Michael K. Pangburn

Overview

Best Publications

• Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution.

  M K Pangburn;R D Schreiber;H J Müller-Eberhard

  953
  Citations

• Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3.

  Michael K. Pangburn;Robert D. Schreiber;Hans J. Muller-Eberhard

  598
  Citations

• Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H.

  Seppo Meri;Michael K. Pangburn

  534
  Citations

• Complement C3 convertase: Cell surface restriction of β1H control and generation of restriction on neuraminidase-treated cells

  Michael K. Pangburn;Hans J. Müller-Eberhard

  466
  Citations

• Complement control protein factor H: The good, the bad, and the inadequate

  Viviana P. Ferreira;Michael K. Pangburn;Claudio Cortés

  463
  Citations

• Relation of putative thioester bond in C3 to activation of the alternative pathway and the binding of C3b to biological targets of complement.

  Michael K. Pangburn;Hans J. Muller-Eberhard

  438
  Citations

• Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria

  Michael K. Pangburn;Robert D. Schreiber;Hans J. Muller-Eberhard

  405
  Citations

• The Alternative Pathway of Complement

  Michael K. Pangburn;Hans J. Müller-Eberhard

  403
  Citations

• Binding of C4b-binding protein to porin: a molecular mechanism of serum resistance of Neisseria gonorrhoeae

  Sanjay Ram;Meabh Cullinane;Anna M. Blom;Sunita Gulati

  296
  Citations

• PspC, a pneumococcal surface protein, binds human factor H.

  Sandhya Dave;Alexis Brooks-Walter;Michael K. Pangburn;Larry S. McDaniel

  280
  Citations

• Activation of the Alternative Pathway of Complement by a Phosphorothioate Oligonucleotide: Potential Mechanism of Action

  Scott P. Henry;Patricia C. Giclas;Janet Leeds;Michael Pangburn

  260
  Citations

• Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional properties

  David E. Isenman;David I. C. Kells;Neil R. Cooper;Hans J. Mueller-Eberhard

  250
  Citations

• Localization of the heparin-binding site on complement factor H.

  M. K. Pangburn;M. A. L. Atkinson;S. Meri

  240
  Citations

• Host recognition and target differentiation by factor H, a regulator of the alternative pathway of complement.

  Michael K Pangburn

  229
  Citations

• Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins

  Robert D. Schreiber;Michael K. Pangburn;Philippe H. Lesavre;Hans J. Muller-Eberhard

  218
  Citations

• Cutting Edge: Localization of the Host Recognition Functions of Complement Factor H at the Carboxyl-Terminal: Implications for Hemolytic Uremic Syndrome

  Michael K. Pangburn

  188
  Citations

• Regulation of Alternative Pathway Complement Activation by Glycosaminoglycans: Specificity of the Polyanion Binding Site on Factor H

  S. Meri;M.K. Pangburn

  186
  Citations

• Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces.

  Viviana P. Ferreira;Andrew P. Herbert;Henry G. Hocking;Paul N. Barlow

  180
  Citations

• Properdin binds to sulfatide [Gal(3-SO4)beta 1-1 Cer] and has a sequence homology with other proteins that bind sulfated glycoconjugates.

  G D Holt;M K Pangburn;V Ginsburg

  180
  Citations

• Molecular architecture of human properdin, a positive regulator of the alternative pathway of complement.

  C A Smith;M K Pangburn;C W Vogel;H J Müller-Eberhard

  169
  Citations