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Biology and Biochemistry

D-Index
87
Citations
26678
World Ranking
2836
National Ranking
179

Overview

Hideaki Hara is affiliated with Gifu Pharmaceutical University in Japan and has conducted extensive research across multiple fields within medicine and biochemistry. Their work focuses primarily on molecular biology, ophthalmology, and neurology, with notable contributions in physiology and cell biology as well.

Their research themes cover a range of biomedical topics, including retinal diseases and treatments, retinal development and disorders, glaucoma and retinal disorders, neuroinflammation and neurodegeneration mechanisms, intracerebral and subarachnoid hemorrhage research, neurogenetic and muscular disorders research, and antioxidant activity and oxidative stress.

Hideaki Hara has authored several scientific papers published in a variety of journals. Some recently published works include:

  • A triterpenoid Nrf2 activator, RS9, promotes LC3-associated phagocytosis of photoreceptor outer segments in a p62-independent manner (2020), published in Free Radical Biology and Medicine
  • Canagliflozin Inhibits Glioblastoma Growth and Proliferation by Activating AMPK (2022), published in Cellular and Molecular Neurobiology
  • Discovery of a CNS penetrant small molecule SMN2 splicing modulator with improved tolerability for spinal muscular atrophy (2020), published in Scientific Reports
  • Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma (2020), published in Marine Drugs
  • Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage (2021), published in Journal of Cerebral Blood Flow & Metabolism

Their frequent coauthors include Masamitsu Shimazawa, Shinsuke Nakamura, Wataru Otsu, Satoshi Inagaki, and Anri Nishinaka, with collaboration counts ranging from 14 to 89 publications together.

Hideaki Hara's publications appear often in the following journals and venues:

  • Journal of Pharmacological Sciences (13 publications)
  • Proceedings for Annual Meeting of The Japanese Pharmacological Society (12 publications)
  • BPB Reports (9 publications)
  • Experimental Eye Research (7 publications)
  • Scientific Reports (4 publications)

The scope of their research spans an extensive number of studies related to medicine (171 publications) and biochemistry, genetics, and molecular biology (99 publications), demonstrating a multidisciplinary approach to their scientific inquiry.

Best Publications

  • Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.

    Hideaki Hara;Robert M. Friedlander;Valeria Gagliardini;Cenk Ayata

  • Defects in regulation of apoptosis in caspase-2-deficient mice

    Louise Bergeron;Gloria I. Perez;Glen Macdonald;Lianfa Shi

  • Expression of a Dominant Negative Mutant of Interleukin-1β Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury

    Robert M. Friedlander;Valeria Gagliardini;Hideaki Hara;Klaus B. Fink

  • Reduced Brain Edema and Infarction Volume in Mice Lacking the Neuronal Isoform of Nitric Oxide Synthase After Transient MCA Occlusion

    Hideaki Hara;Paul L. Huang;Nariman Panahian;Mark C. Fishman

  • Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions.

    Shin-Jung Kang;Suyue Wang;Hideaki Hara;Erin P. Peterson

  • A molecular chaperone inducer protects neurons from ER stress

    T Kudo;S Kanemoto;S Kanemoto;H Hara;N Morimoto

  • The Experimental and Clinical Pharmacology of Propofol, an Anesthetic Agent with Neuroprotective Properties

    Yoshinori Kotani;Masamitsu Shimazawa;Shinichi Yoshimura;Toru Iwama

  • Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein

    Hideaki Hara;Klaus Fink;Matthias Endres;Robert M. Friedlander

  • Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

    K. Hyakkoku;J. Hamanaka;K. Tsuruma;M. Shimazawa

  • Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light

    Yoshiki Kuse;Kenjiro Ogawa;Kazuhiro Tsuruma;Masamitsu Shimazawa

  • Strain-Related Differences in Susceptibility to Transient Forebrain Ischemia in SV-129 and C57Black/6 Mice

    Masazumi Fujii;Hideaki Hara;Wei Meng;Jean Paul Vonsattel

  • Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions.

    Yoshimi Nakajima;Masamitsu Shimazawa;Satoshi Mishima;Hideaki Hara

  • Protective effect of α-tocopherol on ischemic neuronal damage in the gerbil hippocampus

    Hideaki Hara;Hiroyuki Kato;Kyuya Kogure

  • Neuroprotective effect of recombinant human granulocyte colony-stimulating factor in transient focal ischemia of mice.

    Miki Komine-Kobayashi;Ning Zhang;Meizi Liu;Ryota Tanaka

  • Mechanisms of Reduced Striatal NMDA Excitotoxicity in Type I Nitric Oxide Synthase Knock-Out Mice

    C Ayata;G Ayata;H Hara;R T Matthews

  • Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil and rat.

    Hideaki Hara;Hiroshi Onodera;Mikio Yoshidomi;Yuzuru Matsuda

  • BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer.

    Shinichi Kondo;Atsushi Saito;Shin Ichiro Hino;Tomohiko Murakami

  • Comparison of bee products based on assays of antioxidant capacities

    Yoshimi Nakajima;Kazuhiro Tsuruma;Masamitsu Shimazawa;Satoshi Mishima

  • Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone).

    Tomomi Masuda;Masamitsu Shimazawa;Hideaki Hara

  • Vitreous fluid levels of β-amyloid(1–42) and tau in patients with retinal diseases

    Shinji Yoneda;Hideaki Hara;Akira Hirata;Mikiko Fukushima

Frequent Co-Authors

Masamitsu Shimazawa
Masamitsu Shimazawa Gifu Pharmaceutical University
Kyuya Kogure
Kyuya Kogure Tohoku University
Makoto Araie
Makoto Araie University of Tokyo
Michael A. Moskowitz
Michael A. Moskowitz Harvard University
Kazunori Imaizumi
Kazunori Imaizumi Hiroshima University
Hirotaka Onoe
Hirotaka Onoe Kyoto University
Paul L. Huang
Paul L. Huang Harvard University
Junying Yuan
Junying Yuan Harvard University
Yasunori Okada
Yasunori Okada Juntendo University
Masatoshi Takeda
Masatoshi Takeda Izumi University

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