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Biology and Biochemistry

D-Index
65
Citations
12767
World Ranking
9317
National Ranking
4114

Overview

Sylvia B. Smith is affiliated with Augusta University in the United States. Their research focuses on diverse aspects within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. They have contributed extensively to Molecular Biology, Ophthalmology, Cellular and Molecular Neuroscience, Biological Psychiatry, and Materials Chemistry.

Their work addresses important topics including Pharmacological Receptor Mechanisms and Effects, Receptor Mechanisms and Signaling, Retinal Diseases and Treatments, Retinal Development and Disorders, Tryptophan and Brain Disorders, Nicotinic Acetylcholine Receptors Study, and Glaucoma and Retinal Disorders.

Smith has published research in several scientific venues, with the most frequent being:

  • Investigative Ophthalmology & Visual Science
  • Experimental Eye Research
  • International Journal of Molecular Sciences
  • American Journal Of Pathology
  • The Cambridge Structural Database

Frequent coauthors contribute significantly to their research collaborations. Notable collaborators include:

  • Haiyan Xiao
  • Jing Wang
  • Shannon R. Barwick
  • Kathryn Bollinger
  • Brendan Marshall

Their recent scientific papers exemplify the scope and focus of their research. These include:

  • The Short Variant of Optic Atrophy 1 (OPA1) Improves Cell Survival Under Oxidative Stress, 2020, Journal of Biological Chemistry
  • Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice, 2020, Journal of Clinical Medicine
  • Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa, 2020, Investigative Ophthalmology & Visual Science
  • Comparison of Sigma 1 Receptor Ligands SA4503 and PRE084 to (+)-Pentazocine in the rd10 Mouse Model of RP, 2020, Investigative Ophthalmology & Visual Science
  • Identification of Estrogen Signaling in a Prioritization Study of Intraocular Pressure-Associated Genes, 2021, International Journal of Molecular Sciences

Best Publications

  • The cystine/glutamate antiporter system xc- in health and disease: From molecular mechanisms to novel therapeutic opportunities

    Jan Lewerenz;Sandra J. Hewett;Ying Huang;Maria Lambros

  • GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon

    Muthusamy Thangaraju;Gail A. Cresci;Kebin Liu;Sudha Ananth

  • Death of retinal neurons in streptozotocin-induced diabetic mice.

    Pamela M. Martin;Penny Roon;Tracy K. Van Ells;Vadivel Ganapathy

  • Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations.

    Michel Cayouette;Sylvia B. Smith;S.Patricia Becerra;Claude Gravel

  • A role for macroautophagy in protection against 4-hydroxytamoxifen–induced cell death and the development of antiestrogen resistance

    Julia S. Samaddar;Virgil T. Gaddy;Jennifer Duplantier;Sudharsan Periyasamy Thandavan

  • SLC19: the folate/thiamine transporter family

    Vadivel Ganapathy;Sylvia B. Smith;Puttur D. Prasad

  • Expression and Differential Polarization of the Reduced-folate Transporter-1 and the Folate Receptor α in Mammalian Retinal Pigment Epithelium *

    Christy D. Chancy;Ramesh Kekuda;Wei Huang;Puttur D Prasad

  • Apoptotic cell death in the mouse retinal ganglion cell layer is induced in vivo by the excitatory amino acid homocysteine.

    Pamela Moore;Amira El-sherbeny;Penny Roon;Patricia V Schoenlein

  • Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury

    Jianping Peng;Jianping Peng;Xiaoning Li;Xiaoning Li;Dongshan Zhang;Dongshan Zhang;Jian Kang Chen

  • Transport of Amino Acid-Based Prodrugs by the Na+- and Cl--Coupled Amino Acid Transporter ATB0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery

    Takahiro Hatanaka;Masayuki Haramura;You Jun Fei;Seiji Miyauchi

  • Expression of slc5a8 in Kidney and Its Role in Na+-coupled Transport of Lactate

    Elangovan Gopal;You Jun Fei;Mitsuru Sugawara;Seiji Miyauchi

  • Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain

    Katsuhisa Inoue;Lina Zhuang;Dennis M. Maddox;Sylvia B. Smith

  • Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity

    Man Jiang;Qingqing Wei;Navjotsin Pabla;Guie Dong

  • SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases.

    Muthusamy Thangaraju;Elangovan Gopal;Pamela M. Martin;Sudha Ananth

  • Identity of SMCT1 (SLC5A8) as a neuron‐specific Na+‐coupled transporter for active uptake of l‐lactate and ketone bodies in the brain

    Pamela M. Martin;Elangovan Gopal;Sudha Ananth;Lina Zhuang

  • Structure, Function, and Regulation of Human Cystine/Glutamate Transporter in Retinal Pigment Epithelial Cells

    Christy C. Bridges;Ramesh Kekuda;Haiping Wang;Puttur D. Prasad

  • The Short Variant of the Mitochondrial Dynamin OPA1 Maintains Mitochondrial Energetics and Cristae Structure

    Hakjoo Lee;Sylvia B. Smith;Yisang Yoon

  • The rhodopsin cycle is preserved in IRBP "knockout" mice despite abnormalities in retinal structure and function.

    Harris Ripps;Neal S. Peachey;Xiaoping Xu;Susan E. Nozell

  • Transport of D-serine via the amino acid transporter ATB0,+ expressed in the colon

    Takahiro Hatanaka;Wei Huang;Takeo Nakanishi;Christy C. Bridges

  • In Vivo Protection against Retinal Neurodegeneration by Sigma Receptor 1 Ligand (+)-Pentazocine

    Sylvia B. Smith;Jennifer Duplantier;Ying Dun;Barbara Mysona

Frequent Co-Authors

Vadivel Ganapathy
Vadivel Ganapathy Texas Tech University Health Sciences Center
Puttur D. Prasad
Puttur D. Prasad Augusta University
Muthusamy Thangaraju
Muthusamy Thangaraju Augusta University
Ruth B. Caldwell
Ruth B. Caldwell Augusta University
Eric P. Zorrilla
Eric P. Zorrilla Scripps Research Institute
Kebin Liu
Kebin Liu Augusta University
Zheng Dong
Zheng Dong Augusta University
Rima Rozen
Rima Rozen McGill University
Neal S. Peachey
Neal S. Peachey Cleveland Clinic
Raju Kucherlapati
Raju Kucherlapati Harvard University

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