World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
98
Citations
33572
World Ranking
1671
National Ranking
932

Overview

Douglas R. Spitz is affiliated with the University of Iowa in the United States. Their research primarily spans the fields of Medicine as well as Biochemistry, Genetics, and Molecular Biology. Within these main fields, the scientist has a significant focus on Molecular Biology, Nutrition and Dietetics, Oncology, Radiology, Nuclear Medicine and Imaging, and Pulmonary and Respiratory Medicine.

Their work addresses several main topics, including Vitamin C and Antioxidants Research, Effects of Radiation Exposure, Cancer, Hypoxia, and Metabolism, Radiation Therapy and Dosimetry, Folate and B Vitamins Research, Lanthanide and Transition Metal Complexes, and Nanoparticles: synthesis and applications.

Douglas R. Spitz has published numerous papers, with recent notable titles featured in well-known journals. These include:

  • Lymph protects metastasizing melanoma cells from ferroptosis, 2020, Nature
  • Radioresistance in Glioblastoma and the Development of Radiosensitizers, 2020, Cancers
  • The mechanism of cell death induced by silver nanoparticles is distinct from silver cations, 2021, Particle and Fibre Toxicology
  • Understanding High-Dose, Ultra-High Dose Rate, and Spatially Fractionated Radiation Therapy, 2020, International Journal of Radiation Oncology*Biology*Physics
  • Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes, 2020, Cell Metabolism

Frequent co-authors collaborating with Douglas R. Spitz include:

  • Bryan G. Allen
  • Kranti A. Mapuskar
  • Michael S. Petronek
  • Garry R. Buettner
  • Melissa A. Fath

The scientist has contributed extensively to several publication venues, such as:

  • International Journal of Radiation Oncology*Biology*Physics
  • Cancer Research
  • Redox Biology
  • Free Radical Biology and Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation

    Jeffrey R. Erickson;Mei ling A. Joiner;Xiaoqun Guan;William Kutschke

  • Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

    Randa Tao;Mitchell C. Coleman;J. Daniel Pennington;Ozkan Ozden

  • SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

    Hyun Seok Kim;Krish Patel;Kristi Muldoon-Jacobs;Kheem S. Bisht

  • An assay for superoxide dismutase activity in mammalian tissue homogenates.

    Douglas R. Spitz;Larry W. Oberley

  • Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology.

    Douglas R. Spitz;Edouard I. Azzam;Jian Jian Li;David Gius

  • Lymph protects metastasizing melanoma cells from ferroptosis

    Jessalyn M. Ubellacker;Alpaslan Tasdogan;Vijayashree Ramesh;Bo Shen

  • HSP27 Phosphorylation-mediated Resistance against Actin Fragmentation and Cell Death Induced by Oxidative Stress

    Jacques Huot;François Houle;Douglas R. Spitz;Jacques Landry

  • [61] Assay of superoxide dismutase activity in tumor tissue

    Larry W. Oberley;Douglas R. Spitz

  • Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation.

    Nùkhet Aykin-Burns;Iman M. Ahmad;Yueming Zhu;Larry W. Oberley

  • O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

    Joshua D. Schoenfeld;Zita A. Sibenaller;Kranti A. Mapuskar;Brett A. Wagner

  • Superoxide Mediates the Actions of Angiotensin II in the Central Nervous System

    Matthew C. Zimmerman;Eric Lazartigues;Julie A. Lang;Puspha Sinnayah

  • Oxidative Metabolism Modulates Signal Transduction and Micronucleus Formation in Bystander Cells from α-Particle-irradiated Normal Human Fibroblast Cultures

    Edouard I. Azzam;Sonia M. de Toledo;Sonia M. de Toledo;Douglas R. Spitz;John B. Little

  • Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil.

    Rathnagiri Polavarapu;Douglas R. Spitz;Julia E. Sim;Mark H. Follansbee

  • Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism?

    Douglas R. Spitz;Julia E. Sim;Lisa A. Ridnour;Sandra S. Galoforo

  • Reactive oxygen species in normal and tumor stem cells.

    Daohong Zhou;Lijian Shao;Douglas R. Spitz

  • Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism.

    Bryan G. Allen;Sudershan K. Bhatia;Carryn M. Anderson;Julie M. Eichenberger-Gilmore

  • H2O2-induced O⨪2Production by a Non-phagocytic NAD(P)H Oxidase Causes Oxidant Injury

    Wei Gen Li;Francis J. Miller;Hannah J. Zhang;Douglas R. Spitz

  • DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway.

    Kang Ma;So Ey;Simons Al;Spitz Dr

  • Manganese Superoxide Dismutase-Mediated Gene Expression in Radiation-Induced Adaptive Responses

    Guozheng Guo;Yan Yan-Sanders;Beverly D. Lyn-Cook;Tieli Wang

  • α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II

    Lan-Feng Dong;Pauline Low;Jeffrey C. Dyason;Xiu-Fang Wang

Frequent Co-Authors

Garry R. Buettner
Garry R. Buettner University of Iowa
Frederick E. Domann
Frederick E. Domann University of Iowa
David Gius
David Gius Northwestern University
John M. Buatti
John M. Buatti University of Iowa
Larry W. Oberley
Larry W. Oberley University of Iowa
Mark E. Anderson
Mark E. Anderson Johns Hopkins University
Brian J. Smith
Brian J. Smith QIMR Berghofer Medical Research Institute
Peter J. Mohler
Peter J. Mohler The Ohio State University
Phyllis A. Dennery
Phyllis A. Dennery Brown University
Jian Jian Li
Jian Jian Li University of California, Davis

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Considering a future in Biology and Biochemistry opens up several rewarding pathways. For students with a passion for nutrition and healthcare, pursuing registered dietitian masters programs can lead to careers that directly impact patient wellbeing. These programs blend core science with hands-on learning.

If you are looking for a flexible introduction to the medical field, there are many online medical assistant programs that accept financial aid. These make it possible to start your healthcare journey with minimal upfront investment, while also building vital skills for clinics and hospitals.

Ready to advance further? A ma to lpn bridge program allows current medical assistants to become Licensed Practical Nurses through focused, online pathways—making career growth more accessible than ever.

For those who want to speed up their academic progress, consider the advantages of an accelerated biology degree. These programs are designed for motivated students eager to enter the workforce or graduate school sooner without sacrificing academic rigor.

Best Scientists Citing Douglas R. Spitz

Trending Scientists