cancer.
Derek LeRoith;Charles T. Roberts.
Cancer Letters (2003)
The role of the IGF system in cancer growth and metastasis: overview and recent insights.
Amir Abbas Samani;Shoshana Yakar;Derek LeRoith;Pnina Brodt.
Endocrine Reviews (2007)
Circulating levels of IGF-1 directly regulate bone growth and density
Shoshana Yakar;Clifford J. Rosen;Wesley G. Beamer;Cheryl L. Ackert-Bicknell.
Journal of Clinical Investigation (2002)
Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
Klara Sjögren;Jun-Li Liu;Kristina Blad;Stanko Skrtic.
Proceedings of the National Academy of Sciences of the United States of America (1999)
Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways
Marcelina Párrizas;Alan R. Saltiel;Derek LeRoith.
Journal of Biological Chemistry (1997)
Developmental and Tissue-Specific Sulfonylurea Receptor Gene Expression
Catalina Hernández-Sánchez;Teresa L. Wood;Derek LeRoith.
Endocrinology (1997)
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
Keren Paz;Rina Hemi;Derek LeRoith;Avraham Karasik.
Journal of Biological Chemistry (1997)
Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity.
Ann Hellstrom;Carole Perruzzi;Meihua Ju;Eva Engström.
Proceedings of the National Academy of Sciences of the United States of America (2001)
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