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Molecular Biology

D-Index
62
Citations
11563
World Ranking
1863
National Ranking
148

Overview

Paul N. Barlow is affiliated with the University of Edinburgh in the United Kingdom. Their research primarily focuses on several intersecting areas in the biomedical sciences, including immunology, molecular biology, and medicine. The scientist has contributed notably to studies on the complement system in diseases, protein structure and dynamics, and retinal diseases and treatments.

Barlow's main fields of study include:

  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, their subfields of study cover:

  • Immunology
  • Molecular Biology
  • Ophthalmology
  • Materials Chemistry
  • Spectroscopy

The topics most frequently addressed in Barlow's work include:

  • Complement system in diseases
  • Protein Structure and Dynamics
  • Retinal Diseases and Treatments
  • Enzyme Structure and Function
  • Mass Spectrometry Techniques and Applications
  • Immune cells in cancer
  • Immune Cell Function and Interaction

Barlow has published in several well-known scientific journals, with repeated contributions to:

  • Frontiers in Immunology
  • Journal of Biological Chemistry
  • Chemical Science
  • OncoImmunology
  • Current Eye Research

Some of the recent papers published by Paul N. Barlow include:

  • Complement inhibitor factor H expressed by breast cancer cells differentiates CD14 + human monocytes into immunosuppressive macrophages, 2020, OncoImmunology
  • Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A, 2020, Chemical Science
  • Energetics of a protein disorder-order transition in small molecule recognition, 2022, Chemical Science
  • Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice, 2021, Frontiers in Immunology
  • Functional Characterization of Rare Genetic Variants in the N-Terminus of Complement Factor H in aHUS, C3G, and AMD, 2021, Frontiers in Immunology

Frequent collaborators in Barlow's research team include:

  • Arun A. Gupta
  • Julien Michel
  • Andrew P. Herbert
  • Elisavet Makou
  • Lila M. Gierasch

Best Publications

  • Structure of the C3HC4 Domain by 1H-nuclear Magnetic Resonance Spectroscopy.: A New Structural Class of Zinc-finger

    Paul Barlow;B Luisi;A Milner;M Elliott

  • Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes

    Greta E Weiss;Paul R Gilson;Tana Taechalertpaisarn;Wai-Hong Tham

  • Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome

    Iain Moore;Lisa Strain;Isabel Pappworth;David Kavanagh

  • Three-dimensional structure of a complement control protein module in solution

    D.G. Norman;P.N. Barlow;M. Baron;A.J. Day

  • New Approaches to the Treatment of Dense Deposit Disease

    Richard J.H. Smith;Jessy Alexander;Paul N. Barlow;Marina Botto

  • Structural basis for engagement by complement factor H of C3b on a self surface

    Hugh P. Morgan;Christoph Q. Schmidt;Mara Guariento;Baerbel S. Blaum;Baerbel S. Blaum

  • Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand

    Wai Hong Tham;Danny W. Wilson;Sash Lopaticki;Christoph Q. Schmidt

  • Structural changes accompanying pH-induced dissociation of the beta-lactoglobulin dimer.

    Stanislava Uhrínová;Mark H. Smith;Geoffrey B. Jameson;Dusan Uhrín

  • Structure and flexibility of the multiple domain proteins that regulate complement activation.

    Marina D. Kirkitadze;Paul N. Barlow

  • A new map of glycosaminoglycan and C3b binding sites on factor H.

    Christoph Q. Schmidt;Andrew P. Herbert;David Kavanagh;Carina Gandy

  • Solution structure of a pair of complement modules by nuclear magnetic resonance.

    P.N. Barlow;A. Steinkasserer;D.G. Norman;B. Kieffer

  • The solution structure of the domain from MeCP2 that binds to methylated DNA

    Robert I.D Wakefield;Brian O Smith;Xinsheng Nan;Andrew Free

  • Structural basis for complement factor H–linked age-related macular degeneration

    Beverly E. Prosser;Steven Johnson;Pietro Roversi;Andrew P. Herbert

  • The Binding of Factor H to a Complex of Physiological Polyanions and C3b on Cells Is Impaired in Atypical Hemolytic Uremic Syndrome

    Viviana P. Ferreira;Andrew P. Herbert;Claudio Cortés;Kristi A. McKee

  • Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.

    Stanislava Uhrinova;Dusan Uhrin;Helen Powers;Kathryn Watt

  • Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces.

    Viviana P. Ferreira;Andrew P. Herbert;Henry G. Hocking;Paul N. Barlow

  • Translational Mini-Review Series on Complement Factor H: Structural and functional correlations for factor H

    C. Q. Schmidt;A. P. Herbert;H. G. Hocking;D. Uhrin

  • A parallel three stranded α-helical bundle at the nucleation site of collagen triple-helix formation

    Hans-Jürgen Hoppe;Paul N. Barlow;Kenneth B.M. Reid

  • Structural similarity between the p17 matrix protein of HIV-1 and interferon-γ

    Stephen Matthews;Paul Barlow;Jonathan Boyd;Geoff Barton

  • Dissecting sites important for complement regulatory activity in membrane cofactor protein (MCP; CD46).

    M. Kathryn Liszewski;Marilyn Leung;Wenying Cui;V. Bala Subramanian

Frequent Co-Authors

Dušan Uhrín
Dušan Uhrín University of Edinburgh
David J. Kavanagh
David J. Kavanagh Queensland University of Technology
John P. Atkinson
John P. Atkinson Washington University in St. Louis
Alan F. Cowman
Alan F. Cowman Walter and Eliza Hall Institute of Medical Research
Juri Rappsilber
Juri Rappsilber Technical University of Berlin
Robert B. Sim
Robert B. Sim University of Oxford
Nicholas C. Price
Nicholas C. Price University of Glasgow
Iain D. Campbell
Iain D. Campbell University of Oxford
Stephen Matthews
Stephen Matthews Imperial College London
Malcolm Lyon
Malcolm Lyon University of Manchester

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