World's Best Scientists 2026 revealed!

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Medicine

D-Index
92
Citations
29832
World Ranking
11347
National Ranking
332

Overview

Shun Shimohama is affiliated with Sapporo Medical University in Japan and has contributed extensively to the fields of medicine and neuroscience. Their research spans a variety of topics predominantly centered on neurological disorders and molecular mechanisms underlying neurodegeneration.

The main fields of study for Shimohama include Medicine and Neuroscience, with a specific focus on subfields such as Neurology, Molecular Biology, Cellular and Molecular Neuroscience, Physiology, and Pathology and Forensic Medicine.

Themes central to their research encompass:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Nicotinic Acetylcholine Receptors Study
  • Amyotrophic Lateral Sclerosis Research
  • Parkinson's Disease Mechanisms and Treatments
  • Genetic Neurodegenerative Diseases
  • Neurogenetic and Muscular Disorders Research

Shimohama's recent publications include:

  • Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis, 2022, JAMA Neurology
  • Clinicopathologic Features of Oculopharyngodistal Myopathy With LRP12 CGG Repeat Expansions Compared With Other Oculopharyngodistal Myopathy Subtypes, 2021, JAMA Neurology
  • Roles of microglia in Alzheimer's disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention, 2021, Biochemical Pharmacology
  • HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data, 2021, Scientific Reports
  • Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer's Disease, 2022, Molecules

The frequent co-authors collaborating with Shimohama are:

  • Shin Hisahara
  • Kazuyuki Takata
  • Kaneyasu Nishimura
  • Daisuke Yamamoto
  • Koki Harada

Publication venues frequently chosen by Shimohama include:

  • Rinsho Shinkeigaku
  • Internal Medicine
  • JAMA Neurology
  • Scientific Reports
  • Proceedings for Annual Meeting of The Japanese Pharmacological Society

Best Publications

  • Oxidative damage is the earliest event in Alzheimer disease.

    Akihiko Nunomura;George Perry;Gjumrakch Aliev;Keisuke Hirai;Keisuke Hirai

  • Mitochondrial abnormalities in Alzheimer's disease.

    Keisuke Hirai;Gjumrakch Aliev;Akihiko Nunomura;Akihiko Nunomura;Hisashi Fujioka

  • Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study

    James F Howard;Kimiaki Utsugisawa;Michael Benatar;Hiroyuki Murai

  • Activation and Involvement of p38 Mitogen-activated Protein Kinase in Glutamate-induced Apoptosis in Rat Cerebellar Granule Cells *

    Hiroshi Kawasaki;Takaya Morooka;Shun Shimohama;Jun Kimura

  • α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity

    Takeshi Kihara;Shun Shimohama;Hideyuki Sawada;Kazuhiro Honda

  • Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity

    T. Kihara;S. Shimohama;H. Sawada;J. Kimura

  • Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins

    Jun Ichi Kakimura;Yoshihisa Kitamura;Kazuyuki Takata;Masaaki Umeki

  • Activation of NADPH oxidase in Alzheimer's disease brains.

    Shun Shimohama;Hiroko Tanino;Naoko Kawakami;Naoki Okamura

  • Changes in nicotinic and muscarinic cholinergic receptors in Alzheimer-type dementia.

    Shun Shimohama;Takashi Taniguchi;Motohatsu Fujiwara;Masakuni Kameyama

  • The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.

    Takashi Kageyama;Masaru Nakamura;Akinori Matsuo;Yasuomi Yamasaki

  • Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron

    Kazuhiro Honda;Mark A. Smith;Xiongwei Zhu;Diane Baus

  • Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity.

    Akinori Akaike;Yutaka Tamura;Takeharu Yokota;Shun Shimohama

  • Apoptosis in Alzheimer's disease--an update.

    Shun Shimohama

  • ESTRADIOL PROTECTS MESENCEPHALIC DOPAMINERGIC NEURONS FROM OXIDATIVE STRESS-INDUCED NEURONAL DEATH

    Hideyuki Sawada;Masakazu Ibi;Takeshi Kihara;Makoto Urushitani

  • Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation

    Shin Hisahara;Susumu Chiba;Hiroyuki Matsumoto;Masaya Tanno

  • Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease

    Yoshihisa Kitamura;Shun Shimohama;Wataru Kamoshima;Takashi Ota

  • Phosphatidylinositol 3‐kinase mediates neuroprotection by estrogen in cultured cortical neurons

    Kazuhiro Honda;Hideyuki Sawada;Takeshi Kihara;Makoto Urushitani

  • Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.

    Masatoshi Inden;Yoshihisa Kitamura;Hiroki Takeuchi;Takashi Yanagida

  • Trophic effect of β-amyloid precursor protein on cerebral cortical neurons in culture

    Wataru Araki;Nobuya Kitaguchi;Yasuo Tokushima;Kazuhiro Ishii

  • Protective effects of 1α,25-(OH)2D3 against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture

    M Ibi;H Sawada;M Nakanishi;T Kume

Frequent Co-Authors

Jun Kimura
Jun Kimura University of Iowa
Akinori Akaike
Akinori Akaike Kyoto University
Takeshi Kihara
Takeshi Kihara Kyoto University
Takashi Taniguchi
Takashi Taniguchi National Institute for Materials Science
Ryosuke Takahashi
Ryosuke Takahashi Kyoto University
George Perry
George Perry The University of Texas at San Antonio
Masakuni Kameyama
Masakuni Kameyama Kyoto University
Mark A. Smith
Mark A. Smith Case Western Reserve University
Hiroshi Shibasaki
Hiroshi Shibasaki Kyoto University
Shuji Kaneko
Shuji Kaneko Kyoto University

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