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Biology and Biochemistry

D-Index
73
Citations
15858
World Ranking
6055
National Ranking
387

Overview

Masamitsu Shimazawa is affiliated with Gifu Pharmaceutical University in Japan. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, focusing primarily on molecular biology, ophthalmology, neurology, physiology, and cell biology.

The scientist's work covers a range of topics including retinal diseases and treatments, retinal development and disorders, glaucoma and retinal disorders, neuroinflammation and neurodegeneration mechanisms, antioxidant activity and oxidative stress, intracerebral and subarachnoid hemorrhage research, and Alzheimer's disease research and treatments.

Shimazawa has published extensively in various scientific journals. Frequent publication venues include the Journal of Pharmacological Sciences, Proceedings for Annual Meeting of The Japanese Pharmacological Society, BPB Reports, Experimental Eye Research, and Biological and Pharmaceutical Bulletin.

Key recent publications include:

  • A triterpenoid Nrf2 activator, RS9, promotes LC3-associated phagocytosis of photoreceptor outer segments in a p62-independent manner (2020, Free Radical Biology and Medicine)
  • Canagliflozin Inhibits Glioblastoma Growth and Proliferation by Activating AMPK (2022, Cellular and Molecular Neurobiology)
  • Discovery of a CNS penetrant small molecule SMN2 splicing modulator with improved tolerability for spinal muscular atrophy (2020, Scientific Reports)
  • Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma (2020, Marine Drugs)
  • The Mitochondria-targeted Peptide, Bendavia, Attenuated Ischemia/Reperfusion-induced Stroke Damage (2020, Neuroscience)

Shimazawa frequently collaborates with other researchers. Notable coauthors include Hideaki Hara, Shinsuke Nakamura (with two separate records indicating extensive collaboration), Wataru Otsu, and Shohei Tsuji.

Best Publications

  • The Experimental and Clinical Pharmacology of Propofol, an Anesthetic Agent with Neuroprotective Properties

    Yoshinori Kotani;Masamitsu Shimazawa;Shinichi Yoshimura;Toru Iwama

  • Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

    K. Hyakkoku;J. Hamanaka;K. Tsuruma;M. Shimazawa

  • Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light

    Yoshiki Kuse;Kenjiro Ogawa;Kazuhiro Tsuruma;Masamitsu Shimazawa

  • Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions.

    Yoshimi Nakajima;Masamitsu Shimazawa;Satoshi Mishima;Hideaki Hara

  • Comparison of bee products based on assays of antioxidant capacities

    Yoshimi Nakajima;Kazuhiro Tsuruma;Masamitsu Shimazawa;Satoshi Mishima

  • Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone).

    Tomomi Masuda;Masamitsu Shimazawa;Hideaki Hara

  • Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity.

    Mika Yamauchi;Kazuhiro Tsuruma;Shunsuke Imai;Tomohiro Nakanishi

  • Involvement of ER stress in retinal cell death.

    Masamitsu Shimazawa;Yuta Inokuchi;Yasu shi Ito;Hiroshi Murata

  • Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye.

    Kohei Hironaka;Yuta Inokuchi;Yuichi Tozuka;Masamitsu Shimazawa

  • Neuroprotection by Brazilian Green Propolis against In vitro and In vivo Ischemic Neuronal Damage.

    Masamitsu Shimazawa;Satomi Chikamatsu;Nobutaka Morimoto;Satoshi Mishima

  • The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment.

    Yusuke Egashira;Yusuke Egashira;Yukiya Suzuki;Yukio Azuma;Toshinori Takagi

  • Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice

    Yasushi Ito;Mitsunori Yamada;Hirotaka Tanaka;Kazunari Aida

  • Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage

    Nobutaka Morimoto;Masamitsu Shimazawa;Tetsumori Yamashima;Hiroichi Nagai

  • Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons

    Kentaro Yamashita;Yoshinori Kotani;Yoshinori Kotani;Yoshimi Nakajima;Masamitsu Shimazawa

  • Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo.

    Yoshimi Nakajima;Yuta Inokuchi;Masamitsu Shimazawa;Kazumasa Otsubo

  • The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis

    Hirotaka Tanaka;Masamitsu Shimazawa;Masataka Kimura;Masafumi Takata

  • Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis.

    M Takata;H Tanaka;M Kimura;Y Nagahara

  • Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo.

    Yoshimi Nakajima;Yuta Inokuchi;Masahiro Nishi;Masamitsu Shimazawa

  • Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells

    Hiroshi Izuta;Masamitsu Shimazawa;Kazuhiro Tsuruma;Yoko Araki

  • Docosahexaenoic acid (DHA) has neuroprotective effects against oxidative stress in retinal ganglion cells.

    Masamitsu Shimazawa;Yoshimi Nakajima;Yukihiko Mashima;Hideaki Hara

Frequent Co-Authors

Hideaki Hara
Hideaki Hara Gifu Pharmaceutical University
Makoto Araie
Makoto Araie University of Tokyo
Kazunori Imaizumi
Kazunori Imaizumi Hiroshima University
Kohji Fukunaga
Kohji Fukunaga Tohoku University
Yasunori Okada
Yasunori Okada Juntendo University
Hiroichi Nagai
Hiroichi Nagai Gifu Pharmaceutical University
Naoki Inagaki
Naoki Inagaki Gifu Pharmaceutical University
Munekazu Iinuma
Munekazu Iinuma Gifu Pharmaceutical University
Toshio Tanaka
Toshio Tanaka Mie University
Hirotaka Onoe
Hirotaka Onoe Kyoto University

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