Hiroyoshi Hidaka

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Best Publications

• Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

  Hiroyoshi Hidaka;Masaki Inagaki;Sachiyo Kawamoto;Yasuharu Sasaki

  4559
  Citations

• Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

  Takashi Chijiwa;Atsushi Mishima;Masatoshi Hagiwara;Mamoru Sano

  2249
  Citations

• KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II

  Hiroshi Tokumitsu;Takashi Chijiwa;Masatoshi Hagiwara;Akihiro Mizutani

  936
  Citations

• N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation

  Hiroyoshi Hidaka;Yasuharu Sasaki;Toshio Tanaka;Toyoshi Endo

  805
  Citations

• Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.

  M Saitoh;T Ishikawa;S Matsushima;M Naka

  720
  Citations

• 1-(5-isoquinol inesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase c in rabbit platelets

  Sachiyo Kawamoto;Hiroyoshi Hidaka

  614
  Citations

• The newly synthesized selective Ca2+calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells

  Mariko Sumi;Kazutoshi Kiuchi;Tomohiko Ishikawa;Akira Ishii

  611
  Citations

• Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial.

  Masato Shibuya;Yoshio Suzuki;Kenichiro Sugita;Isamu Saito

  606
  Citations

• Calmodulin and the cell cycle: Involvement in regulation of cell-cycle progression

  James G. Chafouleas;Wade E. Bolton;Hiroyoshi Hidaka;Aubrey E. Boyd

  543
  Citations

• Tissue-specific expression of three distinct types of rabbit protein kinase C

  Shigeo Ohno;Hiroshi Kawasaki;Shinobu Imajoh;Koichi Suzuki

  539
  Citations

• Hydrophobic regions function in calmodulin-enzyme(s) interactions.

  T Tanaka;H Hidaka

  512
  Citations

• Calcium-regulated modulator protein interacting agents inhibit smooth muscle calcium-stimulated protein kinase and ATPase.

  Hiroyoshi Hidaka;Tokuo Yamaki;Michiko Naka;Toshio Tanaka

  463
  Citations

• The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway.

  Yasuharu Sasaki;Masaaki Suzuki;Hiroyoshi Hidaka

  396
  Citations

• Ca2+-calmodulin-dependent phosphorylation and platelet secretion.

  Masakatsu Nishikawa;Toshio Tanaka;Hiroyoshi Hidaka

  364
  Citations

• Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains

  Michiko Naka;Masakatsu Nishikawa;Robert S. Adelstein;Hiroyoshi Hidaka

  349
  Citations

• Protein kinase C modulates in vitro phosphorylation of the smooth muscle heavy meromyosin by myosin light chain kinase.

  M Nishikawa;J R Sellers;R S Adelstein;H Hidaka

  334
  Citations

• Development of specific Rho-kinase inhibitors and their clinical application.

  Masahiro Tamura;Hiroshi Nakao;Hideo Yoshizaki;Masami Shiratsuchi

  281
  Citations

• Selective inhibitors of Ca2+-binding modulator of phosphodiesterase produce vascular relaxation and inhibit actin-myosin interaction.

  Hiroyoshi Hidaka;Tokuo Yamaki;Tsuyoshi Totsuka;Masahisa Asano

  276
  Citations

• Effects of Cilostazol, a Selective cAMP Phosphodiesterase Inhibitor on the Contraction of Vascular Smooth Muscle

  Toshio Tanaka;Tomohiko Ishikawa;Masatoshi Hagiwara;Koji Onoda

  264
  Citations

• Regulation of Neuronal Nitric-oxide Synthase by Calmodulin Kinases

  Yuji Hayashi;Masahiro Nishio;Yasuhito Naito;Hisayuki Yokokura

  249
  Citations