D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 88 Citations 25,891 465 World Ranking 8459 National Ranking 234

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Enzyme

Shun Shimohama focuses on Internal medicine, Endocrinology, Neuroprotection, Cell biology and Oxidative stress. His Internal medicine research focuses on Disease in particular. His Endocrinology research includes themes of Neurotrophic factors, Downregulation and upregulation, Activator and Cytosol.

His Neuroprotection study integrates concerns from other disciplines, such as Glutamate receptor, Neurotoxicity, Dopaminergic and Nicotine. In his research, Molecular biology is intimately related to Biochemistry, which falls under the overarching field of Cell biology. His Oxidative stress study incorporates themes from Alzheimer's disease, Reactive oxygen species, Programmed cell death and Degenerative disease.

His most cited work include:

  • Oxidative damage is the earliest event in Alzheimer disease. (1495 citations)
  • Mitochondrial abnormalities in Alzheimer's disease. (1051 citations)
  • α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity (390 citations)

What are the main themes of his work throughout his whole career to date?

Internal medicine, Cell biology, Endocrinology, Neuroscience and Biochemistry are his primary areas of study. His biological study spans a wide range of topics, including Downregulation and upregulation and Human brain. The study incorporates disciplines such as Glutamate receptor, Presenilin and Microglia in addition to Cell biology.

The Endocrinology study which covers Neuroprotection that intersects with Nicotinic agonist and Nicotine. His work deals with themes such as Oxidative stress, Signal transduction, Molecular biology and Degenerative disease, which intersect with Alzheimer's disease. Shun Shimohama has included themes like Neurotoxicity and Parkinson's disease in his Dopaminergic study.

He most often published in these fields:

  • Internal medicine (24.25%)
  • Cell biology (21.46%)
  • Endocrinology (20.60%)

What were the highlights of his more recent work (between 2014-2021)?

  • Pathology (12.23%)
  • Internal medicine (24.25%)
  • Cell biology (21.46%)

In recent papers he was focusing on the following fields of study:

Shun Shimohama mainly focuses on Pathology, Internal medicine, Cell biology, Microglia and Neuroscience. Sarcoma is closely connected to Mutation in his research, which is encompassed under the umbrella topic of Pathology. The Internal medicine study combines topics in areas such as Gastroenterology, Multiple sclerosis, Endocrinology and Cardiology.

Shun Shimohama works in the field of Cell biology, focusing on Mitochondrion in particular. His Neuroscience research is multidisciplinary, incorporating perspectives in Genetically modified mouse, Nicotinic agonist and Acetylcholine receptor. As part of one scientific family, he deals mainly with the area of Neuroprotection, narrowing it down to issues related to the Signal transduction, and often Nicotinic acetylcholine receptor.

Between 2014 and 2021, his most popular works were:

  • Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging. (37 citations)
  • Idiopathic normal pressure hydrocephalus has a different cerebrospinal fluid biomarker profile from Alzheimer's disease. (31 citations)
  • High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation (29 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Enzyme

His primary areas of investigation include Pathology, Microglia, Internal medicine, Neuroscience and Genetically modified mouse. His Pathology research focuses on subjects like Transplantation, which are linked to Substantia nigra and Dopaminergic. His Microglia research integrates issues from Phagocytosis, Cell biology, Downregulation and upregulation, Internalization and Hippocampus.

His studies deal with areas such as Gastroenterology, Multiple sclerosis, Endocrinology and Very Long-Chain Acyl-CoA Dehydrogenase Deficiency as well as Internal medicine. His study of Neuroprotection is a part of Neuroscience. His studies in Neuroprotection integrate themes in fields like Signal transduction and Nicotinic acetylcholine receptor.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Oxidative damage is the earliest event in Alzheimer disease.

Akihiko Nunomura;George Perry;Gjumrakch Aliev;Keisuke Hirai;Keisuke Hirai.
Journal of Neuropathology and Experimental Neurology (2001)

2170 Citations

Mitochondrial abnormalities in Alzheimer's disease.

Keisuke Hirai;Gjumrakch Aliev;Akihiko Nunomura;Akihiko Nunomura;Hisashi Fujioka.
The Journal of Neuroscience (2001)

1530 Citations

Activation and Involvement of p38 Mitogen-activated Protein Kinase in Glutamate-induced Apoptosis in Rat Cerebellar Granule Cells *

Hiroshi Kawasaki;Takaya Morooka;Shun Shimohama;Jun Kimura.
Journal of Biological Chemistry (1997)

533 Citations

α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity

Takeshi Kihara;Shun Shimohama;Hideyuki Sawada;Kazuhiro Honda.
Journal of Biological Chemistry (2001)

502 Citations

Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity

T. Kihara;S. Shimohama;H. Sawada;J. Kimura.
Annals of Neurology (1997)

422 Citations

Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study

James F Howard;Kimiaki Utsugisawa;Michael Benatar;Hiroyuki Murai.
Lancet Neurology (2017)

417 Citations

Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins

Jun Ichi Kakimura;Yoshihisa Kitamura;Kazuyuki Takata;Masaaki Umeki.
The FASEB Journal (2002)

377 Citations

Activation of NADPH oxidase in Alzheimer's disease brains.

Shun Shimohama;Hiroko Tanino;Naoko Kawakami;Naoki Okamura.
Biochemical and Biophysical Research Communications (2000)

371 Citations

Changes in nicotinic and muscarinic cholinergic receptors in Alzheimer-type dementia.

Shun Shimohama;Takashi Taniguchi;Motohatsu Fujiwara;Masakuni Kameyama.
Journal of Neurochemistry (1986)

361 Citations

Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity.

Akinori Akaike;Yutaka Tamura;Takeharu Yokota;Shun Shimohama.
Brain Research (1994)

344 Citations

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