World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
141
Citations
68132
World Ranking
1640
National Ranking
955

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Derek LeRoith is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology with extensive work focused on oncology and related molecular biology topics.

The scientist's research output includes 203 publications in Medicine and 59 in Biochemistry, Genetics, and Molecular Biology. Their subfields of concentration involve Oncology, Molecular Biology, Pulmonary and Respiratory Medicine, Cancer Research, and Epidemiology. Key topics covered in their work include:

  • Metabolism, Diabetes, and Cancer
  • Cancer Immunotherapy and Biomarkers
  • Cancer, Lipids, and Metabolism
  • Advanced Breast Cancer Therapies
  • Cancer Risks and Factors
  • COVID-19 Clinical Research Studies
  • Neuroendocrine Tumor Research Advances

Recent notable papers co-authored by Derek LeRoith include:

  • Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19 (2020) published in JAMA Internal Medicine
  • Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States (2020) published in American Journal of Kidney Diseases
  • Obesity, Type 2 Diabetes, and Cancer Risk (2021) published in Frontiers in Oncology
  • Hyperinsulinaemia in cancer (2020) published in Nature Reviews. Cancer
  • Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19 (2021) published in Annals of Internal Medicine

Derek LeRoith frequently collaborates with other researchers, with repeated co-authors including Amanda Leiter, Nina A. Bickell, Che-Kai Tsao, and George Mellgard, alongside numerous publications with themselves as first or corresponding author.

Their work has been published consistently in prominent journals such as the Journal of the Endocrine Society, Journal of Clinical Oncology, Endocrine Practice, Science Translational Medicine, and JCI Insight.

Recognition includes membership in the Association of American Physicians, reflecting their participation in professional organizations within the broader medical and scientific community.

Best Publications

  • Molecular and cellular aspects of the insulin-like growth factor I receptor

    Derek LeRoith;Haim Werner;Dana Beitner-Johnson;Charles T. Roberts

  • Normal growth and development in the absence of hepatic insulin-like growth factor I

    Shoshana Yakar;Jun L.I. Liu;Bethel Stannard;Andrew Butler

  • The insulin-like growth factor system and cancer.

    Derek LeRoith;Charles T. Roberts

  • The role of the IGF system in cancer growth and metastasis: overview and recent insights.

    Amir Abbas Samani;Shoshana Yakar;Derek LeRoith;Pnina Brodt

  • Circulating levels of IGF-1 directly regulate bone growth and density

    Shoshana Yakar;Clifford J. Rosen;Wesley G. Beamer;Cheryl L. Ackert-Bicknell

  • Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

    Klara Sjögren;Jun-Li Liu;Kristina Blad;Stanko Skrtic

  • Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

    Marcelina Párrizas;Alan R. Saltiel;Derek LeRoith

  • Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality.

    Emily Jane Gallagher;Derek LeRoith

  • A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation

    Keren Paz;Rina Hemi;Derek LeRoith;Avraham Karasik

  • Developmental and Tissue-Specific Sulfonylurea Receptor Gene Expression

    Catalina Hernández-Sánchez;Teresa L. Wood;Derek LeRoith

  • American association of clinical endocrinologists and american college of endocrinology - clinical practice guidelines for developing a diabetes mellitus comprehensive care plan - 2015.

    Yehuda Handelsman;Zachary T. Bloomgarden;George Grunberger;Guillermo Umpierrez

  • Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity.

    Ann Hellstrom;Carole Perruzzi;Meihua Ju;Eva Engström

  • Serum insulin-like growth factor I regulates brain amyloid-beta levels.

    Carro E;Trejo Jl;Gomez-Isla T;LeRoith D

  • Diabetes mellitus : a fundamental and clinical text

    Derek LeRoith;Simeon I. Taylor;Jerrold M. Olefsky

  • Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis.

    Yiping Wu;Shoshana Yakar;Ling Zhao;Lothar Hennighausen

  • Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene

    Haim Werner;Eddy Karnieli;Frank J. Rauscher;Derek Leroith

  • Treatment of Diabetes in Older Adults: An Endocrine Society Clinical Practice Guideline

    Derek LeRoith;Geert Jan Biessels;Susan S Braithwaite;Susan S Braithwaite;Felipe F Casanueva

  • Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II

    C. Bondy;H. Werner;C.T. Roberts;D. LeRoith

  • Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo

    Hiroshi Inoue;Wataru Ogawa;Michitaka Ozaki;Sanae Haga

  • Insulin-like Growth Factors and Cancer

    Derek LeRoith;Renato Baserga;Lee Helman;Charles T. Roberts

Frequent Co-Authors

Charles T. Roberts
Charles T. Roberts Oregon National Primate Research Center
Shoshana Yakar
Shoshana Yakar New York University
Martin L. Adamo
Martin L. Adamo The University of Texas Health Science Center at San Antonio
Jeremy M. Silverman
Jeremy M. Silverman Icahn School of Medicine at Mount Sinai
James Schmeidler
James Schmeidler Icahn School of Medicine at Mount Sinai
Mary Sano
Mary Sano Icahn School of Medicine at Mount Sinai
Joseph Shiloach
Joseph Shiloach National Institutes of Health
Mohan K. Raizada
Mohan K. Raizada University of Florida
Yehiel Zick
Yehiel Zick Weizmann Institute of Science
Oksana Gavrilova
Oksana Gavrilova National Institutes of Health

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