David A. Boothman mainly investigates Molecular biology, Apoptosis, Cancer research, Cancer cell and DNA repair. His research integrates issues of Cell culture, Camptothecin, Intracellular, Cytotoxicity and Topoisomerase in his study of Molecular biology. His studies in Apoptosis integrate themes in fields like Calpain, NAD+ kinase and Cell biology.
His Cancer research research incorporates themes from Epithelial–mesenchymal transition, Transforming growth factor beta, Signal transduction, Gene silencing and Prostate cancer. His research in Cancer cell tackles topics such as Pharmacology which are related to areas like Pancreatic tumor, Chemotherapy, Pancreatic cancer and Catalase. His work carried out in the field of DNA repair brings together such families of science as Downregulation and upregulation, Gene expression, DNA damage and Homology.
The scientist’s investigation covers issues in Cancer research, Molecular biology, DNA repair, Programmed cell death and Cancer cell. The various areas that David A. Boothman examines in his Cancer research study include Cancer, DNA damage, Biochemistry, Immunology and NAD+ kinase. David A. Boothman combines subjects such as Cell culture, Transcription factor, Gene expression, Gene and Genome instability with his study of Molecular biology.
His DNA repair research focuses on Cell biology and how it relates to Ku70. Programmed cell death is a subfield of Apoptosis that he investigates. His studies deal with areas such as PARP1 and Catalase as well as Cancer cell.
His main research concerns Cancer research, DNA damage, Cancer cell, Cancer and NAD+ kinase. David A. Boothman has included themes like Cell, Reactive oxygen species, Biochemistry and Poly ADP ribose polymerase, PARP1 in his Cancer research study. His DNA damage research is multidisciplinary, incorporating elements of Mutation, Immunology, Programmed cell death and DNA repair.
His DNA repair study incorporates themes from Molecular biology, Genome instability, DNA replication and Cell biology. His study in Molecular biology is interdisciplinary in nature, drawing from both Multiple tumors, Transcription factor and Quinone oxidoreductase. In his study, KRAS is inextricably linked to Lung cancer, which falls within the broad field of Cancer.
His scientific interests lie mostly in Cancer research, DNA repair, DNA damage, Biochemistry and Poly ADP ribose polymerase. The Cancer research study combines topics in areas such as Ligand, Oncogene, Immunology, Wild type and Gene silencing. The various areas that David A. Boothman examines in his DNA repair study include Cell aging, Genome instability, Molecular biology, Cell biology and Transcription.
His work investigates the relationship between Molecular biology and topics such as Transcription factor that intersect with problems in Signal transduction, Protein kinase B, MAPK/ERK pathway and Kinase. In the field of Biochemistry, his study on NAD+ kinase overlaps with subjects such as Ovarian carcinoma. His work in the fields of PARP1 and Poly Polymerase Inhibitor overlaps with other areas such as Nicotinamide adenine dinucleotide phosphate and Glutaminase.
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Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems.
Norased Nasongkla;Erik Bey;Jimin Ren;Hua Ai.
Nano Letters (2006)
Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice
Shigehiro Doi;Yonglong Zou;Osamu Togao;Johanne V. Pastor.
Journal of Biological Chemistry (2011)
cRGD-functionalized polymer micelles for targeted doxorubicin delivery.
Norased Nasongkla;Xintao Shuai;Hua Ai;Brent D. Weinberg.
Angewandte Chemie (2004)
Synthesis and functional analyses of nuclear clusterin, a cell death protein
Konstantin S. Leskov;Dmitry Y. Klokov;Jing Li;Timothy J. Kinsella.
Journal of Biological Chemistry (2003)
Ku70 suppresses the apoptotic translocation of Bax to mitochondria
Motoshi Sawada;Weiyong Sun;Paulette Hayes;Konstantin Leskov.
Nature Cell Biology (2003)
NAD(P)H:Quinone Oxidoreductase Activity Is the Principal Determinant of β-Lapachone Cytotoxicity
John J. Pink;Sarah M. Planchon;Colleen Tagliarino;Marie E. Varnes.
Journal of Biological Chemistry (2000)
Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases.
Julio C. Morales;Long Shan Li;Farjana J. Fattah;Ying Dong.
Critical Reviews in Eukaryotic Gene Expression (2014)
Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer
B. Shannan;M. Seifert;K. Leskov;J. Willis.
Cell Death & Differentiation (2006)
Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death
Chin Rang Yang;Konstantin Leskov;Kelly Hosley-Eberlein;Tracy Criswell.
Proceedings of the National Academy of Sciences of the United States of America (2000)
An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by β-lapachone
Erik A. Bey;Melissa S. Bentle;Kathryn E. Reinicke;Ying Dong.
Proceedings of the National Academy of Sciences of the United States of America (2007)
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