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Genetics

D-Index
57
Citations
11989
World Ranking
3415
National Ranking
1477

Overview

Eric Alani is a researcher affiliated with Cornell University in the United States. Their work primarily focuses on the field of Biochemistry, Genetics, and Molecular Biology, with significant contributions in Molecular Biology, Pathology and Forensic Medicine, Genetics, Cancer Research, and Plant Science.

Their research centers on several topics including DNA Repair Mechanisms, Genetic factors in colorectal cancer, RNA Research and Splicing, Fungal and yeast genetics research, CRISPR and Genetic Engineering, Genomics and Chromatin Dynamics, and Cancer Genomics and Diagnostics.

Eric Alani has a publication record that includes recent papers such as:

  • Coordinated and Independent Roles for MLH Subunits in DNA Repair (2021, Cells)
  • Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging (2021, Nature Communications)
  • Expanded roles for the MutL family of DNA mismatch repair proteins (2020, Yeast)
  • Exo1 protects DNA nicks from ligation to promote crossover formation during meiosis (2023, PLoS Biology)
  • Collaborations between chromatin and nuclear architecture to optimize DNA repair fidelity (2020, DNA Repair)

Their frequent co-authors include Gianno Pannafino, Lisette Payero, Haiyuan Yu, Christopher M. Furman, and Michael Gioia.

Eric Alani has published predominantly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Cells, Nature Communications, Yeast, and PLoS Biology.

Best Publications

  • A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains.

    Eric Alani;Liang Cao;Nancy Kleckner

  • A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae

    Liang Cao;Eric Alani;Nancy Kleckner

  • Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination

    Eric Alani;Ruth Padmore;Nancy Kleckner

  • Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae

    Leonard Guarente;Beth Lalonde;Paula Gifford;Eric Alani

  • MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast

    T. A. Prolla;Qishen Pang;E. Alani;R. D. Kolodner

  • Interaction Between Mismatch Repair and Genetic Recombination in Saccharomyces cerevisiae

    Eric Alani;Robert A. G. Reenan;Richard D. Kolodner

  • Dynamic Basis for One-Dimensional DNA Scanning by the Mismatch Repair Complex Msh2-Msh6

    Jason Gorman;Arindam Chowdhury;Jennifer A. Surtees;Jun Shimada

  • Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1

    Neal Sugawara;Tamara Goldfarb;Barbara Studamire;Eric Alani

  • Characterization of DNA-binding and strand-exchange stimulation properties of y-RPA, a yeast single-strand-DNA-binding protein.

    Eric Alani;Randy Thresher;Jack D. Griffith;Richard D. Kolodner

  • DNA bending and unbending by MutS govern mismatch recognition and specificity.

    Hong Wang;Yong Yang;Mark J. Schofield;Chunwei Du

  • The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs.

    E Alani

  • Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice.

    Jason Gorman;Aaron J Plys;Mari-Liis Visnapuu;Eric Alani

  • Single-molecule imaging reveals target-search mechanisms during DNA mismatch repair.

    Jason Gorman;Feng Wang;Sy Redding;Aaron J. Plys

  • Competing Crossover Pathways Act During Meiosis in Saccharomyces cerevisiae

    Juan Lucas Argueso;Jennifer Wanat;Zekeriyya Gemici;Eric Alani

  • Mismatch repair proteins: key regulators of genetic recombination

    J A Surtees;J L Argueso;E Alani

  • The yeast RAD50 gene encodes a predicted 153-kD protein containing a purine nucleotide-binding domain and two large heptad-repeat regions.

    E Alani;S Subbiah;N Kleckner

  • Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition.

    E Alani;T Sokolsky;B Studamire;J J Miret

  • Roles for mismatch repair factors in regulating genetic recombination.

    Elizabeth Evans;Eric Alani

  • The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions.

    E Alani;N W Chi;R Kolodner

  • A Mutation in the Putative MLH3 Endonuclease Domain Confers a Defect in Both Mismatch Repair and Meiosis in Saccharomyces cerevisiae

    Koodali Nishant;Aaron J. Plys;Eric Alani

Frequent Co-Authors

Eric C. Greene
Eric C. Greene Columbia University
Charles F. Aquadro
Charles F. Aquadro Cornell University
Richard D. Kolodner
Richard D. Kolodner University of California, San Diego
Nancy Kleckner
Nancy Kleckner Harvard University
Paula E. Cohen
Paula E. Cohen Cornell University
Stephen K. Gray
Stephen K. Gray Victoria University
James E. Haber
James E. Haber Brandeis University
Carlos Bustamante
Carlos Bustamante Stanford University
Akira Shinohara
Akira Shinohara Osaka University
Terry J. Hassold
Terry J. Hassold Washington State University

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