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Biology and Biochemistry
Israel
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
120
Citations
83221
World Ranking
620
National Ranking
4

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Israel Leader Award
  • 2025 - Research.com Biology and Biochemistry in Israel Leader Award
  • 2023 - Research.com Biology and Biochemistry in Israel Leader Award
  • 2022 - Research.com Biology and Biochemistry in Israel Leader Award
  • 2016 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Biochemistry and Biophysics
  • 2013 - Fellow, National Academy of Inventors
  • 2009 - Member of Academia Europaea
  • 2009 - Centenary Prize, Royal Society of Chemistry (UK)
  • 2008 - Member of the National Academy of Medicine (NAM)
  • 2008 - Fellow of the American Academy of Arts and Sciences
  • 2007 - Member of the National Academy of Sciences
  • 2004 - Member of the European Academy of Sciences
  • 2004 - Nobel Prize for the discovery of ubiquitin-mediated protein degradation
  • 2000 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • Member of the European Molecular Biology Organization (EMBO)
  • Foreign Member, Chinese Academy of Sciences
  • Member of the European Academy of Sciences and Arts
  • Member of the Association of American Physicians
  • Member of the European Molecular Biology Organization (EMBO)
  • Foreign Member, Chinese Academy of Sciences
  • Member of the European Academy of Sciences and Arts
  • Member of the Association of American Physicians
  • Member of the European Molecular Biology Organization (EMBO)
  • Foreign Member, Chinese Academy of Sciences
  • Member of the European Academy of Sciences and Arts
  • Member of the Association of American Physicians

Overview

Aaron Ciechanover is affiliated with the Technion - Israel Institute of Technology in Israel. Their research spans extensive work in biochemistry, genetics, and molecular biology, with significant contributions also made in medicine. Their main specialized fields include molecular biology, oncology, immunology, epidemiology, and cancer research.

The scientist's research topics predominantly focus on ubiquitin and proteasome pathways, protein degradation and inhibitors, autophagy in disease and therapy, NF-κB signaling pathways, chemokine receptors and signaling, endoplasmic reticulum stress and disease, and mitochondrial function and pathology.

Frequent coauthors collaborating with Aaron Ciechanover include:

  • Ido Livneh (17 publications)
  • Jing An (8 publications)
  • Tamar Ziv (7 publications)
  • Yelena Kravtsova-Ivantsiv (7 publications)
  • Ziwei Huang (7 publications)

Publications are often found in the following venues:

  • Proceedings of the National Academy of Sciences (7 publications)
  • Cell Death and Differentiation (3 publications)
  • European Journal of Medicinal Chemistry (3 publications)
  • RSC Chemical Biology (2 publications)
  • Blood Reviews (2 publications)

Selected recent papers include:

  • "Apoptotic cell death in disease-Current understanding of the NCCD 2023," 2023, Cell Death and Differentiation
  • "p62-containing, proteolytically active nuclear condensates, increase the efficiency of the ubiquitin-proteasome system," 2021, Proceedings of the National Academy of Sciences
  • "The N-terminal cysteine is a dual sensor of oxygen and oxidative stress," 2021, Proceedings of the National Academy of Sciences
  • "Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects," 2020, Proceedings of the National Academy of Sciences
  • "Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors," 2020, Cancers

Aaron Ciechanover has received numerous awards including the Nobel Prize in 2004 for the discovery of ubiquitin-mediated protein degradation. Other distinctions include the Albert Lasker Award for Basic Medical Research in 2000, membership in the National Academy of Sciences since 2007, and fellowships in several prestigious scientific societies such as the American Academy of Arts and Sciences and the National Academy of Inventors.

Additional memberships include the German National Academy of Sciences Leopoldina, the European Academy of Sciences, the European Molecular Biology Organization (EMBO), and the Chinese Academy of Sciences. These affiliations reflect a career deeply engaged in advancing the understanding of molecular mechanisms in biology and medicine.

Best Publications

  • The Ubiquitin System

    Avram Hershko;Aaron Ciechanover

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction

    Michael H. Glickman;Aaron Ciechanover

  • The ubiquitin-proteasome proteolytic pathway

    Aaron Ciechanover

  • The ubiquitin system for protein degradation

    Avram Hershko;Aaron Ciechanover

  • The ubiquitin–proteasome pathway: on protein death and cell life

    Aaron Ciechanover

  • Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

    A Hershko;H Heller;S Elias;A Ciechanover

  • pH and the recycling of transferrin during receptor-mediated endocytosis

    Alice Dautry-Varsat;Aaron Ciechanover;Harvey F. Lodish

  • Proteolysis: from the lysosome to ubiquitin and the proteasome.

    Aaron Ciechanover

  • Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.

    Gil Levkowitz;Hadassa Waterman;Seth A Ettenberg;Menachem Katz

  • The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

    Aaron Ciechanover;Patrik Brundin

  • Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

    L. Galluzzi;J. M. Bravo-San Pedro;I. Vitale;S. A. Aaronson

  • Ubiquitin-mediated proteolysis: biological regulation via destruction.

    Aaron Ciechanover;Amir Orian;Alan L. Schwartz

  • Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

    Avram Hershko;Aaron Ciechanover;Hannah Heller;Arthur L. Haas

  • Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting.

    Aaron Ciechanover

  • Basic Medical Research Award. The ubiquitin system.

    Avram Hershko;Aaron Ciechanover;Alexander Varshavsky

  • Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.

    O. Staub;I. Gautschi;T. Ishikawa;K. Breitschopf

  • Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

    L. Galluzzi;L. Galluzzi;L. Galluzzi;S. A. Aaronson;J. Abrams;E. S. Alnemri

  • Mechanisms of intracellular protein breakdown

    and A Hershko;A Ciechanover

  • Ubiquitin-mediated protein degradation: The early days The ubiquitin system

    Avram Hershko;Aaron Ciechanover;Alexander Varshavsky

Frequent Co-Authors

Alan L. Schwartz
Alan L. Schwartz Washington University in St. Louis
Yong Tae Kwon
Yong Tae Kwon Seoul National University
Avram Hershko
Avram Hershko Technion – Israel Institute of Technology
Ashraf Brik
Ashraf Brik Technion – Israel Institute of Technology
Gerry Melino
Gerry Melino University of Rome Tor Vergata
Kazuhiro Iwai
Kazuhiro Iwai Kyoto University
Oliver Kepp
Oliver Kepp Institut Gustave Roussy
Thomas Sommer
Thomas Sommer Max Delbrück Center for Molecular Medicine
Martin Rechsteiner
Martin Rechsteiner University of Utah

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