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Biology and Biochemistry

D-Index
75
Citations
20669
World Ranking
5298
National Ranking
2516

Overview

Shoshana Yakar is affiliated with New York University in the United States and conducts research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Endocrinology, Diabetes and Metabolism, Molecular Biology, Physiology, and Genetics.

The scientist's research focuses on several key topics, reflecting a diverse but interconnected range of interests. These include Growth Hormone and Insulin-like Growth Factors, Adipose Tissue and Metabolism, Bone Metabolism and Diseases, Diabetes Treatment and Management, Metabolism, Diabetes, and Cancer, TGF-β signaling in diseases, and Pancreatic function and diabetes.

Shoshana Yakar has contributed to a number of scientific publications over recent years. Selected recent papers include:

  • Effects of GH/IGF axis on bone and cartilage, 2020, Molecular and Cellular Endocrinology
  • Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease, 2021, Cells
  • Effects of GH/IGF on the Aging Mitochondria, 2020, Cells
  • Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan, 2021, Aging Cell
  • GH directly inhibits steatosis and liver injury in a sex-dependent and IGF1-independent manner, 2020, Journal of Endocrinology

Their scholarly output is frequently published in journals such as Aging Cell, GeroScience, bioRxiv (Cold Spring Harbor Laboratory), Cells, and JBMR Plus. These venues represent significant platforms in the fields of aging, molecular biology, and metabolism research.

Collaborative work forms an important aspect of Shoshana Yakar's research. Frequent coauthors include:

  • Sher Bahadur Poudel
  • Gozde Yildirim
  • Manisha Dixit
  • Ryan Richard Ruff
  • John J. Kopchick

The combination of expertise in endocrinology, molecular biology, and physiology supports an integrated approach to addressing complex questions related to hormone functions, metabolic regulation, and disease pathways. The scientist's research provides insight into how growth hormone and related signaling pathways influence aging, metabolism, and disease processes, particularly diabetes and bone metabolism.

Best Publications

  • Normal growth and development in the absence of hepatic insulin-like growth factor I

    Shoshana Yakar;Jun L.I. Liu;Bethel Stannard;Andrew Butler

  • The role of the IGF system in cancer growth and metastasis: overview and recent insights.

    Amir Abbas Samani;Shoshana Yakar;Derek LeRoith;Pnina Brodt

  • Circulating levels of IGF-1 directly regulate bone growth and density

    Shoshana Yakar;Clifford J. Rosen;Wesley G. Beamer;Cheryl L. Ackert-Bicknell

  • Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

    Lingling Xian;Xiangwei Wu;Xiangwei Wu;Lijuan Pang;Lijuan Pang;Michael Lou

  • Liver-Specific igf-1 Gene Deletion Leads to Muscle Insulin Insensitivity

    Shoshana Yakar;Jun Li Liu;Ana M. Fernandez;Yiping Wu

  • Functional inactivation of the igf-I and insulin receptors in skeletal muscle causes type 2 diabetes

    Ana M. Fernández;Jason K. Kim;Shoshana Yakar;Joëlle Dupont

  • Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1.

    Derek LeRoith;Shoshana Yakar

  • Biological effects of growth hormone on carbohydrate and lipid metabolism.

    Archana Vijayakumar;Ruslan Novosyadlyy;Ying Jie Wu;Shoshana Yakar

  • Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology.

    Andrew A Butler;Andrew A Butler;Shoshana Yakar;Ira H Gewolb;Michael Karas

  • Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes.

    Ruslan Novosyadlyy;Danielle E. Lann;Archana Vijayakumar;Anne Rowzee;Anne Rowzee

  • Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice

    Shoshana Yakar;Jennifer Setser;Hong Zhao;Bethel Stannard

  • Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors.

    Yiping Wu;Karen Cui;Keiko Miyoshi;Lothar Hennighausen

  • The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models.

    Shoshana Yakar;Derek LeRoith;Pnina Brodt

  • Peroxisome Proliferator–Activated Receptor-α Agonist Treatment in a Transgenic Model of Type 2 Diabetes Reverses the Lipotoxic State and Improves Glucose Homeostasis

    Homeostasis Kim;Martin Haluzik;Zeenat Asghar;Daphne Yau

  • PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells.

    Hong Zhao;Joelle Dupont;Shoshana Yakar;Michael Karas

  • 40 YEARS OF IGF1: Insulin-like growth factors: actions on the skeleton

    Shoshana Yakar;Haim Werner;Clifford J Rosen

  • Increased P85α Is a Potent Negative Regulator of Skeletal Muscle Insulin Signaling and Induces in Vivo Insulin Resistance Associated with Growth Hormone Excess

    Linda A. Barbour;Shaikh Mizanoor Rahman;Inga Gurevich;J. Wayne Leitner

  • The Intricate Role of Growth Hormone in Metabolism

    Archana Vijayakumar;Shoshana Yakar;Derek LeRoith

  • Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones.

    Shoshana Yakar;Nomeli P. Nunez;Patricia Pennisi;Pnina Brodt

  • Conditional Knockout of Mouse Insulin-Like Growth Factor-1 Gene Using the Cre/loxP System

    Jun Li Liu;Shoshana Yakar;Derek LeRoith

Frequent Co-Authors

Derek LeRoith
Derek LeRoith Icahn School of Medicine at Mount Sinai
Clifford J. Rosen
Clifford J. Rosen Maine Medical Center
John J. Kopchick
John J. Kopchick Ohio University
Stephen D. Hursting
Stephen D. Hursting University of North Carolina at Chapel Hill
Oksana Gavrilova
Oksana Gavrilova National Institutes of Health
Jan Frystyk
Jan Frystyk Odense University Hospital
Pinchas Cohen
Pinchas Cohen University of Southern California
Mary L. Bouxsein
Mary L. Bouxsein Beth Israel Deaconess Medical Center
Steven B. Abramson
Steven B. Abramson New York University
David R. Clemmons
David R. Clemmons University of North Carolina at Chapel Hill

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