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Chemistry

D-Index
62
Citations
10855
World Ranking
9044
National Ranking
508

Overview

Stephen J. Perkins is affiliated with University College London in the United Kingdom. Their research spans primarily the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on subfields such as Hematology, Molecular Biology, Immunology, Radiology, Nuclear Medicine and Imaging, and Genetics.

Their work addresses several main topics including:

  • Hemophilia Treatment and Research
  • Glycosylation and Glycoproteins Research
  • Platelet Disorders and Treatments
  • Complement system in diseases
  • Monoclonal and Polyclonal Antibodies Research
  • Protein purification and stability
  • Blood Coagulation and Thrombosis Mechanisms

Stephen J. Perkins has published extensively, with frequent appearances in journals such as:

  • Journal of Biological Chemistry
  • TH Open
  • Journal of Thrombosis and Haemostasis
  • PLoS ONE
  • Haemophilia

Selected recent papers include:

  • "The European Association for Haemophilia and Allied Disorders (EAHAD) Coagulation Factor Variant Databases: Important resources for haemostasis clinicians and researchers", 2020, Haemophilia
  • "The EAHAD blood coagulation factor VII variant database", 2020, Human Mutation
  • "An updated interactive database for 1692 genetic variants in coagulation factor IX provides detailed insights into hemophilia B", 2023, Journal of Thrombosis and Haemostasis
  • "Clinicopathologic Implications of Complement Genetic Variants in Kidney Transplantation", 2021, Frontiers in Medicine
  • "Analysis of 272 Genetic Variants in the Upgraded Interactive FXI Web Database Reveals New Insights into FXI Deficiency", 2021, TH Open

Frequent collaborators in their research include:

  • Jayesh Gor
  • Xin Gao
  • Paul A. Dalby
  • Victoria A. Harris
  • Valentina A. Spiteri

Best Publications

  • Protein volumes and hydration effects. The calculations of partial specific volumes, neutron scattering matchpoints and 280-nm absorption coefficients for proteins and glycoproteins from amino acid sequences.

    Stephen J. Perkins

  • The fab and fc fragments of IgA1 exhibit a different arrangement from that in IgG: a study by X-ray and neutron solution scattering and homology modelling

    Mark K Boehm;Jenny M Woof;Michael A Kerr;Stephen J Perkins

  • Folded-back solution structure of monomeric factor H of human complement by synchrotron X-ray and neutron scattering, analytical ultracentrifugation and constrained molecular modelling.

    Mohammed Aslam;Stephen J Perkins

  • Solution structure of human and mouse immunoglobulin M by synchrotron X-ray scattering and molecular graphics modelling. A possible mechanism for complement activation.

    Stephen J. Perkins;Adam S. Nealis;Brian J. Sutton;Arnold Feinstein

  • His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form.

    Simon J. Clark;Victoria A. Higman;Barbara Mulloy;Stephen J. Perkins

  • High resolution1H- and13C-N.M.R spectra ofD-glucopyranose, 2-acetamido-2-deoxy-D-glucopyranose, and related compounds in aqueous media

    Stephen J. Perkins;Louise N. Johnson;David C. Phillips;Raymond A. Dwek

  • Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.

    Amy J. Osborne;Matteo Breno;Nicolo Ghiringhelli Borsa;Fengxiao Bu;Fengxiao Bu

  • Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations

    Azubuike I. Okemefuna;Ruodan Nan;Ami Miller;Jayesh Gor

  • Pentameric and decameric structures in solution of serum amyloid P component by X-ray and neutron scattering and molecular modelling analyses.

    Ashton Aw;Boehm Mk;Gallimore;Pepys Mb

  • Temperature dependent molecular motion of a tyrosine residue of ferrocytochrome C

    Iain D. Campbell;Christopher M. Dobson;Geoffrey R. Moore;Stephen J. Perkins

  • Ring current effects in the conformation dependent NMR chemical shifts of aliphatic protons in the basic pancreatic trypsin inhibitor.

    Stephen J. Perkins;Kurt Wüthrich

  • Solution Structure Determination of Monomeric Human IgA2 by X-ray and Neutron Scattering, Analytical Ultracentrifugation and Constrained Modelling: A Comparison with Monomeric Human IgA1.

    Patricia B. Furtado;Patrick W. Whitty;Alexis Robertson;Julian T. Eaton

  • X-Ray and neutron scattering analyses of hydration shells: a molecular interpretation based on sequence predictions and modelling fits

    Stephen J. Perkins

  • Semi-rigid solution structures of heparin by constrained X-ray scattering modelling: new insight into heparin-protein complexes.

    Sanaullah Khan;Jayesh Gor;Barbara Mulloy;Stephen J. Perkins

  • Comparisons of ring-current shifts calculated from the crystal structure of egg white lysozyme of hen with the proton nuclear magnetic resonance spectrum of lysozyme in solution

    Stephen J. Perkins;Raymond A. Dwek

  • Immunoglobulin fold and tandem repeat structures in proteoglycan N-terminal domains and link protein.

    Stephen J. Perkins;Adam S. Nealis;Jayesh Dudhia;Timothy E. Hardingham

  • A study of the structure of human complement component factor H by Fourier transform infrared spectroscopy and secondary structure averaging methods.

    Stephen J. Perkins;Parvez I. Haris;Robert B. Sim;Dennis Chapman

  • Low-resolution structural studies of mitochondrial ubiquinol: Cytochrome c reductase in detergent solutions by neutron scattering

    Stephen J. Perkins;Hanns Weiss

  • Molecular modelling of the C-terminal domains of factor H of human complement: a correlation between haemolytic uraemic syndrome and a predicted heparin binding site

    Stephen J Perkins;Timothy H.J Goodship

  • Bent domain structure of recombinant human IgE-Fc in solution by X-ray and neutron scattering in conjunction with an automated curve fitting procedure.

    Andrew J. Beavil;Robert J. Young;Brian J. Sutton;Stephen J. Perkins

Frequent Co-Authors

Robert B. Sim
Robert B. Sim University of Oxford
Timothy H.J. Goodship
Timothy H.J. Goodship Newcastle University
V. Michael Holers
V. Michael Holers University of Colorado Denver
Barbara Mulloy
Barbara Mulloy Imperial College London
Joel M. Guthridge
Joel M. Guthridge Oklahoma Medical Research Foundation
Raymond A. Dwek
Raymond A. Dwek University of Oxford
Anthony J. Day
Anthony J. Day University of Manchester
Louise N. Johnson
Louise N. Johnson University of Oxford
Peter F. Zipfel
Peter F. Zipfel Friedrich Schiller University Jena
David L. Gordon
David L. Gordon Flinders Medical Centre

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