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Akinori Akaike

Akinori Akaike

D-Index & Metrics

Medicine

D-Index
85
Citations
21477
World Ranking
14780
National Ranking
451

Overview

Akinori Akaike is affiliated with Kyoto University in Japan. Their research work spans fields including Medicine and Biochemistry, Genetics, and Molecular Biology with a focus on several key subfields such as Molecular Biology, Neurology, Physiology, Public Health, Environmental and Occupational Health, and Virology.

The scientist has contributed research on diverse topics, including:

  • Genomics, phytochemicals, and oxidative stress
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Parkinson's Disease Mechanisms and Treatments
  • Mosquito-borne diseases and control
  • Lipid Membrane Structure and Behavior
  • Rabies epidemiology and control
  • Heme Oxygenase-1 and Carbon Monoxide

Akaike's recent publications cover a range of specialized subjects and have appeared in several scientific venues. Notable papers include:

  • "Multiplex Neural Circuit Tracing With G-Deleted Rabies Viral Vectors," 2020, Frontiers in Neural Circuits
  • "Protective effects of Nrf2-ARE activator on dopaminergic neuronal loss in Parkinson disease model mice: Possible involvement of heme oxygenase-1," 2020, Neuroscience Letters
  • "Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis," 2021, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  • "In vivo brain ischemia-reperfusion model induced by hypoxia-reoxygenation using zebrafish larvae," 2021, Brain Research Bulletin
  • "Isolation and Purification of Harpagogenin as an Nrf2-ARE Activator from the Tubers of Chinese Artichoke (Stachys sieboldii)," 2023, Biological and Pharmaceutical Bulletin

The scientist has published multiple times in venues such as the Proceedings for Annual Meeting of The Japanese Pharmacological Society, Frontiers in Neural Circuits, Neuroscience Letters, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, and Brain Research Bulletin.

Frequent collaborators include:

  • Yasuhiko Izumi
  • Toshiaki Kume
  • Yuki Takada-Takatori
  • Yutaka Kōyama
  • Katsuharu Tsuchida

The research contributions of Akinori Akaike reflect interests across molecular and neurological mechanisms of diseases, including Parkinson's disease and amyotrophic lateral sclerosis, with additional attention to neuroprotective pathways, viral vector techniques, and phytochemical activators related to oxidative stress. This scholarly profile highlights a multidisciplinary approach in both basic and applied biological sciences.

Best Publications

  • Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells

    Fumitaka Osakada;Hanako Ikeda;Michiko Mandai;Takafumi Wataya

  • α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity

    Takeshi Kihara;Shun Shimohama;Hideyuki Sawada;Kazuhiro Honda

  • Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity

    T. Kihara;S. Shimohama;H. Sawada;J. Kimura

  • Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?

    Atsushi Nishiyori;Masabumi Minami;Yoshikazu Ohtani;Shinya Takami

  • Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells

    Masaya Nakanishi;Tetsuhiro Niidome;Satoru Matsuda;Akinori Akaike

  • Wnt Signaling Promotes Regeneration in the Retina of Adult Mammals

    Fumitaka Osakada;Sotaro Ooto;Tadamichi Akagi;Michiko Mandai

  • Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity.

    Akinori Akaike;Yutaka Tamura;Takeharu Yokota;Shun Shimohama

  • ESTRADIOL PROTECTS MESENCEPHALIC DOPAMINERGIC NEURONS FROM OXIDATIVE STRESS-INDUCED NEURONAL DEATH

    Hideyuki Sawada;Masakazu Ibi;Takeshi Kihara;Makoto Urushitani

  • Phosphatidylinositol 3‐kinase mediates neuroprotection by estrogen in cultured cortical neurons

    Kazuhiro Honda;Hideyuki Sawada;Takeshi Kihara;Makoto Urushitani

  • Protective effects of 1α,25-(OH)2D3 against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture

    M Ibi;H Sawada;M Nakanishi;T Kume

  • Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features.

    Yoshiari Shimmyo;Takeshi Kihara;Akinori Akaike;Tetsuhiro Niidome

  • Nicotinic Acetylcholine Receptor-Mediated Neuroprotection by Donepezil Against Glutamate Neurotoxicity in Rat Cortical Neurons

    Yuki Takada;Atsushi Yonezawa;Toshiaki Kume;Hiroshi Katsuki

  • A critical role of TRPM2 in neuronal cell death by hydrogen peroxide

    Shuji Kaneko;Seiko Kawakami;Yuji Hara;Minoru Wakamori

  • Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults.

    Mitsugi Okawara;Hiroshi Katsuki;Emi Kurimoto;Haruki Shibata

  • Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via α7-neuronal receptors and neuronal CNS receptors

    Satoshi Kaneko;Takehiko Maeda;Toshiaki Kume;Hanae Kochiyama

  • Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β-amyloid toxicity

    T Kihara;S Shimohama;M Urushitani;H Sawada

  • Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade.

    Yuki Takada-Takatori;Toshiaki Kume;Mitsuhiro Sugimoto;Hiroshi Katsuki

  • Analgesia induced by microinjection of morphine into, and electrical stimulation of, the nucleus reticularis paragigantocellularis of rat medulla oblongata

    A. Akaike;T. Shibata;M. Satoh;H. Takagi

  • Mechanisms of Neuroprotective Effects of Nicotine and Acetylcholinesterase Inhibitors: Role of α4 and α7 Receptors in Neuroprotection

    Akinori Akaike;Yuki Takada-Takatori;Toshiaki Kume;Yasuhiko Izumi

  • Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons

    Hideyuki Sawada;Masakazu Ibi;Takeshi Kihara;Makoto Urushitani

Frequent Co-Authors

Shuji Kaneko
Shuji Kaneko Kyoto University
Shun Shimohama
Shun Shimohama Sapporo Medical University
Masashi Sasa
Masashi Sasa Hiroshima University
Takeshi Kihara
Takeshi Kihara Kyoto University
Jun Kimura
Jun Kimura University of Iowa
Hiroshi Takagi
Hiroshi Takagi Okinawa Institute of Science and Technology
Ryosuke Takahashi
Ryosuke Takahashi Kyoto University
Hiroshi Takagi
Hiroshi Takagi Nara Institute of Science and Technology
Yoshimi Misu
Yoshimi Misu Yokohama City University
Yoshio Goshima
Yoshio Goshima Yokohama City University

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