World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
80
Citations
28772
World Ranking
1567
National Ranking
727

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Richard Fishel is affiliated with The Ohio State University in the United States and works primarily in the fields of biochemistry, genetics, and molecular biology, with additional contributions to medicine. Their research spans several interconnected subfields, including molecular biology, pathology and forensic medicine, infectious diseases, immunology, and genetics.

The main topics explored in their work focus on RNA and protein synthesis mechanisms, genetic factors in colorectal cancer, RNA research and splicing, DNA repair mechanisms, CRISPR and genetic engineering, RNA modifications and cancer, and SARS-CoV-2 detection and testing.

Richard Fishel's recent publications include the following:

  • Strategies for Targeting Retroviral Integration for Safer Gene Therapy: Advances and Challenges, 2021, Frontiers in Molecular Biosciences
  • MutS functions as a clamp loader by positioning MutL on the DNA during mismatch repair, 2022, Nature Communications
  • Linker domain function predicts pathogenic MLH1 missense variants, 2021, Proceedings of the National Academy of Sciences
  • REMBRANDT: A high-throughput barcoded sequencing approach for COVID-19 screening, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • REMBRANDT: A High-Throughput Barcoded Sequencing Approach for COVID-19 Screening, 2021, Research Square (Research Square)

These publications indicate an engagement with gene therapy, molecular mechanisms related to DNA repair and mismatch repair, and methods for high-throughput screening, including applications relevant to COVID-19.

Fishel frequently collaborates with other researchers. Notable coauthors include:

  • James London
  • Jiaquan Liu
  • Anne M. Gardner
  • Kristine E. Yoder
  • Wayne Miles

Their research has been published in a variety of venues, often in journals and preprint servers that focus on molecular biology and biochemistry. Common publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • Nature Communications
  • Journal of Biological Chemistry
  • Frontiers in Molecular Biosciences

Richard Fishel was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2017, reflecting a professional acknowledgment within the scientific community.

Best Publications

  • The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.

    Richard Fishel;Mary Kay Lescoe;M.R.S. Rao;Neal G. Copeland

  • Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability

    Asad Umar;C. Richard Boland;Jonathan P. Terdiman;Sapna Syngal

  • Diagnostic Microsatellite Instability: Definition and Correlation with Mismatch Repair Protein Expression

    Wolfgang Dietmaier;Sabine Wallinger;Tina Bocker;Frank Kullmann

  • hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

    Samir Acharya;Teresa Wilson;Scott Gradia;Michael F. Kane

  • Loss of DNA mismatch repair in acquired resistance to cisplatin.

    S Aebi;B Kurdi-Haidar;R Gordon;B Cenni

  • Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation.

    Ayman Saleh;Srinivasa M. Srinivasula;Samir Acharya;Richard Fishel

  • hMSH4-hMSH5 Recognizes Holliday Junctions and Forms a Meiosis-Specific Sliding Clamp that Embraces Homologous Chromosomes

    Timothy Snowden;Samir Acharya;Charles Butz;Mark Berardini

  • MSH2 deficient mice are viable and susceptible to lymphoid tumours.

    A.H. Reitmair;R. Schmits;A. Ewel;B. Bapat

  • hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA

    Scott Gradia;Deepa Subramanian;Teresa Wilson;Samir Acharya

  • Modulation of mismatch repair and genomic stability by miR-155

    Nicola Valeri;Pierluigi Gasparini;Muller Fabbri;Chiara Braconi

  • DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics

    Tsuyoshi Ikura;Satoshi Tashiro;Akemi Kakino;Hiroki Shima

  • The Human Mismatch Recognition Complex hMSH2-hMSH6 Functions as a Novel Molecular Switch

    Scott Gradia;Samir Acharya;Richard Fishel

  • MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)

    Nicola Valeri;Pierluigi Gasparini;Chiara Braconi;Alessio Paone

  • Identification of mismatch repair genes and their role in the development of cancer

    Richard Fishel;Richard D Kolodner

  • BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.

    Artur Slupianek;Christoph Schmutte;Gregory Tombline;Malgorzata Nieborowska-Skorska

  • MLH1 Promoter Methylation and Gene Silencing is the Primary Cause of Microsatellite Instability in Sporadic Endometrial Cancers

    Sally B. Simpkins;Tina Bocker;Elizabeth M. Swisher;David G. Mutch

  • The Coordinated Functions of the E. coli MutS and MutL Proteins in Mismatch Repair

    Samir Acharya;Patricia L. Foster;Peter Brooks;Richard Fishel

  • Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors.

    Yali Xie;Hanjing Yang;Cristina Cunanan;Kimberly Okamoto

  • Genetic recombination of bacterial plasmid DNA: effect of RecF pathway mutations on plasmid recombination in Escherichia coli.

    R Kolodner;R A Fishel;M Howard

  • Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7.

    Yoshiki Murakumo;Yukiko Ogura;Hideshi Ishii;Shin Ichiro Numata

Frequent Co-Authors

Carlo M. Croce
Carlo M. Croce The Ohio State University
Richard D. Kolodner
Richard D. Kolodner University of California, San Diego
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
C. Richard Boland
C. Richard Boland University of California, San Diego
David A. Boothman
David A. Boothman Indiana University
Jack D. Griffith
Jack D. Griffith University of North Carolina at Chapel Hill
Tomasz Skorski
Tomasz Skorski Temple University
Massimo Negrini
Massimo Negrini University of Ferrara
Walter J. Curran
Walter J. Curran Emory University

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