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Mark Hochstrasser

Mark Hochstrasser

D-Index & Metrics

Biology and Biochemistry

D-Index
84
Citations
43681
World Ranking
3233
National Ranking
1636

Research.com Recognitions

  • 2016 - Fellow of the American Academy of Arts and Sciences
  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Mark Hochstrasser is affiliated with Yale University in the United States and specializes in the fields of Biochemistry, Genetics, and Molecular Biology. Their research activity is especially concentrated in Molecular Biology and Cell Biology, with additional work in Insect Science, Epidemiology, and Oncology.

The main topics addressed in Hochstrasser's work include:

  • Ubiquitin and proteasome pathways
  • Endoplasmic Reticulum Stress and Disease
  • Autophagy in Disease and Therapy
  • Insect symbiosis and bacterial influences
  • Peptidase Inhibition and Analysis
  • Cellular transport and secretion
  • RNA modifications and cancer

The scientist has published papers primarily in notable venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Genetics, Nucleic Acids Research, and Proceedings of the National Academy of Sciences.

Recent publications include:

  • "Histone sumoylation and chromatin dynamics," 2021, Nucleic Acids Research
  • "The Biochemistry of Cytoplasmic Incompatibility Caused by Endosymbiotic Bacteria," 2020, Genes
  • "Histone sumoylation promotes Set3 histone-deacetylase complex-mediated transcriptional regulation," 2020, Nucleic Acids Research
  • "Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors," 2021, Proceedings of the National Academy of Sciences
  • "SUMO and cellular adaptive mechanisms," 2020, Experimental & Molecular Medicine

Frequent collaborators include:

  • Mengwen Zhang
  • Jason M. Berk
  • Jianhui Li
  • Hong-Yeoul Ryu
  • Adrian B. Mehrtash

Throughout their career, Hochstrasser has received recognition such as becoming a Fellow of the American Association for the Advancement of Science (AAAS) in 2012 and a Fellow of the American Academy of Arts and Sciences in 2016.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

    Mark Hochstrasser

  • Modification of Proteins by Ubiquitin and Ubiquitin-Like Proteins

    Oliver Kerscher;Rachael Felberbaum;Mark Hochstrasser

  • Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation.

    Ping Xu;Duc M. Duong;Nicholas T. Seyfried;Dongmei Cheng

  • Mechanism and function of deubiquitinating enzymes.

    Alexander Y. Amerik;Mark Hochstrasser

  • Ubiquitin, proteasomes, and the regulation of intracellular protein degradation.

    Mark Hochstrasser

  • Origin and function of ubiquitin-like proteins

    Mark Hochstrasser

  • Diversity of degradation signals in the ubiquitin–proteasome system

    Tommer Ravid;Mark Hochstrasser

  • A new protease required for cell-cycle progression in yeast

    Shyr-Jiann Li;Mark Hochstrasser

  • Function and regulation of SUMO proteases

    Christopher M. Hickey;Nicole R. Wilson;Mark Hochstrasser

  • Substrate Targeting in the Ubiquitin System

    Jeffrey D. Laney;Mark Hochstrasser

  • A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matα2 repressor degradation

    Robert Swanson;Martin Locher;Mark Hochstrasser

  • Evolution and function of ubiquitin-like protein-conjugation systems

    Mark Hochstrasser

  • Autocatalytic Subunit Processing Couples Active Site Formation in the 20S Proteasome to Completion of Assembly

    Ping Chen;Mark Hochstrasser

  • Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATα2 repressor

    Ping Chen;Phoebe Johnson;Thomas Sommer;Stefan Jentsch

  • A superfamily of protein tags: ubiquitin, SUMO and related modifiers.

    David C. Schwartz;Mark Hochstrasser

  • The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

    Feroz R. Papa;Mark Hochstrasser

  • The Yeast ULP2 (SMT4) Gene Encodes a Novel Protease Specific for the Ubiquitin-Like Smt3 Protein

    Shyr-Jiann Li;Mark Hochstrasser

  • Defining the SUMO-modified Proteome by Multiple Approaches in Saccharomyces cerevisiae,

    J. Thomas Hannich;Alaron Lewis;Mary B. Kroetz;Shyr Jiann Li

  • Molecular architecture and assembly of the eukaryotic proteasome.

    Robert J. Tomko;Mark Hochstrasser

Frequent Co-Authors

Alexander Varshavsky
Alexander Varshavsky California Institute of Technology
John W. Sedat
John W. Sedat University of California, San Francisco
Richard D. Vierstra
Richard D. Vierstra Washington University in St. Louis
Daniel Finley
Daniel Finley Harvard University
Junmin Peng
Junmin Peng St. Jude Children's Research Hospital
Dieter H. Wolf
Dieter H. Wolf University of Stuttgart
Thomas Sommer
Thomas Sommer Max Delbrück Center for Molecular Medicine
Yong Xiong
Yong Xiong Yale University
Stefan Jentsch
Stefan Jentsch Max Planck Society
Yosef Gruenbaum
Yosef Gruenbaum Hebrew University of Jerusalem

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