Shun Shimohama focuses on Internal medicine, Endocrinology, Neuroprotection, Cell biology and Oxidative stress. His Internal medicine research focuses on Disease in particular. His Endocrinology research includes themes of Neurotrophic factors, Downregulation and upregulation, Activator and Cytosol.
His Neuroprotection study integrates concerns from other disciplines, such as Glutamate receptor, Neurotoxicity, Dopaminergic and Nicotine. In his research, Molecular biology is intimately related to Biochemistry, which falls under the overarching field of Cell biology. His Oxidative stress study incorporates themes from Alzheimer's disease, Reactive oxygen species, Programmed cell death and Degenerative disease.
Internal medicine, Cell biology, Endocrinology, Neuroscience and Biochemistry are his primary areas of study. His biological study spans a wide range of topics, including Downregulation and upregulation and Human brain. The study incorporates disciplines such as Glutamate receptor, Presenilin and Microglia in addition to Cell biology.
The Endocrinology study which covers Neuroprotection that intersects with Nicotinic agonist and Nicotine. His work deals with themes such as Oxidative stress, Signal transduction, Molecular biology and Degenerative disease, which intersect with Alzheimer's disease. Shun Shimohama has included themes like Neurotoxicity and Parkinson's disease in his Dopaminergic study.
Shun Shimohama mainly focuses on Pathology, Internal medicine, Cell biology, Microglia and Neuroscience. Sarcoma is closely connected to Mutation in his research, which is encompassed under the umbrella topic of Pathology. The Internal medicine study combines topics in areas such as Gastroenterology, Multiple sclerosis, Endocrinology and Cardiology.
Shun Shimohama works in the field of Cell biology, focusing on Mitochondrion in particular. His Neuroscience research is multidisciplinary, incorporating perspectives in Genetically modified mouse, Nicotinic agonist and Acetylcholine receptor. As part of one scientific family, he deals mainly with the area of Neuroprotection, narrowing it down to issues related to the Signal transduction, and often Nicotinic acetylcholine receptor.
His primary areas of investigation include Pathology, Microglia, Internal medicine, Neuroscience and Genetically modified mouse. His Pathology research focuses on subjects like Transplantation, which are linked to Substantia nigra and Dopaminergic. His Microglia research integrates issues from Phagocytosis, Cell biology, Downregulation and upregulation, Internalization and Hippocampus.
His studies deal with areas such as Gastroenterology, Multiple sclerosis, Endocrinology and Very Long-Chain Acyl-CoA Dehydrogenase Deficiency as well as Internal medicine. His study of Neuroprotection is a part of Neuroscience. His studies in Neuroprotection integrate themes in fields like Signal transduction and Nicotinic acetylcholine receptor.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Oxidative damage is the earliest event in Alzheimer disease.
Akihiko Nunomura;George Perry;Gjumrakch Aliev;Keisuke Hirai;Keisuke Hirai.
Journal of Neuropathology and Experimental Neurology (2001)
Mitochondrial abnormalities in Alzheimer's disease.
Keisuke Hirai;Gjumrakch Aliev;Akihiko Nunomura;Akihiko Nunomura;Hisashi Fujioka.
The Journal of Neuroscience (2001)
Activation and Involvement of p38 Mitogen-activated Protein Kinase in Glutamate-induced Apoptosis in Rat Cerebellar Granule Cells *
Hiroshi Kawasaki;Takaya Morooka;Shun Shimohama;Jun Kimura.
Journal of Biological Chemistry (1997)
α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity
Takeshi Kihara;Shun Shimohama;Hideyuki Sawada;Kazuhiro Honda.
Journal of Biological Chemistry (2001)
Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity
T. Kihara;S. Shimohama;H. Sawada;J. Kimura.
Annals of Neurology (1997)
Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study
James F Howard;Kimiaki Utsugisawa;Michael Benatar;Hiroyuki Murai.
Lancet Neurology (2017)
Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins
Jun Ichi Kakimura;Yoshihisa Kitamura;Kazuyuki Takata;Masaaki Umeki.
The FASEB Journal (2002)
Activation of NADPH oxidase in Alzheimer's disease brains.
Shun Shimohama;Hiroko Tanino;Naoko Kawakami;Naoki Okamura.
Biochemical and Biophysical Research Communications (2000)
Changes in nicotinic and muscarinic cholinergic receptors in Alzheimer-type dementia.
Shun Shimohama;Takashi Taniguchi;Motohatsu Fujiwara;Masakuni Kameyama.
Journal of Neurochemistry (1986)
Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity.
Akinori Akaike;Yutaka Tamura;Takeharu Yokota;Shun Shimohama.
Brain Research (1994)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:
University of Iowa
Kyoto University
National Institute for Materials Science
Kyoto University
The University of Texas at San Antonio
Case Western Reserve University
Kyoto University
Kyoto University
Case Western Reserve University
Kobe University
University of Paris-Saclay
National University of Ireland, Galway
Peking University
Forschungszentrum Jülich
Predicine
University of Tokyo
Wildlife Conservation Society
The Ohio State University
Mayo Clinic
University of Illinois at Chicago
University of North Carolina at Chapel Hill
University of Colorado Anschutz Medical Campus
Desert Research Institute
Italian Institute of Technology
Université Paris Cité
University of Michigan–Ann Arbor