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Biology and Biochemistry

D-Index
54
Citations
11551
World Ranking
15548
National Ranking
6485

Overview

Joshua L. Dunaief is affiliated with the University of Pennsylvania in the United States and has contributed extensively to research in medicine, with a strong focus on ophthalmology and molecular biology. Their scholarly work explores various aspects of retinal diseases, retinal development, and related disorders, with a particular interest in iron metabolism and glaucoma.

The scientist's main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

They have specialized in several subfields such as:

  • Ophthalmology
  • Molecular Biology
  • Neurology
  • Hematology
  • Nutrition and Dietetics

Their research often covers key topics including:

  • Retinal Diseases and Treatments
  • Retinal Development and Disorders
  • Glaucoma and retinal disorders
  • Iron Metabolism and Disorders
  • Trace Elements in Health
  • Retinoids in leukemia and cellular processes
  • Retinal Imaging and Analysis

Joshua L. Dunaief has published multiple papers in prominent venues, contributing to scientific understanding in these areas. Recent papers include:

  • GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension (2020, Cell Reports)
  • Ferrous but not ferric iron sulfate kills photoreceptors and induces photoreceptor-dependent RPE autofluorescence (2020, Redox Biology)
  • Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions (2020, Progress in Retinal and Eye Research)
  • Glucagon-like peptide 1 receptor agonist use is associated with reduced risk for glaucoma (2021, British Journal of Ophthalmology)
  • Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein (2022, Cell Reports)

Frequent publication venues for their work include:

  • Experimental Eye Research
  • Cell Reports
  • Redox Biology
  • Aging Cell
  • bioRxiv (Cold Spring Harbor Laboratory)

Joshua L. Dunaief has collaborated regularly with several co-authors, including:

  • Jacob Sterling
  • Ying Song
  • Brent A. Bell
  • Qi N. Cui
  • Samyuktha Guttha

Best Publications

  • The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

    Joshua L. Dunaief;Bruce E. Strober;Sushovan Guha;Paul A. Khavari

  • DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

    Hiroki Kaneko;Sami Dridi;Valeria Tarallo;Bradley D. Gelfand

  • DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

    Valeria Tarallo;Yoshio Hirano;Bradley D. Gelfand;Sami Dridi

  • The Role of Apoptosis in Age-Related Macular Degeneration

    Joshua L. Dunaief;Tzvete Dentchev;Gui Shuang Ying;Ann H. Milam

  • mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice

    Chen Zhao;Douglas Yasumura;Xiyan Li;Michael Matthes

  • Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas.

    Tzvete Dentchev;Ann H Milam;Virginia M-Y Lee;John Q Trojanowski

  • Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins.

    B E Strober;J L Dunaief;Guha;S P Goff

  • Mitochondria‐derived Reactive Oxygen Species Mediate Blue Light‐induced Death of Retinal Pigment Epithelial Cells¶

    Ayala King;Eyal Gottlieb;David G. Brooks;Michael P. Murphy

  • Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration.

    Paul Hahn;Ying Qian;Tzvete Dentchev;Lin Chen

  • Iron homeostasis and toxicity in retinal degeneration

    Xining He;Paul Hahn;Jared Iacovelli;Robert Wong

  • Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane.

    Paul Hahn;Ann H. Milam;Joshua L. Dunaief

  • Oxidative stress in diseases of the human cornea

    Akiva Shoham;Majda Hadziahmetovic;Joshua L. Dunaief;Marc B. Mydlarski

  • LIGHT DAMAGE INDUCED CHANGES IN MOUSE RETINAL GENE EXPRESSION

    Lin Chen;Wayne Wu;Tzvete Dentchev;Yong Zeng

  • Iron Induced Oxidative Damage As a Potential Factor in Age-Related Macular Degeneration: The Cogan Lecture

    Joshua L. Dunaief

  • Foveolar Choroidal Circulation and Choroidal Neovascularization in Age-Related Macular Degeneration

    Tatyana I. Metelitsina;Juan E. Grunwald;Joan C. DuPont;Gui-Shuang Ying

  • Receptor for advanced glycation end products and age-related macular degeneration.

    Kimberly A. Howes;Yang Liu;Joshua L. Dunaief;Ann Milam

  • Macular degeneration in a patient with aceruloplasminemia, a disease associated with retinal iron overload.

    Joshua L. Dunaief;Chimene Richa;Edward P. Franks;Robert L. Schultze

  • Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16.

    Tiarnan D. Keenan;Elvira Agrón;Amitha Domalpally;Traci E. Clemons

  • DNA Methylation Is Associated with Altered Gene Expression in AMD

    Allan Hunter;Paul A. Spechler;Alyssa Cwanger;Ying Song

  • Amyloid-β is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas11Edited by Hans E. Grossniklaus, MD

    T Dentchev;A.H Milam;V.M.Y Lee;J.Q Trojanowski

Frequent Co-Authors

Jean Bennett
Jean Bennett University of Pennsylvania
Donald J. Zack
Donald J. Zack Johns Hopkins University School of Medicine
Chris D. Vulpe
Chris D. Vulpe University of Florida
Gregory J. Anderson
Gregory J. Anderson QIMR Berghofer Medical Research Institute
John L. Beard
John L. Beard Pennsylvania State University
Albert M. Maguire
Albert M. Maguire University of Pennsylvania
Tomas S. Aleman
Tomas S. Aleman University of Pennsylvania
Maureen G. Maguire
Maureen G. Maguire University of Pennsylvania
David J. Irwin
David J. Irwin University of Pennsylvania
Eric A. Pierce
Eric A. Pierce Massachusetts Eye and Ear Infirmary

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